Profile

The general focus of the Harris laboratory involves studies of regulation of renal epithelial cell growth and function during normal physiologic responses and after acute or chronic injury.  An area of continuing interest in the laboratory is regulation of renal epithelial cell function by eicosanoids. We are continuing intensive investigation of the regulation and physiologic and pathophysiologic roles of cyclooxygenase-2 and its metabolites in the kidney. We are also investigating signaling pathways in renal epithelial cells of P450-derived arachidonate metabolites, epoxyeicosatrienoic acids (EETs). We have also recently identified a novel monoglyceride derivative of the EETs, which signals through an identified family of membrane receptors and elicits biological responses, and our studies involve investigation of expression, regulation and physiologic responses of these compounds. We are also interested in understanding mechanisms of repair in response to acute renal epithelial injury. A third area of interest is the underlying mechanisms mediating progressive kidney disease, and especially diabetic nephropathy. We are currently investigating  the role of epidermal growth factor signaling in both recovery from acute kidney injury and as a mediator of progressive glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy. The overall goal of the studies in the laboratory is to identify new targets for intervention and therapy of kidney disease.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J (2017) J Clin Invest
    › Primary publication · 28414295 (PubMed)
  2. FSTL3 is increased in renal dysfunction. Kralisch S, Hoffmann A, Klöting N, Bachmann A, Kratzsch J, Stolzenburg JU, Dietel A, Beige J, Anders M, Bast I, Blüher M, Zhang MZ, Harris RC, Stumvoll M, Fasshauer M, Ebert T (2017) Nephrol Dial Transplant
    › Primary publication · 28339962 (PubMed)
  3. The novel adipokine/hepatokine fetuin B in severe human and murine diabetic kidney disease. Kralisch S, Hoffmann A, Klöting N, Bachmann A, Kratzsch J, Blüher M, Zhang MZ, Harris RC, Stumvoll M, Fasshauer M, Ebert T (2017) Diabetes Metab
    › Primary publication · 28214129 (PubMed)
  4. Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy. Wang X, Yao B, Wang Y, Fan X, Wang S, Niu A, Yang H, Fogo A, Zhang MZ, Harris RC (2017) Diabetes 66(2): 494-504
    › Primary publication · 27815317 (PubMed) · PMC5248989 (PubMed Central)
  5. IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury. Zhang MZ, Wang X, Wang Y, Niu A, Wang S, Zou C, Harris RC (2017) Kidney Int 91(2): 375-386
    › Primary publication · 27745702 (PubMed)
  6. Telomerase, Autophagy and Acute Kidney Injury. Harris RC, Cheng H (2016) Nephron 134(3): 145-148
    › Primary publication · 27376761 (PubMed)
  7. Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion. Zeng F, Kloepfer LA, Finney C, Diedrich A, Harris RC (2016) Am J Physiol Renal Physiol 311(4): F695-F707
    › Primary publication · 27226110 (PubMed) · PMC5142238 (PubMed Central)
  8. Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury. Skrypnyk NI, Voziyan P, Yang H, de Caestecker CR, Theberge MC, Drouin M, Hudson B, Harris RC, de Caestecker MP (2016) Am J Physiol Renal Physiol 311(2): F268-77
    › Primary publication · 27194713 (PubMed) · PMC5008672 (PubMed Central)
  9. Celebrating the ASN at 50. Harris RC, Ibrahim T, Nath KA (2016) J Am Soc Nephrol 27(6): 1575-6
    › Primary publication · 27142707 (PubMed) · PMC4884129 (PubMed Central)
  10. Novel methods for microCT-based analyses of vasculature in the renal cortex reveal a loss of perfusable arterioles and glomeruli in eNOS-/- mice. Perrien DS, Saleh MA, Takahashi K, Madhur MS, Harrison DG, Harris RC, Takahashi T (2016) BMC Nephrol : 24
    › Primary publication · 26936597 (PubMed) · PMC4776352 (PubMed Central)
  11. Antihypertensive mechanisms of intra-renal dopamine. Zhang MZ, Harris RC (2015) Curr Opin Nephrol Hypertens 24(2): 117-22
    › Primary publication · 25594544 (PubMed) · PMC4651846 (PubMed Central)
  12. EGF receptor deletion in podocytes attenuates diabetic nephropathy. Chen J, Chen JK, Harris RC (2015) J Am Soc Nephrol 26(5): 1115-25
    › Primary publication · 25185988 (PubMed) · PMC4413759 (PubMed Central)
  13. Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging. Wang F, Jiang R, Takahashi K, Gore J, Harris RC, Takahashi T, Quarles CC (2014) Magn Reson Imaging 32(9): 1125-32
    › Primary publication · 25093632 (PubMed) · PMC4171209 (PubMed Central)
  14. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM (2014) J Lipid Res 55(7): 1375-85
    › Primary publication · 24864273 (PubMed) · PMC4076088 (PubMed Central)
  15. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH (2014) J Clin Invest 124(6): 2396-409
    › Primary publication · 24789906 (PubMed) · PMC4092875 (PubMed Central)
  16. Renal endothelial dysfunction in diabetic nephropathy. Cheng H, Harris RC (2014) Cardiovasc Hematol Disord Drug Targets 14(1): 22-33
    › Primary publication · 24720460 (PubMed) · PMC4657140 (PubMed Central)
  17. Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. Zhang MZ, Wang Y, Paueksakon P, Harris RC (2014) Diabetes 63(6): 2063-72
    › Primary publication · 24705402 (PubMed) · PMC4030104 (PubMed Central)
  18. Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice. Zeng F, Miyazawa T, Kloepfer LA, Harris RC (2014) Kidney Int 86(3): 538-47
    › Primary publication · 24670412 (PubMed) · PMC4149866 (PubMed Central)
  19. Epidermal growth factor, from gene organization to bedside. Zeng F, Harris RC (2014) Semin Cell Dev Biol : 2-11
    › Primary publication · 24513230 (PubMed) · PMC4037350 (PubMed Central)
  20. The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R (2014) J Biol Chem 289(12): 8532-44
    › Primary publication · 24509849 (PubMed) · PMC3961677 (PubMed Central)
  21. The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. Capdevila JH, Pidkovka N, Mei S, Gong Y, Falck JR, Imig JD, Harris RC, Wang W (2014) J Biol Chem 289(7): 4377-86
    › Primary publication · 24368771 (PubMed) · PMC3924300 (PubMed Central)
  22. Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. Zhang MZ, Wang Y, Yao B, Gewin L, Wei S, Capdevila JH, Harris RC (2013) Am J Physiol Renal Physiol 305(12): F1680-6
