Charles Ellis
Last active: 9/24/2018


Dr. Charles D. Ellis is currently a Research Instructor at the Vanderbilt University School of Medicine in Nashville, Tennessee.  Dr. Ellis received his doctorate in Inorganic Chemistry from the University of North Carolina at Chapel Hill, and began his career at E. I. du Pont de Nemours & Co., where he received a US Patent for medical X-ray film technology.  He started his academic career at Vanderbilt in the Center for Structural Biology, where he performed research on the expression and structural determination of membrane proteins.  He co-authored a paper that describes the NMR structure determination of an integral membrane protein enzyme, diacylglycerol kinase, a 100-kDa protein-detergent complex, which was published in Science.  Dr. Ellis has since joined the Division of Nephrology where he manages all facets of the clinical, translational and epidemiological research activities for a number of senior and junior faculty.  His areas of expertise include (1) regulatory (Institutional Review Boards, Data Safety Monitoring Boards, listings); (2) financial (budget development and analysis, Billing Plan/FACTr submissions, billing/invoicing, contracts); (3) database creation and management (both REDCap and Access-based); (4) data and trial coordination (Investigational Drug Services, Data Coordinating Centers, equipment, personnel); and (5) operational (standard operating procedures, sample collection/processing/analysis).


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Insulin resistance is a significant determinant of sarcopenia in advanced kidney disease. Deger SM, Hewlett JR, Gamboa J, Ellis CD, Hung AM, Siew ED, Mamnungu C, Sha F, Bian A, Stewart TG, Abumrad NN, Ikizler TA (2018) Am J Physiol Endocrinol Metab 315(6): E1108-E1120
    › Primary publication · 29894202 (PubMed) · PMC6336962 (PubMed Central)
  2. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA (2017) JCI Insight 2(22)
    › Primary publication · 29202452 (PubMed) · PMC5752392 (PubMed Central)
  3. Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial. Ikizler TA, Robinson-Cohen C, Ellis C, Headley SAE, Tuttle K, Wood RJ, Evans EE, Milch CM, Moody KA, Germain M, Limkunakul C, Bian A, Stewart TG, Himmelfarb J (2018) J Am Soc Nephrol 29(1): 250-259
    › Primary publication · 29038285 (PubMed) · PMC5748901 (PubMed Central)
  4. Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients. Deger SM, Wang P, Fissell R, Ellis CD, Booker C, Sha F, Morse JL, Stewart TG, Gore JC, Siew ED, Titze J, Ikizler TA (2017) J Cachexia Sarcopenia Muscle 8(3): 500-507
    › Primary publication · 28150400 (PubMed) · PMC5476848 (PubMed Central)
  5. Leucine disposal rate for assessment of amino acid metabolism in maintenance hemodialysis patients. Denny GB, Deger SM, Chen G, Bian A, Sha F, Booker C, Kesler JT, David S, Ellis CD, Ikizler TA (2016) BMC Nutr
    › Primary publication · 27413537 (PubMed) · PMC4939826 (PubMed Central)
  6. High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Deger SM, Hung AM, Ellis CD, Booker C, Bian A, Chen G, Abumrad NN, Ikizler TA (2016) Clin J Am Soc Nephrol 11(7): 1227-35
    › Primary publication · 27281699 (PubMed) · PMC4934832 (PubMed Central)
  7. Measurement and Correlation of Indices of Insulin Resistance in Patients on Peritoneal Dialysis. King-Morris KR, Deger SM, Hung AM, Egbert PA, Ellis CD, Graves A, Shintani A, Ikizler TA (2016) Perit Dial Int 36(4): 433-41
    › Primary publication · 26526047 (PubMed) · PMC4853288 (PubMed Central)
  8. Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients. Rivara MB, Ikizler TA, Ellis CD, Mehrotra R, Himmelfarb J (2015) BMC Nephrol : 79
    › Primary publication · 26045064 (PubMed) · PMC4455324 (PubMed Central)
