Profile

 

Our laboratory has established two major lines of research.

 

To study the molecular mechanisms of kidney fibrosis, focusing on cell-matrix interactions and arachidonic acid-derived eicosanoids in kidney injury. 

 

Cell-matrix interaction in kidney homeostasis:  As progressive accumulation of extracellular matrix (ECM), mainly collagens, leads to fibrosis, our goal is to determine how interactions between ECM and cells via specific ECM receptors control ECM synthesis/remodeling in health and disease. Among the collagen receptors, we study integrins and discodin domain receptors (DDRs).  We have identified integrin α1β1 as an anti-fibrotic integrin whose activation leads to downregulation of endogenous collagen synthesis and negatively modulates fibrosis. Recently, we have identified integrin α2β1 and DDR1 as a positive regulator of kidney fibrosis and provide evidence that mice lacking these receptors are protected from fibrosis following injury. Finally, we study how these matrix receptors crosstalk with pro-fibrotic growth factor receptors, including EGF and TGF-b receptors.

 

Arachidonic acid-derived eicosanoids in kidney homeostasis:  The P450 arachidonic acid monooxygenases oxidize arachidonic acid to a) 19- or 20-HETE (w-hydroxylase or CYP4 isoforms), or b) 5,6-, 8,9-, 11,12-, or 14,15-EET (epoxygenase or CYP2 isoforms).  Both EETs and HETEs have markedly divergent biological effects depending on the tissue of origin.  For example, 20-HETE causes vasoconstriction and promotes hypertension, while EETs are vasodilators and lower blood pressure.  As hypertension and kidney injury are frequently associated, a goal of our research is to determine the relative contribution of EETs vs. HETE to kidney homeostasis by using mice lacking and/or overexpressing key enzymes involved in the synthesis of EETs and/or HETEs.  Using these in vivo tools we intend to test the hypothesis that EETs protects from, while 20-HETEs contributes to kidney injury.

 

 

 

To study the molecular mechanisms controlling endothelial cell functions in order to devise valid and better tolerated anti-angiogenic therapy. 

 

In the past 10 years our laboratory has investigated the role of cell-matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and/or down-regulation is beneficial in the setting of tumor associated angiogenesis. More recently, we have started to investigate the role of arachidonic acid P450 epoxygenases in the control of endothelial cell function in vitro and tumorigenesis in vivo.  We provide evidence that the products of P450 epoxygenases are pro-angiogenic in vivo and in vitro and maneuvers to prevent their synthesis plays a beneficial effect in slowing cancer progression in vivo.