    › Primary publication · 24154693 (PubMed) · PMC3882452 (PubMed Central)
  23. Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease. Wang F, Jiang RT, Tantawy MN, Borza DB, Takahashi K, Gore JC, Harris RC, Takahashi T, Quarles CC (2014) J Magn Reson Imaging 39(4): 866-71
    › Primary publication · 24006202 (PubMed) · PMC3858530 (PubMed Central)
  24. Ischemia-reperfusion model of acute kidney injury and post injury fibrosis in mice. Skrypnyk NI, Harris RC, de Caestecker MP (2013) J Vis Exp (78)
    › Primary publication · 23963468 (PubMed) · PMC3854859 (PubMed Central)
  25. Survivin mediates renal proximal tubule recovery from AKI. Chen J, Chen JK, Conway EM, Harris RC (2013) J Am Soc Nephrol 24(12): 2023-33
    › Primary publication · 23949800 (PubMed) · PMC3839548 (PubMed Central)
  26. Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney. Harris RC (2013) Trans Am Clin Climatol Assoc : 139-51
    › Primary publication · 23874018 (PubMed) · PMC3715909 (PubMed Central)
  27. Diabetic nephropathy: a national dialogue. Breyer MD, Coffman TM, Flessner MF, Fried LF, Harris RC, Ketchum CJ, Kretzler M, Nelson RG, Sedor JR, Susztak K, Kidney Research National Dialogue (KRND) (2013) Clin J Am Soc Nephrol 8(9): 1603-5
    › Primary publication · 23788618 (PubMed) · PMC3805071 (PubMed Central)
  28. Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression. Miyazawa T, Zeng F, Wang S, Fan X, Cheng H, Yang H, Bian A, Fogo AB, Harris RC (2013) Kidney Int 84(6): 1176-88
    › Citation · 23760291 (PubMed) · PMC3796048 (PubMed Central)
  29. Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis. Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X, Harris RC, Zhang MZ (2013) Mol Cancer Res 11(9): 1040-50
    › Primary publication · 23741059 (PubMed) · PMC3778073 (PubMed Central)
  30. Cyclooxygenase metabolites in the kidney. Harris RC, Zhang MZ (2011) Compr Physiol 1(4): 1729-58
    › Primary publication · 23733687 (PubMed)
  31. mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking. Chen J, Chen MX, Fogo AB, Harris RC, Chen JK (2013) J Am Soc Nephrol 24(2): 198-207
    › Primary publication · 23291473 (PubMed) · PMC3559479 (PubMed Central)
  32. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. Pidkovka N, Rao R, Mei S, Gong Y, Harris RC, Wang WH, Capdevila JH (2013) J Biol Chem 288(7): 5223-31
    › Primary publication · 23283969 (PubMed) · PMC3576126 (PubMed Central)
  33. The best-laid plans. Harris RC (2013) Am J Physiol Renal Physiol 304(8): F1086-7
    › Primary publication · 23269642 (PubMed) · PMC3625842 (PubMed Central)
  34. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy. Tantawy MN, Jiang R, Wang F, Takahashi K, Peterson TE, Zemel D, Hao CM, Fujita H, Harris RC, Quarles CC, Takahashi T (2012) BMC Nephrol : 168
    › Primary publication · 23228112 (PubMed) · PMC3542003 (PubMed Central)
  35. Deleting the TGF-β receptor attenuates acute proximal tubule injury. Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R (2012) J Am Soc Nephrol 23(12): 2001-11
    › Primary publication · 23160515 (PubMed) · PMC3507360 (PubMed Central)
  36. CSF-1 signaling mediates recovery from acute kidney injury. Zhang MZ, Yao B, Yang S, Jiang L, Wang S, Fan X, Yin H, Wong K, Miyazawa T, Chen J, Chang I, Singh A, Harris RC (2012) J Clin Invest 122(12): 4519-32
    › Primary publication · 23143303 (PubMed) · PMC3533529 (PubMed Central)
  37. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Hodgin JB, Nair V, Zhang H, Randolph A, Harris RC, Nelson RG, Weil EJ, Cavalcoli JD, Patel JM, Brosius FC, Kretzler M (2013) Diabetes 62(1): 299-308
    › Primary publication · 23139354 (PubMed) · PMC3526018 (PubMed Central)
  38. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Bartlett CS, Boyd KL, Harris RC, Zent R, Breyer RM (2012) Hypertension 60(5): 1184-91
    › Primary publication · 23006735 (PubMed) · PMC3478772 (PubMed Central)
  39. eNOS deficiency predisposes podocytes to injury in diabetes. Yuen DA, Stead BE, Zhang Y, White KE, Kabir MG, Thai K, Advani SL, Connelly KA, Takano T, Zhu L, Cox AJ, Kelly DJ, Gibson IW, Takahashi T, Harris RC, Advani A (2012) J Am Soc Nephrol 23(11): 1810-23
    › Primary publication · 22997257 (PubMed) · PMC3482727 (PubMed Central)
  40. Association of high blood pressure with renal insufficiency: role of albuminuria, from NHANES, 1999-2006. Yan P, Zhu X, Li H, Shrubsole MJ, Shi H, Zhang MZ, Harris RC, Hao CM, Dai Q (2012) PLoS One 7(7): e37837
    › Primary publication · 22802927 (PubMed) · PMC3388992 (PubMed Central)
  41. Podocyte ACE2 protects against diabetic nephropathy. Harris RC (2012) Kidney Int 82(3): 255-6
    › Primary publication · 22791320 (PubMed)
  42. Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R (2012) Kidney Int 82(9): 1000-9
    › Primary publication · 22785175 (PubMed) · PMC3472082 (PubMed Central)
  43. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Cheng H, Wang H, Fan X, Paueksakon P, Harris RC (2012) Kidney Int 82(11): 1176-83
    › Primary publication · 22785174 (PubMed) · PMC3473143 (PubMed Central)
  44. Intrarenal dopamine inhibits progression of diabetic nephropathy. Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC (2012) Diabetes 61(10): 2575-84
    › Primary publication · 22688335 (PubMed) · PMC3447896 (PubMed Central)
  45. SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice. Fujita H, Fujishima H, Takahashi K, Sato T, Shimizu T, Morii T, Shimizu T, Shirasawa T, Qi Z, Breyer MD, Harris RC, Yamada Y, Takahashi T (2012) Metabolism 61(12): 1714-24
    › Primary publication · 22632894 (PubMed) · PMC4360989 (PubMed Central)
  46. Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Jiang R, Wang S, Takahashi K, Fujita H, Fruci CR, Breyer MD, Harris RC, Takahashi T (2012) Genesis 50(9): 685-92
    › Primary publication · 22467476 (PubMed) · PMC3399989 (PubMed Central)
  47. Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Chen J, Chen JK, Harris RC (2012) Kidney Int 82(1): 45-52
    › Primary publication · 22418982 (PubMed) · PMC3376190 (PubMed Central)
  48. Dopamine, the kidney, and hypertension. Harris RC, Zhang MZ (2012) Curr Hypertens Rep 14(2): 138-43
    › Primary publication · 22407378 (PubMed) · PMC3742329 (PubMed Central)
  49. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ (2012) Eur J Cell Biol 91(3): 180-91
