Paul Bock
Last active: 1/20/2015


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The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Full time course kinetics of the streptokinase-plasminogen activation pathway. Nolan M, Bouldin SD, Bock PE (2013) J Biol Chem 288(41): 29482-93
    › Primary publication · 23970549 (PubMed) · PMC3795247 (PubMed Central)
  2. Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein. Kroh HK, Bock PE (2012) J Biol Chem 287(46): 39149-57
    › Primary publication · 23012355 (PubMed) · PMC3493955 (PubMed Central)
  3. Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Tormoen GW, Cianchetti FA, Bock PE, McCarty OJ (2012) Front Oncol : 110
    › Primary publication · 22973554 (PubMed) · PMC3434442 (PubMed Central)
  4. Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes. Newell-Caito JL, Laha M, Tharp AC, Creamer JI, Xu H, Maddur AA, Tans G, Bock PE (2011) J Biol Chem 286(44): 38286-38297
    › Primary publication · 21911491 (PubMed) · PMC3207456 (PubMed Central)
  5. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R (2011) Nat Med 17(9): 1142-6
    › Primary publication · 21857652 (PubMed) · PMC3169740 (PubMed Central)
  6. Engineering streptokinase for generation of active site-labeled plasminogen analogs. Laha M, Panizzi P, Nahrendorf M, Bock PE (2011) Anal Biochem 415(2): 105-15
    › Primary publication · 21570944 (PubMed) · PMC3114107 (PubMed Central)
  7. Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction. Corral-Rodríguez MÁ, Bock PE, Hernández-Carvajal E, Gutiérrez-Gallego R, Fuentes-Prior P (2011) Blood 117(26): 7164-73
    › Primary publication · 21555742 (PubMed) · PMC3143557 (PubMed Central)
  8. Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo. Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE (2011) J Biol Chem 286(26): 23345-56
    › Primary publication · 21531712 (PubMed) · PMC3123099 (PubMed Central)
  9. Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells. Berny-Lang MA, Aslan JE, Tormoen GW, Patel IA, Bock PE, Gruber A, McCarty OJ (2011) Phys Biol 8(1): 015014
    › Primary publication · 21301066 (PubMed) · PMC3209705 (PubMed Central)
  10. Inhibition of thrombin formation by active site mutated (S360A) activated protein C. Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J (2010) J Biol Chem 285(30): 22890-900
    › Primary publication · 20484050 (PubMed) · PMC2906281 (PubMed Central)
  11. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. Berny MA, Munnix IC, Auger JM, Schols SE, Cosemans JM, Panizzi P, Bock PE, Watson SP, McCarty OJ, Heemskerk JW (2010) PLoS One 5(4): e10415
    › Primary publication · 20454680 (PubMed) · PMC2861630 (PubMed Central)
  12. Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation. Wiles KG, Panizzi P, Kroh HK, Bock PE (2010) J Biol Chem 285(27): 21153-64
    › Primary publication · 20435890 (PubMed) · PMC2898333 (PubMed Central)
  13. Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate. Tharp AC, Laha M, Panizzi P, Thompson MW, Fuentes-Prior P, Bock PE (2009) J Biol Chem 284(29): 19511-21
    › Primary publication · 19473980 (PubMed) · PMC2740577 (PubMed Central)
  14. Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin. Kroh HK, Panizzi P, Bock PE (2009) Proc Natl Acad Sci U S A 106(19): 7786-91
    › Primary publication · 19416890 (PubMed) · PMC2683071 (PubMed Central)
  15. Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation. Verhamme IM, Bock PE (2008) J Biol Chem 283(38): 26137-47
    › Primary publication · 18658146 (PubMed) · PMC2533780 (PubMed Central)
  16. Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation. Smith SB, Verhamme IM, Sun MF, Bock PE, Gailani D (2008) J Biol Chem 283(11): 6696-705