  9. Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA (2015) Nephrol Dial Transplant 30(2): 266-74
    › Primary publication · 25204316 (PubMed) · PMC4309191 (PubMed Central)
  10. Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. Hung AM, Limkunakul C, Placido JS, Siew ED, Ellis CD, Shintani A, Ikizler TA (2014) J Nephrol 27(6): 681-8
    › Primary publication · 24609887 (PubMed)
  11. Obesity, diabetes and survival in maintenance hemodialysis patients. Deger SM, Ellis CD, Bian A, Shintani A, Ikizler TA, Hung AM (2014) Ren Fail 36(4): 546-51
    › Primary publication · 24467439 (PubMed) · PMC4976601 (PubMed Central)
  12. Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial. Himmelfarb J, Ikizler TA, Ellis C, Wu P, Shintani A, Dalal S, Kaplan M, Chonchol M, Hakim RM (2014) J Am Soc Nephrol 25(3): 623-33
    › Primary publication · 24371300 (PubMed) · PMC3935590 (PubMed Central)
  13. Insulin resistance and protein metabolism in chronic hemodialysis patients. Deger SM, Sundell MB, Siew ED, Egbert P, Ellis CD, Sha F, Ikizler TA, Hung AM (2013) J Ren Nutr 23(3): e59-66
    › Primary publication · 23194840 (PubMed) · PMC3852904 (PubMed Central)
  14. A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis. Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA (2013) J Ren Nutr 23(3): 185-93
    › Primary publication · 22959781 (PubMed) · PMC3519966 (PubMed Central)
  15. A comparison of novel and commonly-used indices of insulin sensitivity in African American chronic hemodialysis patients. Hung AM, Sundell MB, Egbert P, Siew ED, Shintani A, Ellis CD, Bian A, Ikizler TA (2011) Clin J Am Soc Nephrol 6(4): 767-74
    › Primary publication · 21441124 (PubMed) · PMC3069368 (PubMed Central)
  16. IL-1β receptor antagonist reduces inflammation in hemodialysis patients. Hung AM, Ellis CD, Shintani A, Booker C, Ikizler TA (2011) J Am Soc Nephrol 22(3): 437-42
    › Primary publication · 21310819 (PubMed) · PMC3060437 (PubMed Central)
  17. Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids. Koehler J, Sulistijo ES, Sakakura M, Kim HJ, Ellis CD, Sanders CR (2010) Biochemistry 49(33): 7089-99
    › Primary publication · 20666483 (PubMed) · PMC2923640 (PubMed Central)
  18. Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sönnichsen FD, Sanders CR (2009) Science 324(5935): 1726-9
    › Primary publication · 19556511 (PubMed) · PMC2764269 (PubMed Central)
  19. Purification and initiation of structural characterization of human peripheral myelin protein 22, an integral membrane protein linked to peripheral neuropathies. Mobley CK, Myers JK, Hadziselimovic A, Ellis CD, Sanders CR (2007) Biochemistry 46(39): 11185-95
    › Primary publication · 17824619 (PubMed)
  20. Membrane protein preparation for TROSY NMR screening. Tian C, Karra MD, Ellis CD, Jacob J, Oxenoid K, Sönnichsen F, Sanders CR (2005) Methods Enzymol : 321-34
    › Primary publication · 15808226 (PubMed)
  21. French swimwear for membrane proteins. Sanders CR, Kuhn Hoffmann A, Gray DN, Keyes MH, Ellis CD (2004) Chembiochem 5(4): 423-6
    › Primary publication · 15185363 (PubMed)

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    Contact Information

    1161 21st Avenue South
    S-3223 Medical Center North
    Nashville, TN 37232-2372
    615-343-8296 (p)
    615-343-7156 (f)

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Adiponectin Adiposity Albuminuria Body Mass Index Body Weight Calcitonin Gene-Related Peptide Chemokines Chronic Disease Circular Dichroism Disease Models, Animal Drug Resistance Escherichia coli Proteins Glucose Clamp Technique Humans Integrin beta1 Mice Micelles Muscle, Skeletal Myelin Proteins Naphthalenes Organ Specificity Oxidative Stress Peritoneal Dialysis Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Skin Tennessee Up-Regulation Vitamin D Deficiency