    › Primary publication · 22306379 (PubMed) · PMC3629562 (PubMed Central)
  50. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A (2012) Kidney Int 81(11): 1086-97
    › Primary publication · 22297672 (PubMed) · PMC3345314 (PubMed Central)
  51. Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Chen J, Chen JK, Harris RC (2012) Mol Cell Biol 32(5): 981-91
    › Primary publication · 22215616 (PubMed) · PMC3295195 (PubMed Central)
  52. Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury. Yang S, Yao B, Zhou Y, Yin H, Zhang MZ, Harris RC (2012) Am J Physiol Renal Physiol 302(6): F742-9
    › Primary publication · 22169008 (PubMed) · PMC3311314 (PubMed Central)
  53. Abnormalities in renal dopamine signaling and hypertension: the role of GRK4. Harris RC (2012) Curr Opin Nephrol Hypertens 21(1): 61-5
    › Primary publication · 22123211 (PubMed) · PMC3286360 (PubMed Central)
  54. Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS-/- db/db mice. Zhang MZ, Wang S, Yang S, Yang H, Fan X, Takahashi T, Harris RC (2012) Am J Physiol Renal Physiol 302(4): F433-8
    › Primary publication · 22114203 (PubMed) · PMC3289417 (PubMed Central)
  55. EGFR signaling promotes TGFβ-dependent renal fibrosis. Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC (2012) J Am Soc Nephrol 23(2): 215-24
    › Primary publication · 22095949 (PubMed) · PMC3269185 (PubMed Central)
  56. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. Cheng H, Fan X, Moeckel GW, Harris RC (2011) J Am Soc Nephrol 22(7): 1240-51
    › Primary publication · 21737546 (PubMed) · PMC3137572 (PubMed Central)
  57. Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. Zhang MZ, Yao B, Wang S, Fan X, Wu G, Yang H, Yin H, Yang S, Harris RC (2011) J Clin Invest 121(7): 2845-54
    › Primary publication · 21701066 (PubMed) · PMC3223841 (PubMed Central)
  58. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB (2011) Oncogene 30(29): 3234-47
    › Primary publication · 21383692 (PubMed) · PMC3591522 (PubMed Central)
  59. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R (2010) J Am Soc Nephrol 21(8): 1334-43
    › Primary publication · 20576806 (PubMed) · PMC2938601 (PubMed Central)
  60. The glomerulus--a view from the outside--the podocyte. Cheng H, Harris RC (2010) Int J Biochem Cell Biol 42(9): 1380-7
    › Primary publication · 20542138 (PubMed) · PMC2910191 (PubMed Central)
  61. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A (2010) Mol Cell Biol 30(12): 3048-58
    › Primary publication · 20368353 (PubMed) · PMC2876688 (PubMed Central)
  62. Macula densa sensing and signaling mechanisms of renin release. Peti-Peterdi J, Harris RC (2010) J Am Soc Nephrol 21(7): 1093-6
    › Primary publication · 20360309 (PubMed) · PMC4577295 (PubMed Central)
  63. Sirt1 activation protects the mouse renal medulla from oxidative injury. He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM (2010) J Clin Invest 120(4): 1056-68
    › Primary publication · 20335659 (PubMed) · PMC2846063 (PubMed Central)
  64. Assessing the application of tissue microarray technology to kidney research. Zhang MZ, Su Y, Yao B, Zheng W, Decaestecker M, Harris RC (2010) J Histochem Cytochem 58(5): 413-20
    › Primary publication · 20086233 (PubMed) · PMC2857813 (PubMed Central)
  65. GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. Rao R, Patel S, Hao C, Woodgett J, Harris R (2010) J Am Soc Nephrol 21(3): 428-37
    › Primary publication · 20056751 (PubMed) · PMC2831860 (PubMed Central)
  66. Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. Yao B, Harris RC, Zhang MZ (2009) Hypertension 54(5): 1077-83
    › Primary publication · 19770404 (PubMed) · PMC2782522 (PubMed Central)
  67. Mouse models of diabetic nephropathy. Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T, Animal Models of Diabetic Complications Consortium (2009) J Am Soc Nephrol 20(12): 2503-12
    › Primary publication · 19729434 (PubMed) · PMC4075053 (PubMed Central)
  68. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R (2009) Development 136(19): 3357-66
    › Primary publication · 19710172 (PubMed) · PMC2739149 (PubMed Central)
  69. Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas. Ray KC, Blaine SA, Washington MK, Braun AH, Singh AB, Harris RC, Harding PA, Coffey RJ, Means AL (2009) Gastroenterology 137(5): 1785-94
    › Primary publication · 19689925 (PubMed) · PMC2767440 (PubMed Central)
  70. Distinct roles for basal and induced COX-2 in podocyte injury. Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC (2009) J Am Soc Nephrol 20(9): 1953-62
    › Primary publication · 19643929 (PubMed) · PMC2736764 (PubMed Central)
  71. S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Chen JK, Chen J, Thomas G, Kozma SC, Harris RC (2009) Am J Physiol Renal Physiol 297(3): F585-93
    › Primary publication · 19474189 (PubMed) · PMC2739710 (PubMed Central)
  72. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. Fujita H, Fujishima H, Chida S, Takahashi K, Qi Z, Kanetsuna Y, Breyer MD, Harris RC, Yamada Y, Takahashi T (2009) J Am Soc Nephrol 20(6): 1303-13
    › Primary publication · 19470681 (PubMed) · PMC2689908 (PubMed Central)
  73. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC (2009) J Clin Invest 119(4): 876-85
    › Primary publication · 19307727 (PubMed) · PMC2662561 (PubMed Central)
  74. Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2. Smith JP, Pozzi A, Dhawan P, Singh AB, Harris RC (2009) Am J Physiol Renal Physiol 296(5): F957-65
    › Primary publication · 19244405 (PubMed) · PMC2681361 (PubMed Central)
  75. Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells. Zeng F, Xu J, Harris RC (2009) FASEB J 23(6): 1935-45
    › Primary publication · 19193720 (PubMed) · PMC2698660 (PubMed Central)
  76. Intrarenal dopaminergic system regulates renin expression. Zhang MZ, Yao B, Fang X, Wang S, Smith JP, Harris RC (2009) Hypertension 53(3): 564-70
    › Primary publication · 19139376 (PubMed) · PMC2680004 (PubMed Central)
  77. The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Zeng F, Singh AB, Harris RC (2009) Exp Cell Res 315(4): 602-10
    › Primary publication · 18761338 (PubMed) · PMC2654782 (PubMed Central)
  78. Single amino acid substitution in aquaporin 11 causes renal failure. Tchekneva EE, Khuchua Z, Davis LS, Kadkina V, Dunn SR, Bachman S, Ishibashi K, Rinchik EM, Harris RC, Dikov MM, Breyer MD (2008) J Am Soc Nephrol 19(10): 1955-64