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance. Williams AS, Kang L, Zheng J, Grueter C, Bracy DP, James FD, Pozzi A, Wasserman DH (2015) J Biol Chem 290(10): 6546-57
    › Primary publication · 25593319 (PubMed) · PMC4358288 (PubMed Central)
  2. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A (2015) Kidney Int 87(5): 948-62
    › Primary publication · 25565313 (PubMed) · PMC4425591 (PubMed Central)
  3. Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Kothiwale S, Borza CM, Lowe EW, Pozzi A, Meiler J (2015) Drug Discov Today 20(2): 255-61
    › Primary publication · 25284748 (PubMed) · PMC4336622 (PubMed Central)
  4. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A (2015) J Am Soc Nephrol 26(3): 597-610
    › Primary publication · 25071086 (PubMed) · PMC4341468 (PubMed Central)
  5. Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A (2014) J Clin Invest 124(8): 3295-310
    › Primary publication · 24983314 (PubMed) · PMC4109532 (PubMed Central)
  6. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Miller CG, Pozzi A, Zent R, Schwarzbauer JE (2014) Mol Biol Cell 25(16): 2342-50
    › Primary publication · 24943838 (PubMed) · PMC4142608 (PubMed Central)
  7. Techniques and assays for the study of angiogenesis. Irvin MW, Zijlstra A, Wikswo JP, Pozzi A (2014) Exp Biol Med (Maywood) 239(11): 1476-88
    › Primary publication · 24872440 (PubMed) · PMC4216737 (PubMed Central)
  8. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC (2014) Development 141(7): 1480-91
    › Primary publication · 24574008 (PubMed) · PMC3957372 (PubMed Central)
  9. The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R (2014) J Biol Chem 289(12): 8532-44
    › Primary publication · 24509849 (PubMed) · PMC3961677 (PubMed Central)
  10. Integrin α1β1 participates in chondrocyte transduction of osmotic stress. Jablonski CL, Ferguson S, Pozzi A, Clark AL (2014) Biochem Biophys Res Commun 445(1): 184-90
    › Primary publication · 24495803 (PubMed) · PMC4022045 (PubMed Central)
  11. Discoidin domain receptors in disease. Borza CM, Pozzi A (2014) Matrix Biol : 185-92
    › Primary publication · 24361528 (PubMed) · PMC4019715 (PubMed Central)
  12. PPARα activation can help prevent and treat non-small cell lung cancer. Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A (2014) Cancer Res 74(2): 621-31
    › Primary publication · 24302581 (PubMed) · PMC3902646 (PubMed Central)
  13. Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis. Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X, Harris RC, Zhang MZ (2013) Mol Cancer Res 11(9): 1040-50
    › Primary publication · 23741059 (PubMed) · PMC3778073 (PubMed Central)
  14. Integrins in kidney disease. Pozzi A, Zent R (2013) J Am Soc Nephrol 24(7): 1034-9
    › Primary publication · 23641054 (PubMed) · PMC3699832 (PubMed Central)
  15. Deleting the TGF-β receptor attenuates acute proximal tubule injury. Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R (2012) J Am Soc Nephrol 23(12): 2001-11
    › Primary publication · 23160515 (PubMed) · PMC3507360 (PubMed Central)
  16. Cell responses to growth factors: the role of receptor tyrosine kinase intracellular domain fragments. Carpenter G, Pozzi A (2012) Sci Signal 5(243): pe42
    › Primary publication · 23012654 (PubMed)
  17. Connecting the segments. Zent R, Pozzi A (2012) J Am Soc Nephrol 23(10): 1603-5
    › Primary publication · 22975669 (PubMed)
  18. PI3-kinase and TGF-β in glomerular nephropathy: which comes first? Pozzi A (2012) Kidney Int 82(5): 507-9
    › Primary publication · 22892855 (PubMed) · PMC3725284 (PubMed Central)
  19. Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A (2012) J Biol Chem 287(42): 35139-52
    › Primary publication · 22888006 (PubMed) · PMC3471707 (PubMed Central)
  20. β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R (2012) Mol Cell Biol 32(20): 4080-91
    › Primary publication · 22869523 (PubMed) · PMC3457338 (PubMed Central)
  21. CD98 increases renal epithelial cell proliferation by activating MAPKs. Bulus N, Feral C, Pozzi A, Zent R (2012) PLoS One 7(6): e40026
    › Primary publication · 22768207 (PubMed) · PMC3386947 (PubMed Central)
  22. Inhibition of integrin α2β1 ameliorates glomerular injury. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A (2012) J Am Soc Nephrol 23(6): 1027-38
    › Primary publication · 22440900 (PubMed) · PMC3358756 (PubMed Central)
  23. The role of cell-extracellular matrix interactions in glomerular injury. Borza CM, Pozzi A (2012) Exp Cell Res 318(9): 1001-10
    › Primary publication · 22417893 (PubMed) · PMC3770307 (PubMed Central)
  24. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A (2012) Kidney Int 81(11): 1086-97
    › Primary publication · 22297672 (PubMed) · PMC3345314 (PubMed Central)
  25. Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations. Pozzi A, Zent R (2012) J Clin Invest 122(1): 13-6
    › Primary publication · 22201676 (PubMed) · PMC3248315 (PubMed Central)
  26. EET signaling in cancer. Panigrahy D, Greene ER, Pozzi A, Wang DW, Zeldin DC (2011) Cancer Metastasis Rev 30(3-4): 525-40