    › Primary publication · 18192270 (PubMed) · PMC2633474 (PubMed Central)
  17. The role of thrombin exosites I and II in the activation of human coagulation factor V. Segers K, Dahlbäck B, Bock PE, Tans G, Rosing J, Nicolaes GA (2007) J Biol Chem 282(47): 33915-24
    › Primary publication · 17878169 (PubMed) · PMC2292461 (PubMed Central)
  18. Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase. Hacisalihoglu A, Panizzi P, Bock PE, Camire RM, Krishnaswamy S (2007) J Biol Chem 282(45): 32974-82
    › Primary publication · 17848548 (PubMed) · PMC2292459 (PubMed Central)
  19. A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids. Henry BL, Monien BH, Bock PE, Desai UR (2007) J Biol Chem 282(44): 31891-9
    › Primary publication · 17804413 (PubMed) · PMC2643123 (PubMed Central)
  20. Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Munnix IC, Kuijpers MJ, Auger J, Thomassen CM, Panizzi P, van Zandvoort MA, Rosing J, Bock PE, Watson SP, Heemskerk JW (2007) Arterioscler Thromb Vasc Biol 27(11): 2484-90
    › Primary publication · 17761939 (PubMed) · PMC2376762 (PubMed Central)
  21. Exosites in the substrate specificity of blood coagulation reactions. Bock PE, Panizzi P, Verhamme IM (2007) J Thromb Haemost : 81-94
    › Primary publication · 17635714 (PubMed) · PMC2291348 (PubMed Central)
  22. Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation. Kroh HK, Tans G, Nicolaes GA, Rosing J, Bock PE (2007) J Biol Chem 282(22): 16095-104
    › Primary publication · 17430903 (PubMed) · PMC2292469 (PubMed Central)
  23. Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes. Panizzi P, Boxrud PD, Verhamme IM, Bock PE (2006) J Biol Chem 281(37): 26774-8
    › Primary publication · 16857686 (PubMed) · PMC2291350 (PubMed Central)
  24. Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions. Panizzi P, Friedrich R, Fuentes-Prior P, Kroh HK, Briggs J, Tans G, Bode W, Bock PE (2006) J Biol Chem 281(2): 1169-78
    › Primary publication · 16230340 (PubMed) · PMC2292460 (PubMed Central)
  25. Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes. Panizzi P, Friedrich R, Fuentes-Prior P, Richter K, Bock PE, Bode W (2006) J Biol Chem 281(2): 1179-87
    › Primary publication · 16230339 (PubMed) · PMC2291351 (PubMed Central)
  26. Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation. Friedrich R, Panizzi P, Kawabata S, Bode W, Bock PE, Fuentes-Prior P (2006) J Biol Chem 281(2): 1188-95
    › Primary publication · 16230338 (PubMed) · PMC2292465 (PubMed Central)
  27. Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase. Bianchini EP, Orcutt SJ, Panizzi P, Bock PE, Krishnaswamy S (2005) Proc Natl Acad Sci U S A 102(29): 10099-104
    › Primary publication · 16006504 (PubMed) · PMC1174926 (PubMed Central)
  28. Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX. Ogawa T, Verhamme IM, Sun MF, Bock PE, Gailani D (2005) J Biol Chem 280(25): 23523-30
    › Primary publication · 15829482 (PubMed) · PMC2292466 (PubMed Central)
  29. Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin. Bean RR, Verhamme IM, Bock PE (2005) J Biol Chem 280(9): 7504-10
    › Primary publication · 15623524 (PubMed) · PMC2292463 (PubMed Central)
  30. The staphylocoagulase family of zymogen activator and adhesion proteins. Panizzi P, Friedrich R, Fuentes-Prior P, Bode W, Bock PE (2004) Cell Mol Life Sci 61(22): 2793-8
    › Primary publication · 15558209 (PubMed) · PMC2291352 (PubMed Central)
  31. Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase. Boxrud PD, Verhamme IM, Bock PE (2004) J Biol Chem 279(35): 36633-41