    › Primary publication · 18701606 (PubMed) · PMC2551576 (PubMed Central)
  79. Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c. Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, Ebrahim B, Harris RC, Kern TS, Wasserman DH, Breyer MD, Qi Z (2008) Am J Physiol Endocrinol Metab 295(4): E981-6
    › Primary publication · 18664598 (PubMed) · PMC2575908 (PubMed Central)
  80. Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. Chen JK, Chen J, Imig JD, Wei S, Hachey DL, Guthi JS, Falck JR, Capdevila JH, Harris RC (2008) J Biol Chem 283(36): 24514-24
    › Primary publication · 18606824 (PubMed) · PMC2528993 (PubMed Central)
  81. Apoptosis of the thick ascending limb results in acute kidney injury. Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD (2008) J Am Soc Nephrol 19(8): 1538-46
    › Primary publication · 18495962 (PubMed) · PMC2488270 (PubMed Central)
  82. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R (2008) Dev Biol 316(2): 288-301
    › Primary publication · 18328474 (PubMed) · PMC2396524 (PubMed Central)
  83. Examining diabetic nephropathy through the lens of mouse genetics. Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Harris RC (2007) Curr Diab Rep 7(6): 459-66
    › Primary publication · 18255011 (PubMed)
  84. Insight into the genetics of diabetic nephropathy through the study of mice. Breyer MD, Qi Z, Tchekneva EE, Harris RC (2008) Curr Opin Nephrol Hypertens 17(1): 82-6
    › Primary publication · 18090675 (PubMed)
  85. An update on cyclooxygenase-2 expression and metabolites in the kidney. Harris RC (2008) Curr Opin Nephrol Hypertens 17(1): 64-9
    › Primary publication · 18090672 (PubMed)
  86. Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase. Yao B, Xu J, Harris RC, Zhang MZ (2008) Am J Physiol Renal Physiol 294(2): F433-9
    › Primary publication · 18057186 (PubMed)
  87. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC (2007) Nephron Exp Nephrol 107(3): e87-94
    › Primary publication · 17890881 (PubMed)
  88. Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Singh AB, Sugimoto K, Dhawan P, Harris RC (2007) Am J Physiol Cell Physiol 293(5): C1660-8
    › Primary publication · 17855771 (PubMed)
  89. Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype. Singh AB, Sugimoto K, Harris RC (2007) J Biol Chem 282(45): 32890-901
    › Primary publication · 17848576 (PubMed)
  90. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Zeng F, Zhang MZ, Singh AB, Zent R, Harris RC (2007) Mol Biol Cell 18(11): 4446-56
    › Primary publication · 17761534 (PubMed) · PMC2043549 (PubMed Central)
  91. Characterization of a putative intrarenal serotonergic system. Xu J, Yao B, Fan X, Langworthy MM, Zhang MZ, Harris RC (2007) Am J Physiol Renal Physiol 293(5): F1468-75
    › Primary publication · 17715266 (PubMed)
  92. Update on cyclooxygenase-2 inhibitors. Harris RC, Breyer MD (2006) Clin J Am Soc Nephrol 1(2): 236-45
    › Primary publication · 17699212 (PubMed)
  93. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Kanetsuna Y, Takahashi K, Nagata M, Gannon MA, Breyer MD, Harris RC, Takahashi T (2007) Am J Pathol 170(5): 1473-84
    › Primary publication · 17456755 (PubMed) · PMC1854944 (PubMed Central)
  94. Genetics of diabetic nephropathy: lessons from mice. Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Zhao HJ, Harris RC (2007) Semin Nephrol 27(2): 237-47
    › Primary publication · 17418691 (PubMed)
  95. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A (2007) Mol Cell Biol 27(9): 3313-26
    › Primary publication · 17339338 (PubMed) · PMC1899972 (PubMed Central)
  96. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Chen J, Chen JK, Falck JR, Guthi JS, Anjaiah S, Capdevila JH, Harris RC (2007) Mol Cell Biol 27(8): 3023-34
    › Primary publication · 17283047 (PubMed) · PMC1899952 (PubMed Central)
  97. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC (2007) J Am Soc Nephrol 18(2): 551-9
    › Primary publication · 17202413 (PubMed)
  98. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Zhang MZ, Yao B, Cheng HF, Wang SW, Inagami T, Harris RC (2006) Proc Natl Acad Sci U S A 103(43): 16045-50
    › Primary publication · 17043228 (PubMed) · PMC1635124 (PubMed Central)
  99. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. Zhao HJ, Wang S, Cheng H, Zhang MZ, Takahashi T, Fogo AB, Breyer MD, Harris RC (2006) J Am Soc Nephrol 17(10): 2664-9
    › Primary publication · 16971655 (PubMed) · PMC4618687 (PubMed Central)
  100. Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers. Cheng H, Harris RC (2006) Expert Opin Drug Saf 5(5): 631-41
    › Primary publication · 16907653 (PubMed)
  101. COX-2 and the kidney. Harris RC (2006) J Cardiovasc Pharmacol : S37-42
    › Primary publication · 16785827 (PubMed)
  102. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Kanetsuna Y, Hirano K, Nagata M, Gannon MA, Takahashi K, Harris RC, Breyer MD, Takahashi T (2006) Am J Physiol Renal Physiol 291(6): F1315-22
    › Primary publication · 16705146 (PubMed)
  103. Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. Chen J, Chen JK, Neilson EG, Harris RC (2006) J Am Soc Nephrol 17(6): 1615-23
    › Primary publication · 16641152 (PubMed)
  104. Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. Yao B, Xu J, Qi Z, Harris RC, Zhang MZ (2006) Am J Physiol Renal Physiol 291(2): F368-74
    › Primary publication · 16597606 (PubMed)
  105. Toward a unified theory of renal progression. Harris RC, Neilson EG (2006) Annu Rev Med : 365-80
    › Primary publication · 16409155 (PubMed)
  106. Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway. Cheng HF, Zhang MZ, Harris RC (2006) Am J Physiol Renal Physiol 290(6): F1391-7
    › Primary publication · 16380459 (PubMed)
  107. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC (2005) Nephron Exp Nephrol 101(3): e75-85
    › Primary publication · 15995341 (PubMed)
  108. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB, Harris RC (2005) Cell Signal 17(10): 1183-93
    › Primary publication · 15982853 (PubMed)
  109. Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. Cheng HF, Harris RC (2005) Curr Pharm Des 11(14): 1795-804
    › Primary publication · 15892676 (PubMed)