    › Primary publication · 22009066 (PubMed) · PMC3804913 (PubMed Central)
  27. Cyclooxygenases and lipoxygenases in cancer. Schneider C, Pozzi A (2011) Cancer Metastasis Rev 30(3-4): 277-94
    › Primary publication · 22002716 (PubMed) · PMC3798028 (PubMed Central)
  28. Integrins in renal development. Mathew S, Chen X, Pozzi A, Zent R (2012) Pediatr Nephrol 27(6): 891-900
    › Primary publication · 21603909 (PubMed)
  29. Extracellular matrix receptors in branched organs. Pozzi A, Zent R (2011) Curr Opin Cell Biol 23(5): 547-53
    › Primary publication · 21561755 (PubMed) · PMC3181278 (PubMed Central)
  30. TNFalpha accelerates monocyte to endothelial transdifferentiation in tumors by the induction of integrin alpha5 expression and adhesion to fibronectin. Li B, Pozzi A, Young PP (2011) Mol Cancer Res 9(6): 702-11
    › Primary publication · 21536688 (PubMed) · PMC3157289 (PubMed Central)
  31. Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways. Griesser M, Suzuki T, Tejera N, Mont S, Boeglin WE, Pozzi A, Schneider C (2011) Proc Natl Acad Sci U S A 108(17): 6945-50
    › Primary publication · 21482803 (PubMed) · PMC3084063 (PubMed Central)
  32. Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. Srichai MB, Colleta H, Gewin L, Matrisian L, Abel TW, Koshikawa N, Seiki M, Pozzi A, Harris RC, Zent R (2011) PLoS One 6(2): e17099
    › Primary publication · 21347258 (PubMed) · PMC3037967 (PubMed Central)
  33. TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation. Pozzi A, Zent R (2011) Am J Pathol 178(2): 485-9
    › Primary publication · 21281780 (PubMed) · PMC3069894 (PubMed Central)
  34. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH (2011) Diabetes 60(2): 416-26
    › Primary publication · 21270253 (PubMed) · PMC3028340 (PubMed Central)
  35. Diseased renal glomeruli are getting soft. Focus on "Biophysical properties of normal and diseased renal glomeruli". Pozzi A (2011) Am J Physiol Cell Physiol 300(3): C394-6
    › Primary publication · 21178112 (PubMed) · PMC3063959 (PubMed Central)
  36. Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q. Xue Q, Gu C, Rivera J, Höök M, Chen X, Pozzi A, Xu Y (2011) Cell Microbiol 13(4): 620-34
    › Primary publication · 21134100 (PubMed)
  37. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A (2010) J Biol Chem 285(51): 40114-24
    › Primary publication · 20940300 (PubMed) · PMC3000994 (PubMed Central)
  38. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Pozzi A, Zent R (2009) Wiley Interdiscip Rev Syst Biol Med 1(2): 254-272
    › Primary publication · 20835995 (PubMed) · PMC3789245 (PubMed Central)
  39. Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R (2010) Development 137(19): 3233-43
    › Primary publication · 20823064 (PubMed) · PMC2934735 (PubMed Central)
  40. MT1-MMP-mediated basement membrane remodeling modulates renal development. Riggins KS, Mernaugh G, Su Y, Quaranta V, Koshikawa N, Seiki M, Pozzi A, Zent R (2010) Exp Cell Res 316(17): 2993-3005
    › Primary publication · 20727881 (PubMed) · PMC2945451 (PubMed Central)
  41. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R (2010) J Am Soc Nephrol 21(8): 1334-43
    › Primary publication · 20576806 (PubMed) · PMC2938601 (PubMed Central)
  42. Induction of the renal stanniocalcin-1 gene in rodents by water deprivation. Turner J, Sazonova O, Wang H, Pozzi A, Wagner GF (2010) Mol Cell Endocrinol 328(1-2): 8-15
    › Primary publication · 20540985 (PubMed)
  43. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A (2010) Mol Cell Biol 30(12): 3048-58
    › Primary publication · 20368353 (PubMed) · PMC2876688 (PubMed Central)
  44. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. Pozzi A, Popescu V, Yang S, Mei S, Shi M, Puolitaival SM, Caprioli RM, Capdevila JH (2010) J Biol Chem 285(17): 12840-50
    › Primary publication · 20178979 (PubMed) · PMC2857132 (PubMed Central)
  45. ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation. Pozzi A, Zent R (2010) J Am Soc Nephrol 21(3): 388-90
    › Primary publication · 20133486 (PubMed) · PMC4473249 (PubMed Central)
  46. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV (2009) Blood 114(23): 4897-906
    › Primary publication · 19789387 (PubMed) · PMC2786295 (PubMed Central)
  47. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R (2009) Development 136(19): 3357-66
    › Primary publication · 19710172 (PubMed) · PMC2739149 (PubMed Central)
  48. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. Pozzi A, Zent R, Chetyrkin S, Borza C, Bulus N, Chuang P, Chen D, Hudson B, Voziyan P (2009) J Am Soc Nephrol 20(10): 2119-25
    › Primary publication · 19608705 (PubMed) · PMC2754111 (PubMed Central)
  49. The juxtamembrane region of the EGF receptor functions as an activation domain. Red Brewer M, Choi SH, Alvarado D, Moravcevic K, Pozzi A, Lemmon MA, Carpenter G (2009) Mol Cell 34(6): 641-51
    › Primary publication · 19560417 (PubMed) · PMC2719887 (PubMed Central)
  50. The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Yang S, Wei S, Pozzi A, Capdevila JH (2009) Arch Biochem Biophys 489(1-2): 82-91