    › Primary publication · 15215240 (PubMed)
  32. Coupling of conformational and proteolytic activation in the kinetic mechanism of plasminogen activation by streptokinase. Boxrud PD, Bock PE (2004) J Biol Chem 279(35): 36642-9
    › Primary publication · 15215239 (PubMed)
  33. The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II. Verhamme IM, Bock PE, Jackson CM (2004) J Biol Chem 279(11): 9785-95
    › Primary publication · 14701814 (PubMed)
  34. Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I, Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE (2003) Nature 425(6957): 535-9
    › Primary publication · 14523451 (PubMed)
  35. Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin. Anderson PJ, Bock PE (2003) J Biol Chem 278(45): 44489-95
    › Primary publication · 12939270 (PubMed)
  36. Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin. Anderson PJ, Nesset A, Bock PE (2003) J Biol Chem 278(45): 44482-8
    › Primary publication · 12939269 (PubMed)
  37. Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites. Bedsted T, Swanson R, Chuang YJ, Bock PE, Björk I, Olson ST (2003) Biochemistry 42(27): 8143-52
    › Primary publication · 12846563 (PubMed)
  38. Structure, function, and regulation of free and membrane-bound ribosomes: the view from their substrates and products. Johnson AE, Chen JC, Flanagan JJ, Miao Y, Shao Y, Lin J, Bock PE (2001) Cold Spring Harb Symp Quant Biol : 531-41
    › Primary publication · 12762055 (PubMed)
  39. Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. Flanagan JJ, Chen JC, Miao Y, Shao Y, Lin J, Bock PE, Johnson AE (2003) J Biol Chem 278(20): 18628-37
    › Primary publication · 12621052 (PubMed)
  40. Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II. Verhamme IM, Olson ST, Tollefsen DM, Bock PE (2002) J Biol Chem 277(9): 6788-98
    › Primary publication · 11724802 (PubMed)
  41. Biotin derivatives of D-Phe-Pro-Arg-CH2Cl for active-site-specific labeling of thrombin and other serine proteinases. Anderson PJ, Bock PE (2001) Anal Biochem 296(2): 254-61
    › Primary publication · 11554721 (PubMed)
  42. Characterization of bothrojaracin interaction with human prothrombin. Monteiro RQ, Bock PE, Bianconi ML, Zingali RB (2001) Protein Sci 10(9): 1897-904
    › Primary publication · 11514680 (PubMed) · PMC2253206 (PubMed Central)
  43. Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation. Boxrud PD, Verhamme IM, Fay WP, Bock PE (2001) J Biol Chem 276(28): 26084-9
    › Primary publication · 11369771 (PubMed)
  44. Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A. Pekovich SR, Bock PE, Hoover RL (2001) FEBS Lett 494(1-2): 129-32
    › Primary publication · 11297749 (PubMed)
  45. Streptokinase binds preferentially to the extended conformation of plasminogen through lysine binding site and catalytic domain interactions. Boxrud PD, Bock PE (2000) Biochemistry 39(45): 13974-81
    › Primary publication · 11076540 (PubMed)
  46. Streptokinase binds to human plasmin with high affinity, perturbs the plasmin active site, and induces expression of a substrate recognition exosite for plasminogen. Boxrud PD, Fay WP, Bock PE (2000) J Biol Chem 275(19): 14579-89
    › Primary publication · 10799544 (PubMed)
  47. Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation. Anderson PJ, Nesset A, Dharmawardana KR, Bock PE (2000) J Biol Chem 275(22): 16435-42
    › Primary publication · 10748008 (PubMed)
  48. Characterization of proexosite I on prothrombin. Anderson PJ, Nesset A, Dharmawardana KR, Bock PE (2000) J Biol Chem 275(22): 16428-34
    › Primary publication · 10748007 (PubMed)