  110. Diabetic nephropathy: of mice and men. Breyer MD, Böttinger E, Brosius FC, Coffman TM, Fogo A, Harris RC, Heilig CW, Sharma K (2005) Adv Chronic Kidney Dis 12(2): 128-45
    › Primary publication · 15822049 (PubMed)
  111. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. Chen JK, Chen J, Neilson EG, Harris RC (2005) J Am Soc Nephrol 16(5): 1384-91
    › Primary publication · 15788477 (PubMed)
  112. Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Yao B, Harris RC, Zhang MZ (2005) Am J Physiol Regul Integr Comp Physiol 288(6): R1767-73
    › Primary publication · 15718388 (PubMed)
  113. Are all COX-2 inhibitors created equal? Chang IJ, Harris RC (2005) Hypertension 45(2): 178-80
    › Primary publication · 15623540 (PubMed)
  114. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. Zhang MZ, Yao B, McKanna JA, Harris RC (2005) Am J Physiol Renal Physiol 288(4): F840-5
    › Primary publication · 15613619 (PubMed)
  115. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Rao R, Zhang MZ, Zhao M, Cai H, Harris RC, Breyer MD, Hao CM (2005) Am J Physiol Renal Physiol 288(4): F642-9
    › Primary publication · 15585669 (PubMed)
  116. Mouse models of diabetic nephropathy. Breyer MD, Böttinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K, AMDCC (2005) J Am Soc Nephrol 16(1): 27-45
    › Primary publication · 15563560 (PubMed)
  117. EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. Shivakumar BR, Wang Z, Hammond TG, Harris RC (2005) Cell Biochem Funct 23(3): 195-204
    › Primary publication · 15376229 (PubMed)
  118. Cyclooxygenase-2 and the renal renin-angiotensin system. Harris RC, Zhang MZ, Cheng HF (2004) Acta Physiol Scand 181(4): 543-7
    › Primary publication · 15283769 (PubMed)
  119. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A (2004) Am J Pathol 165(2): 617-30
    › Primary publication · 15277235 (PubMed) · PMC1618576 (PubMed Central)
  120. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R (2004) Am J Physiol Renal Physiol 287(4): F602-11
    › Primary publication · 15187002 (PubMed)
  121. Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD (2004) Kidney Int 65(4): 1205-13
    › Primary publication · 15086459 (PubMed)
  122. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. Singh AB, Tsukada T, Zent R, Harris RC (2004) J Cell Sci 117(Pt 8): 1365-79
    › Primary publication · 14996914 (PubMed)
  123. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G (2004) Proc Natl Acad Sci U S A 101(8): 2311-6
    › Primary publication · 14983006 (PubMed) · PMC356947 (PubMed Central)
  124. The type 1 angiotensin II receptor tail affects receptor targeting, internalization, and membrane fusion properties. Becker BN, Cheng HF, Hammond TG, Harris RC (2004) Mol Pharmacol 65(2): 362-9
    › Primary publication · 14742678 (PubMed)
  125. Cyclooxygenases, the kidney, and hypertension. Cheng HF, Harris RC (2004) Hypertension 43(3): 525-30
    › Primary publication · 14732722 (PubMed)
  126. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Zhang MZ, Sanchez Lopez P, McKanna JA, Harris RC (2004) Endocrinology 145(3): 1402-9
    › Primary publication · 14684611 (PubMed)
  127. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC (2003) J Am Soc Nephrol 14(12): 3147-54
    › Primary publication · 14638913 (PubMed)
  128. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Qi Z, Whitt I, Mehta A, Jin J, Zhao M, Harris RC, Fogo AB, Breyer MD (2004) Am J Physiol Renal Physiol 286(3): F590-6
    › Primary publication · 14600035 (PubMed)
  129. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. Singh AB, Harris RC (2004) J Biol Chem 279(5): 3543-52
    › Primary publication · 14593119 (PubMed)
  130. Regulation of renal cortical cyclooxygenase-2 in young rats. Zhang MZ, Wang SW, Cheng H, Zhang Y, McKanna JA, Harris RC (2003) Am J Physiol Renal Physiol 285(5): F881-8
    › Primary publication · 12851252 (PubMed)
  131. Cyclooxygenase-2 and the kidney: functional and pathophysiological implications. Harris RC (2002) J Hypertens Suppl 20(6): S3-9
    › Primary publication · 12683421 (PubMed)
  132. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD (2003) Gastroenterology 124(4): 1020-36
    › Primary publication · 12671899 (PubMed)
  133. EGF receptor ligands. Harris RC, Chung E, Coffey RJ (2003) Exp Cell Res 284(1): 2-13
    › Primary publication · 12648462 (PubMed)
  134. Interactions between COX-2 and the renin-angiotensin system in the kidney. Harris RC (2003) Acta Physiol Scand 177(4): 423-7
    › Primary publication · 12648159 (PubMed)
  135. Does cyclooxygenase-2 affect blood pressure? Cheng HF, Harris RC (2003) Curr Hypertens Rep 5(1): 87-92
    › Primary publication · 12530941 (PubMed)
  136. Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. Cheng HF, Harris RC (2002) J Biol Chem 277(47): 45638-43
    › Primary publication · 12237297 (PubMed)
  137. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Cheng HF, Wang SW, Zhang MZ, McKanna JA, Breyer R, Harris RC (2002) Am J Physiol Regul Integr Comp Physiol 283(3): R638-46
    › Primary publication · 12184998 (PubMed)
  138. Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Zhang MZ, Hao CM, Breyer MD, Harris RC, McKanna JA (2002) Am J Physiol Renal Physiol 283(3): F509-16
    › Primary publication · 12167602 (PubMed)
  139. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA, Harris RC (2002) Kidney Int 62(3): 929-39
    › Primary publication · 12164875 (PubMed)
  140. Microsomal cytochrome P450 and eicosanoid metabolism. Capdevila JH, Harris RC, Falck JR (2002) Cell Mol Life Sci 59(5): 780-9
    › Primary publication · 12088278 (PubMed)
  141. Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching. Takemura T, Hino S, Okada M, Murata Y, Yanagida H, Ikeda M, Yoshioka K, Harris RC (2002) Kidney Int 61(6): 1968-79
    › Primary publication · 12028437 (PubMed)
  142. Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Chen JK, Capdevila J, Harris RC (2002) Proc Natl Acad Sci U S A 99(9): 6029-34
    › Primary publication · 11983897 (PubMed) · PMC122896 (PubMed Central)
  143. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD, Fazio S, Linton MF (2002) Circulation 105(15): 1816-23
    › Primary publication · 11956125 (PubMed)
  144. Cyclooxygenase-2 inhibition and renal physiology. Harris RC (2002) Am J Cardiol 89(6A): 10D-17D
