Nagaraj Nagathihalli
Last active: 12/19/2014

Profile

Academic Positions:

Research Assistant Professor of Surgery, Vanderbilt University School of Medicine (2011-present)

Research Assistant Professor of Cancer Biology, Vanderbilt University School of Medicine (2012-present)

Member, Vanderbilt-Ingram Comprehensive Cancer Center (2011-present)

Research Instructor of Surgery, Vanderbilt University School of Medicine (2007-2011)

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB (2014) Cancer Res 74(7): 2062-72
    › Primary publication · 24520077 (PubMed) · PMC3975694 (PubMed Central)
  2. Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells. Castellanos JA, Merchant NB, Nagathihalli NS (2013) Onco Targets Ther : 1261-7
    › Primary publication · 24049451 (PubMed) · PMC3775701 (PubMed Central)
  3. Integrating genomics and proteomics-oriented biomarkers to comprehend lung cancer. Nagaraj NS, Singh OV (2009) Expert Opin Med Diagn 3(2): 167-80
    › Primary publication · 23485163 (PubMed)
  4. Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin. Nagathihalli NS, Massion PP, Gonzalez AL, Lu P, Datta PK (2012) Mol Cancer Ther 11(11): 2362-72
    › Primary publication · 22933707 (PubMed) · PMC3969334 (PubMed Central)
  5. Src-mediated regulation of E-cadherin and EMT in pancreatic cancer. Nagathihalli NS, Merchant NB (2012) Front Biosci (Landmark Ed) : 2059-69
    › Primary publication · 22652764 (PubMed)
  6. Translational research in gastrointestinal oncology: a focus on signaling pathways in pancreas cancer. Nagathihalli N (2011) Gastrointest Cancer Res 4(5-6): 197-8
    › Primary publication · 22295136 (PubMed) · PMC3269147 (PubMed Central)
  7. Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer. Samanta D, Gonzalez AL, Nagathihalli N, Ye F, Carbone DP, Datta PK (2012) Cancer Prev Res (Phila) 5(3): 453-63
    › Primary publication · 22232600 (PubMed) · PMC4299594 (PubMed Central)
  8. RAD51 as a potential biomarker and therapeutic target for pancreatic cancer. Nagathihalli NS, Nagaraju G (2011) Biochim Biophys Acta 1816(2): 209-18
    › Primary publication · 21807066 (PubMed)
  9. Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. Nagaraj NS, Washington MK, Merchant NB (2011) Clin Cancer Res 17(3): 483-93
    › Primary publication · 21266529 (PubMed) · PMC3079196 (PubMed Central)
  10. Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Nagaraj NS, Smith JJ, Revetta F, Washington MK, Merchant NB (2010) Mol Cancer Ther 9(8): 2322-32
    › Primary publication · 20682659 (PubMed) · PMC3449211 (PubMed Central)
  11. Using genomics to develop novel antibacterial therapeutics. Nagaraj NS, Singh OV (2010) Crit Rev Microbiol 36(4): 340-8
    › Primary publication · 20670176 (PubMed)
  12. Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy. Nagaraj NS, Singh OV, Merchant NB (2010) Expert Rev Proteomics 7(4): 613-23
    › Primary publication · 20653514 (PubMed) · PMC4339030 (PubMed Central)
  13. Targeting the transforming growth factor-beta signaling pathway in human cancer. Nagaraj NS, Datta PK (2010) Expert Opin Investig Drugs 19(1): 77-91
    › Primary publication · 20001556 (PubMed) · PMC2796203 (PubMed Central)
  14. Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway. Nagaraj NS, Anilakumar KR, Singh OV (2010) J Nutr Biochem 21(5): 405-12
    › Primary publication · 19423321 (PubMed)
  15. Evolving 'omics' technologies for diagnostics of head and neck cancer. Nagaraj NS (2009) Brief Funct Genomic Proteomic 8(1): 49-59
    › Primary publication · 19273537 (PubMed)
  16. Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn. Anilakumar KR, Nagaraj NS, Santhanam K (2007) Indian J Exp Biol 45(5): 450-4
    › Primary publication · 17569287 (PubMed)
  17. Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells. Nagaraj NS, Zacharias W (2007) Toxicol Lett 170(2): 134-45
    › Primary publication · 17399918 (PubMed) · PMC1952681 (PubMed Central)
  18. Transcriptomics, proteomics and interactomics: unique approaches to track the insights of bioremediation. Singh OV, Nagaraj NS (2006) Brief Funct Genomic Proteomic 4(4): 355-62
    › Primary publication · 17202126 (PubMed)
  19. Hypoxia inhibits TRAIL-induced tumor cell apoptosis: involvement of lysosomal cathepsins. Nagaraj NS, Vigneswaran N, Zacharias W (2007) Apoptosis 12(1): 125-39
    › Primary publication · 17136492 (PubMed) · PMC5774619 (PubMed Central)
  20. Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells. Nagaraj NS, Beckers S, Mensah JK, Waigel S, Vigneswaran N, Zacharias W (2006) Toxicol Lett 165(2): 182-94
    › Primary publication · 16713138 (PubMed) · PMC5774676 (PubMed Central)
  21. Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells. Nagaraj NS, Vigneswaran N, Zacharias W (2006) J Cancer Res Clin Oncol 132(3): 171-83
    › Primary publication · 16362335 (PubMed) · PMC5774671 (PubMed Central)
  22. Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines. Wickramasinghe NS, Banerjee K, Nagaraj NS, Vigneswaran N, Zacharias W (2005) Anticancer Res 25(4): 2841-9
    › Primary publication · 16080536 (PubMed)
  23. Cathepsin B promotes both motility and invasiveness of oral carcinoma cells. Wickramasinghe NS, Nagaraj NS, Vigneswaran N, Zacharias W (2005) Arch Biochem Biophys 436(1): 187-95
    › Primary publication · 15752724 (PubMed)