  49. Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments. Dharmawardana KR, Olson ST, Bock PE (1999) J Biol Chem 274(26): 18635-43
    › Primary publication · 10373475 (PubMed)
  50. Allosteric effects of a monoclonal antibody against thrombin exosite II Colwell NS, Blinder MA, Tsiang M, Gibbs CS, Bock PE, Tollefsen DM (1999) Biochemistry 38(8): 2610
    › Primary publication · 10029715 (PubMed)
  51. Allosteric effects of a monoclonal antibody against thrombin exosite II. Colwell NS, Blinder MA, Tsiang M, Gibbs CS, Bock PE, Tollefsen DM (1998) Biochemistry 37(43): 15057-65
    › Primary publication · 9790668 (PubMed)
  52. Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine proteinases. Dharmawardana KR, Bock PE (1998) Biochemistry 37(38): 13143-52
    › Primary publication · 9748321 (PubMed)
  53. Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I. Bock PE, Olson ST, Björk I (1997) J Biol Chem 272(32): 19837-45
    › Primary publication · 9242645 (PubMed)
  54. Modulation of thrombin and heparin activities by fibrin. Hogg PJ, Bock PE (1997) Thromb Haemost 77(3): 424-33
    › Primary publication · 9065987 (PubMed)
  55. Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen. Hogg PJ, Jackson CM, Labanowski JK, Bock PE (1996) J Biol Chem 271(42): 26088-95
    › Primary publication · 8824251 (PubMed)
  56. Analogs of human plasminogen that are labeled with fluorescence probes at the catalytic site of the zymogen. Preparation, characterization, and interaction with streptokinase. Bock PE, Day DE, Verhamme IM, Bernardo MM, Olson ST, Shore JD (1996) J Biol Chem 271(2): 1072-80
    › Primary publication · 8557633 (PubMed)
  57. Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes. Olson ST, Bock PE, Kvassman J, Shore JD, Lawrence DA, Ginsburg D, Björk I (1995) J Biol Chem 270(50): 30007-17
    › Primary publication · 8530403 (PubMed)
  58. Kinetic characterization of the proteinase binding defect in a reactive site variant of the serpin, antithrombin. Role of the P1' residue in transition-state stabilization of antithrombin-proteinase complex formation. Olson ST, Stephens AW, Hirs CH, Bock PE, Björk I (1995) J Biol Chem 270(17): 9717-24
    › Primary publication · 7730349 (PubMed)
  59. The multiple complexes formed by the interaction of platelet factor 4 with heparin. Bock PE, Luscombe M, Marshall SE, Pepper DS, Holbrook JJ (1980) Biochem J 191(3): 769-76
    › Primary publication · 7283972 (PubMed) · PMC1162276 (PubMed Central)
  60. Activation of intrinsic blood coagulation by ellagic acid: insoluble ellagic acid-metal ion complexes are the activating species. Bock PE, Srinivasan KR, Shore JD (1981) Biochemistry 20(25): 7258-66
    › Primary publication · 6797471 (PubMed)
  61. Molecular weight of human high-molecular-weight kininogen light chain by equilibrium sedimentation in an air-driven ultracentrifuge. Bock PE, Halvorson HR (1983) Anal Biochem 135(1): 172-9
    › Primary publication · 6670737 (PubMed)
  62. Protein-protein interactions in contact activation of blood coagulation. Characterization of fluorescein-labeled human high molecular weight kininogen-light chain as a probe. Bock PE, Shore JD (1983) J Biol Chem 258(24): 15079-86
    › Primary publication · 6558074 (PubMed)
  63. The effect of concentration and ionic strength on the aggregation of beta-thromboglobulin. Bock PE, Luscombe M, Marshall SE, Pepper DS, Holbrook JJ (1982) Thromb Res 25(1-2): 169-72
    › Primary publication · 6175042 (PubMed)
  64. pH-induced cold lability of rabbit skeletal muscle phosphofructokinase. Bock PE, Frieden C (1974) Biochemistry 13(20): 4191-6
    › Primary publication · 4277765 (PubMed)