    › Primary publication · 11909556 (PubMed)
  145. Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Chen JK, Capdevila J, Harris RC (2001) Mol Cell Biol 21(18): 6322-31
    › Primary publication · 11509673 (PubMed) · PMC87364 (PubMed Central)
  146. Physiological regulation of cyclooxygenase-2 in the kidney. Harris RC, Breyer MD (2001) Am J Physiol Renal Physiol 281(1): F1-11
    › Primary publication · 11399641 (PubMed)
  147. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Chen JK, Zimpelmann J, Harris RC, Burns KD (2001) Am J Physiol Renal Physiol 280(6): F980-8
    › Primary publication · 11352837 (PubMed)
  148. Induction of collecting duct morphogenesis in vitro by heparin-binding epidermal growth factor-like growth factor. Takemura T, Hino S, Kuwajima H, Yanagida H, Okada M, Nagata M, Sasaki S, Barasch J, Harris RC, Yoshioka K (2001) J Am Soc Nephrol 12(5): 964-72
    › Primary publication · 11316855 (PubMed)
  149. Cyclooxygenase 2 and the kidney. Breyer MD, Harris RC (2001) Curr Opin Nephrol Hypertens 10(1): 89-98
    › Primary publication · 11195058 (PubMed)
  150. Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Cheng HF, Wang JL, Zhang MZ, Wang SW, McKanna JA, Harris RC (2001) Am J Physiol Renal Physiol 280(3): F449-56
    › Primary publication · 11181406 (PubMed)
  151. Cyclooxygenase-2 in the kidney. Harris RC (2000) J Am Soc Nephrol 11(12): 2387-94
    › Primary publication · 11095663 (PubMed)
  152. Oxidant stress activates AP-1 and heparin-binding epidermal growth factor-like growth factor transcription in renal epithelial cells. Sakai M, Tsukada T, Harris RC (2001) Exp Nephrol 9(1): 28-39
    › Primary publication · 11053978 (PubMed)
  153. Macula densa signalling--a potential role of cyclooxygenase-2 (COX-2)? Harris RC (2000) Nephrol Dial Transplant 15(10): 1504-6
    › Primary publication · 11007811 (PubMed)
  154. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC (2000) J Clin Invest 106(5): 681-8
    › Primary publication · 10974021 (PubMed) · PMC381289 (PubMed Central)
  155. EGF receptor activation by G-protein coupled receptors. Harris RC (2000) Kidney Int 58(2): 898-9
    › Primary publication · 10916116 (PubMed)
  156. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC (2000) Am J Physiol Renal Physiol 279(1): F122-9
    › Primary publication · 10894794 (PubMed)
  157. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Wang JL, Cheng HF, Shappell S, Harris RC (2000) Kidney Int 57(6): 2334-42
    › Primary publication · 10844603 (PubMed)
  158. Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. Chen JK, Capdevila J, Harris RC (2000) J Biol Chem 275(18): 13789-92
    › Primary publication · 10788500 (PubMed)
  159. Characterization of the collagen phenotype of rabbit proximal tubule cells in culture. Gibbs SR, Goins RA, Belvin EL, Dimari SJ, Merriam AP, Bowling-Brown S, Harris RC, Haralson MA (1999) Connect Tissue Res 40(3): 173-88
    › Primary publication · 10772539 (PubMed)
  160. Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Harris RC, Cheng H, Wang J, Zhang M, McKanna JA (2000) Acta Physiol Scand 168(1): 47-51
    › Primary publication · 10691779 (PubMed)
  161. Effects of epidermal growth factor on collagen expression by rat kidney mesangial cells in culture. Haralson MA, DiMari SJ, Hoover RL, Harris RC (2000) Matrix Biol 19(1): 47-59
    › Primary publication · 10686425 (PubMed)
  162. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. Capdevila JH, Falck JR, Harris RC (2000) J Lipid Res 41(2): 163-81
    › Primary publication · 10681399 (PubMed)
  163. Ischemic acute renal failure induces differential expression of small heat shock proteins. Smoyer WE, Ransom R, Harris RC, Welsh MJ, Lutsch G, Benndorf R (2000) J Am Soc Nephrol 11(2): 211-21
    › Primary publication · 10665928 (PubMed)
  164. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kömhoff M, Wang JL, Cheng HF, Langenbach R, McKanna JA, Harris RC, Breyer MD (2000) Kidney Int 57(2): 414-22
    › Primary publication · 10652018 (PubMed)
  165. Potential mechanisms and physiologic actions of intracellular angiotensin II. Harris RC (1999) Am J Med Sci 318(6): 374-9
    › Primary publication · 10616162 (PubMed)
  166. Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Zhang MZ, Harris RC, McKanna JA (1999) Proc Natl Acad Sci U S A 96(26): 15280-5
    › Primary publication · 10611376 (PubMed) · PMC24811 (PubMed Central)
  167. Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. Becker BN, Kondo S, Chen JK, Harris RC (1999) J Recept Signal Transduct Res 19(6): 975-93
    › Primary publication · 10533984 (PubMed)
  168. Molecular basis of injury and progression in focal glomerulosclerosis. Harris RC (1999) Nephron 82(4): 289-99
    › Primary publication · 10450030 (PubMed)
  169. Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Wang JL, Cheng HF, Harris RC (1999) Hypertension 34(1): 96-101
    › Primary publication · 10406830 (PubMed)
  170. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. Cheng HF, Wang JL, Zhang MZ, Miyazaki Y, Ichikawa I, McKanna JA, Harris RC (1999) J Clin Invest 103(7): 953-61
    › Primary publication · 10194467 (PubMed) · PMC408259 (PubMed Central)
  171. Integrins and the cytoskeleton: focal adhesion kinase and paxillin. Yasuda T, Kondo S, Owada S, Ishida M, Harris RC (1999) Nephrol Dial Transplant : 58-60
    › Primary publication · 10048453 (PubMed)
  172. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. Chen JK, Wang DW, Falck JR, Capdevila J, Harris RC (1999) J Biol Chem 274(8): 4764-9
    › Primary publication · 9988714 (PubMed)
  173. Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Takemura T, Hino S, Murata Y, Yanagida H, Okada M, Yoshioka K, Harris RC (1999) Kidney Int 55(1): 71-81
    › Primary publication · 9893115 (PubMed)
  174. Angiotensin induces the urinary peristaltic machinery during the perinatal period. Miyazaki Y, Tsuchida S, Nishimura H, Pope JC, Harris RC, McKanna JM, Inagami T, Hogan BL, Fogo A, Ichikawa I (1998) J Clin Invest 102(8): 1489-97
    › Primary publication · 9788961 (PubMed) · PMC508998 (PubMed Central)
  175. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. Chen JK, Falck JR, Reddy KM, Capdevila J, Harris RC (1998) J Biol Chem 273(44): 29254-61
