I am a nephrologist, transplant specialist and translational physician-scientist specializing in patient-oriented research. I examine the factors involved in the pathogenesis, course, and survival of patients with kidney failure and kidney transplantation, with studies ranging from genotypic variation and molecular consequences to biologic markers of disease. In particular, my work focuses on the cardiovascular and metabolic complications associated with kidney transplant and immunosuppression, investigating the interplay of phenotypic, genetic and biochemical abnormalities inherent to those scenarios. Using a pharmacogenomics approach, I conduct my research using BioVU, Vanderbilt’s DNA biobank, and the Synthetic Derivative, corresponding electronic medical record data. I direct an ongoing prospective observational study of patients with kidney transplant, which involves the ascertainment of phenotypic data and biospecimens at 3-4 month intervals on all such patients followed at Vanderbilt University, and provides a unique resource for the prospective pharmacogenomics assessment of these patients. Furthermore, I have successfully conducted and published a genetic association study of polymorphisms of tacrolimus dose requirement in kidney transplant using BioVU/Synthetic Derivative, and I am NIH funded to use these same resources to determine genetic variants associated with new onset diabetes after transplant.
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1161 21st Avenue South
Nashville, TN 37232-2372
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAdolescent Aged Age Factors Antibody Formation Biomarkers Calcineurin Inhibitors Cohort Studies Computational Biology Delayed Graft Function Dose-Response Relationship, Drug Electronic Health Records Enzyme Inhibitors Female Glomerular Filtration Rate Graft Survival Immunity Influenza, Human Influenza B virus Kidney Kidney Transplantation Male Middle Aged new onset diabetes after transplant Odds Ratio Orthomyxoviridae Pharmacogenetics pharmacogenetics Precision Medicine Prospective Studies Receptors, Steroid Renal Dialysis tacrolimus Tacrolimus Transplantation