  65. Protein-protein interactions in contact activation of blood coagulation. Binding of high molecular weight kininogen and the 5-(iodoacetamido) fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light chains. Bock PE, Shore JD, Tans G, Griffin JH (1985) J Biol Chem 260(23): 12434-43
    › Primary publication · 3850090 (PubMed)
  66. Active site selective labeling of serine proteases with spectroscopic probes using thioester peptide chloromethyl ketones: demonstration of thrombin labeling using N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl. Bock PE (1988) Biochemistry 27(17): 6633-9
    › Primary publication · 3219359 (PubMed)
  67. Acceleration of surface-dependent autocatalytic activation of blood coagulation factor XII by divalent metal ions. Shore JD, Day DE, Bock PE, Olson ST (1987) Biochemistry 26(8): 2250-8
    › Primary publication · 3113477 (PubMed)
  68. Isolation of human blood coagulation alpha-factor Xa by soybean trypsin inhibitor-sepharose chromatography and its active-site titration with fluorescein mono-p-guanidinobenzoate. Bock PE, Craig PA, Olson ST, Singh P (1989) Arch Biochem Biophys 273(2): 375-88
    › Primary publication · 2774557 (PubMed)
  69. Kinetic intermediates in prothrombin activation. Bovine prethrombin 1 conversion to thrombin by factor X. Carlisle TL, Bock PE, Jackson CM (1990) J Biol Chem 265(35): 22044-55
    › Primary publication · 2254347 (PubMed)
  70. Quantitative evaluation of solution equilibrium binding interactions by affinity partitioning: application to specific and nonspecific protein-heparin interactions. Olson ST, Bock PE, Sheffer R (1991) Arch Biochem Biophys 286(2): 533-45
    › Primary publication · 1897976 (PubMed)
  71. Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor. Björk I, Ylinenjärvi K, Olson ST, Bock PE (1992) J Biol Chem 267(3): 1976-82
    › Primary publication · 1730729 (PubMed)
  72. Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. II. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of the labeling approach for other proteinases. Bock PE (1992) J Biol Chem 267(21): 14974-81
    › Primary publication · 1634536 (PubMed)
  73. Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. I. Specificity of thrombin labeling. Bock PE (1992) J Biol Chem 267(21): 14963-73
    › Primary publication · 1634535 (PubMed)
  74. Factor XIII: a study using polarization of fluorescence of the activation of the enzyme by calcium and by substrate [proceedings]. Holbrook JJ, Lewis BA, Freyssinet JM, Bock PE, Shore JD (1977) Biochem Soc Trans 5(5): 1247-51
    › Primary publication · 923904 (PubMed)
  75. Analysis of the cold lability behavior of rabbit muscle phosphofructokinase. Bock PE, Gilbert HR, Frieden C (1975) Biochem Biophys Res Commun 66(2): 564-9
    › Primary publication · 241341 (PubMed)
  76. Calcium and the assembly of human blood-clotting factor XIII. Bock PE, Beavis AD, Holbrook JJ (1979) Biochem Soc Trans 7(4): 627-8
    › Primary publication · 113264 (PubMed)
  77. Phosphofructokinase. III. Correlation of the regulatory kinetic and molecular properties of the rabbit muscle enzyme. Frieden C, Gilbert HR, Bock PE (1976) J Biol Chem 251(18): 5644-7
    › Primary publication · 9395 (PubMed)
  78. Phosphofructokinase. II. Role of ligands in pH-dependent structural changes of the rabbit muscle enzyme. Bock PE, Frieden C (1976) J Biol Chem 251(18): 5637-43
    › Primary publication · 9394 (PubMed)
  79. Phosphofructokinase. I. Mechanism of the pH-dependent inactivation and reactivation of the rabbit muscle enzyme. Bock PE, Frieden C (1976) J Biol Chem 251(18): 5630-6
    › Primary publication · 9393 (PubMed)