    › Primary publication · 9786938 (PubMed)
  176. Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Wang JL, Cheng HF, Zhang MZ, McKanna JA, Harris RC (1998) Am J Physiol 275(4 Pt 2): F613-22
    › Primary publication · 9755133 (PubMed)
  177. Prostaglandins in macula densa function. Harris RC, Wang JL, Cheng HF, Zhang MZ, McKanna JA (1998) Kidney Int Suppl : S49-52
    › Primary publication · 9736253 (PubMed)
  178. Constitutive expression of cyclooxygenase-2 in rat vas deferens. McKanna JA, Zhang MZ, Wang JL, Cheng H, Harris RC (1998) Am J Physiol 275(1 Pt 2): R227-33
    › Primary publication · 9688983 (PubMed)
  179. Mechanical stretch/relaxation stimulates a cellular renin-angiotensin system in cultured rat mesangial cells. Becker BN, Yasuda T, Kondo S, Vaikunth S, Homma T, Harris RC (1998) Exp Nephrol 6(1): 57-66
    › Primary publication · 9523174 (PubMed)
  180. Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule. Cheng HF, Wang JL, Vinson GP, Harris RC (1998) Am J Physiol 274(1 Pt 2): F10-7
    › Primary publication · 9458818 (PubMed)
  181. Cyclooxygenase-2 in rat nephron development. Zhang MZ, Wang JL, Cheng HF, Harris RC, McKanna JA (1997) Am J Physiol 273(6 Pt 2): F994-1002
    › Primary publication · 9435689 (PubMed)
  182. The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. Takemura T, Kondo S, Homma T, Sakai M, Harris RC (1997) J Biol Chem 272(49): 31036-42
    › Primary publication · 9388253 (PubMed)
  183. Apical ANG II-stimulated PLA2 activity and Na+ flux: a potential role for Ca2+-independent PLA2. Becker BN, Cheng HF, Harris RC (1997) Am J Physiol 273(4 Pt 2): F554-62
    › Primary publication · 9362333 (PubMed)
  184. Mechanical stress-cell function relationships in renal cells. Harris RC, Kondo S, Yasuda T (1997) Exp Nephrol 5(4): 263-70
    › Primary publication · 9259179 (PubMed)
  185. Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Becker BN, Kondo S, Cheng HF, Harris RC (1997) Kidney Int 52(1): 87-92
    › Primary publication · 9211350 (PubMed)
  186. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. Sakai M, Zhang M, Homma T, Garrick B, Abraham JA, McKanna JA, Harris RC (1997) J Clin Invest 99(9): 2128-38
    › Primary publication · 9151785 (PubMed) · PMC508043 (PubMed Central)
  187. Growth factors and cytokines in acute renal failure. Harris RC (1997) Adv Ren Replace Ther 4(2 Suppl 1): 43-53
    › Primary publication · 9113240 (PubMed)
  188. Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. Harris RC, Becker BN, Cheng HF (1997) J Am Soc Nephrol 8(2): 306-13
    › Primary publication · 9048351 (PubMed)
  189. The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Harris RC, Cheng HF (1996) Exp Nephrol : 2-7
    › Primary publication · 9001891 (PubMed)
  190. A potential mechanism for proximal tubule angiotensin II-mediated sodium flux associated with receptor-mediated endocytosis and arachidonic acid release. Becker BN, Harris RC (1996) Kidney Int Suppl : S66-72
    › Primary publication · 8941925 (PubMed)
  191. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. Yasuda T, Kondo S, Homma T, Harris RC (1996) J Clin Invest 98(9): 1991-2000
    › Primary publication · 8903317 (PubMed) · PMC507642 (PubMed Central)
  192. The macula densa: recent developments. Harris RC (1996) J Hypertens 14(7): 815-22
    › Primary publication · 8818919 (PubMed)
  193. Alteration of cellular function in rat mesangial cells in response to mechanical stretch relaxation. Yasuda T, Akai Y, Kondo S, Becker BN, Homma T, Owada S, Ishida M, Harris RC (1996) Contrib Nephrol : 222-8
    › Primary publication · 8744061 (PubMed)
  194. Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule. Cheng HF, Becker BN, Harris RC (1996) J Clin Invest 97(12): 2745-52
    › Primary publication · 8675685 (PubMed) · PMC507367 (PubMed Central)
  195. Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. Homma T, Zhang JY, Shimizu T, Prakash C, Blair IA, Harris RC (1993) Biochem Biophys Res Commun 191(1): 282-8
    › Primary publication · 8447831 (PubMed)
  196. The intrarenal renin-angiotensin system. Burns KD, Homma T, Harris RC (1993) Semin Nephrol 13(1): 13-30
    › Primary publication · 8434183 (PubMed)
  197. Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. Takahashi K, Harris RC, Capdevila JH, Karara A, Makita K, Jacobson HR, Munger KA, Badr KF (1993) J Am Soc Nephrol 3(8): 1496-500
    › Primary publication · 8387830 (PubMed)
  198. Hepatocyte growth factor stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Harris RC, Burns KD, Alattar M, Homma T, Nakamura T (1993) Life Sci 52(13): 1091-100
    › Primary publication · 8383782 (PubMed)
  199. The role of physical forces in alterations of mesangial cell function. Harris RC, Akai Y, Yasuda T, Homma T (1994) Kidney Int Suppl : S17-21
    › Primary publication · 8158889 (PubMed)
  200. Extrarenal complications of the nephrotic syndrome. Harris RC, Ismail N (1994) Am J Kidney Dis 23(4): 477-97
    › Primary publication · 8154483 (PubMed)
  201. Role of physical factors in the regulation of mesangial cell growth and the interaction with vasoactive agents. Harris RC, Akai Y, Yasuda T, Homma T (1994) Exp Nephrol 2(2): 104
    › Primary publication · 8082000 (PubMed)
  202. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Akai Y, Homma T, Burns KD, Yasuda T, Badr KF, Harris RC (1994) Am J Physiol 267(2 Pt 1): C482-90
    › Primary publication · 8074183 (PubMed)
  203. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD (1994) J Clin Invest 94(6): 2504-10
    › Primary publication · 7989609 (PubMed) · PMC330084 (PubMed Central)
  204. Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Burns KD, Inagami T, Harris RC (1993) Am J Physiol 264(4 Pt 2): F645-54
    › Primary publication · 7916579 (PubMed)
  205. Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. Cheng HF, Becker BN, Burns KD, Harris RC (1995) J Clin Invest 95(5): 2012-9
    › Primary publication · 7738168 (PubMed) · PMC295780 (PubMed Central)
  206. Signaling and growth responses of LLC-PK1/Cl4 cells transfected with the rabbit AT1 ANG II receptor. Burns KD, Harris RC (1995) Am J Physiol 268(4 Pt 1): C925-35
    › Primary publication · 7733240 (PubMed)
  207. Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus. Cheng HF, Burns KD, Harris RC (1994) Kidney Int 46(6): 1603-10
    › Primary publication · 7700017 (PubMed)
  208. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ, Harris RC (1995) J Clin Invest 96(2): 1018-25
    › Primary publication · 7635938 (PubMed) · PMC185290 (PubMed Central)
  209. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC (1995) Science 269(5221): 230-4
    › Primary publication · 7618084 (PubMed)
  210. Angiotensin II-mediated renal injury. Harris RC, Martinez-Maldonado M (1995) Miner Electrolyte Metab 21(4-5): 328-35
    › Primary publication · 7565481 (PubMed)
  211. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. Burns KD, Capdevila J, Wei S, Breyer MD, Homma T, Harris RC (1995) Am J Physiol 269(4 Pt 1): C831-40
    › Primary publication · 7485450 (PubMed)
  212. Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Becker BN, Cheng HF, Burns KD, Harris RC (1995) Am J Physiol 269(4 Pt 1): C1048-56
    › Primary publication · 7485445 (PubMed)
  213. Adaptation of Na+-H+ exchange in renal microvillus membrane vesicles. Role of dietary protein and uninephrectomy. Harris RC, Seifter JL, Brenner BM (1984) J Clin Invest 74(6): 1979-87
    › Primary publication · 6511911 (PubMed) · PMC425385 (PubMed Central)
  214. Evidence for glomerular actions of epidermal growth factor in the rat. Harris RC, Hoover RL, Jacobson HR, Badr KF (1988) J Clin Invest 82(3): 1028-39
    › Primary publication · 3262122 (PubMed) · PMC303617 (PubMed Central)
  215. Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus. Harris RC, Brenner BM, Seifter JL (1986) J Clin Invest 77(3): 724-33
    › Primary publication · 3005362 (PubMed) · PMC423456 (PubMed Central)
  216. Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. Badr KF, DeBoer DK, Takahashi K, Harris RC, Fogo A, Jacobson HR (1989) Am J Physiol 256(1 Pt 2): F35-43
    › Primary publication · 2912165 (PubMed)
  217. Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. Harris RC, Daniel TO (1989) J Cell Physiol 139(2): 383-91
    › Primary publication · 2785525 (PubMed)
  218. Leukotriene D4 binding and signal transduction in rat glomerular mesangial cells. Badr KF, Mong S, Hoover RL, Schwartzberg M, Ebert J, Jacobson HR, Harris RC (1989) Am J Physiol 257(2 Pt 2): F280-7
    › Primary publication · 2548402 (PubMed)
  219. Response of rat inner medullary collecting duct to epidermal growth factor. Harris RC (1989) Am J Physiol 256(6 Pt 2): F1117-24
    › Primary publication · 2544106 (PubMed)
  220. Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. Badr KF, Murray JJ, Breyer MD, Takahashi K, Inagami T, Harris RC (1989) J Clin Invest 83(1): 336-42
    › Primary publication · 2536045 (PubMed) · PMC303681 (PubMed Central)
  221. Coupling of Na-H exchange and Na-K pump activity in cultured rat proximal tubule cells. Harris RC, Seifter JL, Lechene C (1986) Am J Physiol 251(5 Pt 1): C815-24
    › Primary publication · 2430465 (PubMed)
  222. Changes in gene expression after temporary renal ischemia. Safirstein R, Price PM, Saggi SJ, Harris RC (1990) Kidney Int 37(6): 1515-21
    › Primary publication · 2362405 (PubMed)
  223. Loop diuretic-sensitive potassium flux pathways of rat glomerular mesangial cells. Homma T, Hoover RL, Harris RC (1990) Am J Physiol 258(5 Pt 1): C862-70
    › Primary publication · 2333983 (PubMed)
  224. Agonist stimulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. Evidence for protein kinase C-dependent and Ca2+/calmodulin-dependent pathways. Homma T, Burns KD, Harris RC (1990) J Biol Chem 265(29): 17613-20
    › Primary publication · 2170389 (PubMed)
  225. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. Harris RC, Homma T, Jacobson HR, Capdevila J (1990) J Cell Physiol 144(3): 429-37
    › Primary publication · 2167900 (PubMed)
  226. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. Kon V, Harris RC, Ichikawa I (1990) J Clin Invest 85(6): 1728-33
    › Primary publication · 2140836 (PubMed) · PMC296633 (PubMed Central)
  227. Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. Harris RC, Munger KA, Badr KF, Takahashi K (1990) FASEB J 4(6): 1654-60
    › Primary publication · 2138579 (PubMed)
  228. Recovery of prostaglandin synthesis in rat glomerular mesangial cells after aspirin inhibition: induction of cyclooxygenase activity by serum and epidermal growth factor. Harris RC, Badr KF (1990) Prostaglandins 39(2): 213-22
    › Primary publication · 2107566 (PubMed)
  229. Potential physiologic roles for epidermal growth factor in the kidney. Harris RC (1991) Am J Kidney Dis 17(6): 627-30
    › Primary publication · 2042635 (PubMed)
  230. Time-dependent biphasic regulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. Homma T, Harris RC (1991) J Biol Chem 266(21): 13553-9
    › Primary publication · 1856192 (PubMed)
  231. Angiotensin actions in the kidney: renewed insight into the old hormone. Ichikawi I, Harris RC (1991) Kidney Int 40(4): 583-96
    › Primary publication · 1745006 (PubMed)
  232. Cytosolic acidification stimulates a calcium influx that activates Na(+)-H+ exchange in LLC-PK1. Burns KD, Homma T, Breyer MD, Harris RC (1991) Am J Physiol 261(4 Pt 2): F617-25
    › Primary publication · 1656781 (PubMed)
  233. Regulation of Na(+)-H+ exchange by ATP depletion and calmodulin antagonism in renal epithelial cells. Burns KD, Homma T, Harris RC (1991) Am J Physiol 261(4 Pt 2): F607-16
    › Primary publication · 1656780 (PubMed)
  234. Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Awazu M, Kon V, Harris RC, Imada T, Inagami T, Ichikawa I (1991) Am J Physiol 261(1 Pt 2): F29-35
    › Primary publication · 1650144 (PubMed)
  235. Regulation of S6 kinase activity in renal proximal tubule. Harris RC (1992) Am J Physiol 263(1 Pt 2): F127-34
    › Primary publication · 1636737 (PubMed)
  236. Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Harris RC, Haralson MA, Badr KF (1992) Lab Invest 66(5): 548-54
    › Primary publication · 1573850 (PubMed)
  237. Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia. McKanna JA, Chuncharunee A, Munger KA, Breyer JA, Cohen S, Harris RC (1992) J Cell Physiol 153(3): 467-76
    › Primary publication · 1447309 (PubMed)
  238. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. Homma T, Akai Y, Burns KD, Harris RC (1992) J Biol Chem 267(32): 23129-35
    › Primary publication · 1429660 (PubMed)