    › Primary publication · 19464254 (PubMed) · PMC3786555 (PubMed Central)
  51. PLC-gamma1 regulates fibronectin assembly and cell aggregation. Crooke CE, Pozzi A, Carpenter GF (2009) Exp Cell Res 315(13): 2207-14
    › Primary publication · 19379731 (PubMed) · PMC2696586 (PubMed Central)
  52. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Pozzi A, Voziyan PA, Hudson BG, Zent R (2009) Curr Pharm Des 15(12): 1318-33
    › Primary publication · 19355971 (PubMed)
  53. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC (2009) J Clin Invest 119(4): 876-85
    › Primary publication · 19307727 (PubMed) · PMC2662561 (PubMed Central)
  54. Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2. Smith JP, Pozzi A, Dhawan P, Singh AB, Harris RC (2009) Am J Physiol Renal Physiol 296(5): F957-65
    › Primary publication · 19244405 (PubMed) · PMC2681361 (PubMed Central)
  55. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Antar AA, Konopka JL, Campbell JA, Henry RA, Perdigoto AL, Carter BD, Pozzi A, Abel TW, Dermody TS (2009) Cell Host Microbe 5(1): 59-71
    › Primary publication · 19154988 (PubMed) · PMC2642927 (PubMed Central)
  56. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL (2009) Cancer Res 69(2): 475-82
    › Primary publication · 19147560 (PubMed) · PMC2629389 (PubMed Central)
  57. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP (2008) Am J Pathol 173(5): 1577-88
    › Primary publication · 18832573 (PubMed) · PMC2570146 (PubMed Central)
  58. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R (2008) Exp Cell Res 314(19): 3593-604
    › Primary publication · 18809396 (PubMed) · PMC2729514 (PubMed Central)
  59. PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents. Pozzi A, Capdevila JH (2008) PPAR Res : 906542
    › Primary publication · 18725983 (PubMed) · PMC2517125 (PubMed Central)
  60. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R (2008) Cancer Res 68(15): 6224-31
    › Primary publication · 18676846 (PubMed)
  61. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A (2008) Cancer Res 68(15): 6127-35
    › Primary publication · 18676835 (PubMed) · PMC2801028 (PubMed Central)
  62. Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Abair TD, Bulus N, Borza C, Sundaramoorthy M, Zent R, Pozzi A (2008) Blood 112(8): 3242-54
    › Primary publication · 18647959 (PubMed) · PMC2569176 (PubMed Central)
  63. Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection. Taylor JL, Bielefeldt-Ohmann H, Pozzi A, Izzo AA (2008) Tuberculosis (Edinb) 88(5): 444-52
    › Primary publication · 18639492 (PubMed) · PMC2613756 (PubMed Central)
  64. Integrins, extracellular matrix, and terminal differentiation of renal epithelial cells. Pozzi A, Zent R (2008) J Am Soc Nephrol 19(6): 1043-4
    › Primary publication · 18480310 (PubMed)
  65. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R (2008) Dev Biol 316(2): 288-301
    › Primary publication · 18328474 (PubMed) · PMC2396524 (PubMed Central)
  66. Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Cosgrove D, Meehan DT, Delimont D, Pozzi A, Chen X, Rodgers KD, Tempero RM, Zallocchi M, Rao VH (2008) Am J Pathol 172(3): 761-73
    › Primary publication · 18258846 (PubMed) · PMC2258247 (PubMed Central)
  67. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. Borza CM, Borza DB, Pedchenko V, Saleem MA, Mathieson PW, Sado Y, Hudson HM, Pozzi A, Saus J, Abrahamson DR, Zent R, Hudson BG (2008) J Am Soc Nephrol 19(4): 677-84
    › Primary publication · 18235087 (PubMed) · PMC2390958 (PubMed Central)
  68. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. Macias-Perez IM, Zent R, Carmosino M, Breyer MD, Breyer RM, Pozzi A (2008) J Biol Chem 283(18): 12538-45
    › Primary publication · 18230618 (PubMed) · PMC2335350 (PubMed Central)
  69. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM (2008) Blood 111(4): 1980-8
    › Primary publication · 18042800 (PubMed) · PMC2234046 (PubMed Central)
  70. Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. Woodall BP, Nyström A, Iozzo RA, Eble JA, Niland S, Krieg T, Eckes B, Pozzi A, Iozzo RV (2008) J Biol Chem 283(4): 2335-43
    › Primary publication · 18024432 (PubMed)
  71. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS, Litingtung Y, Chiang C (2007) Am J Pathol 171(4): 1113-26
    › Primary publication · 17717145 (PubMed) · PMC1988863 (PubMed Central)
  72. Signaling pathways regulating TC21-induced tumorigenesis. Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R (2007) J Biol Chem 282(38): 27713-20
    › Primary publication · 17656362 (PubMed)
  73. Angiogenesis in diabetic nephropathy. Zent R, Pozzi A (2007) Semin Nephrol 27(2): 161-71
    › Primary publication · 17418685 (PubMed)
  74. Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. Pozzi A, Ibanez MR, Gatica AE, Yang S, Wei S, Mei S, Falck JR, Capdevila JH (2007) J Biol Chem 282(24): 17685-95
    › Primary publication · 17405874 (PubMed)
  75. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. Rao R, Redha R, Macias-Perez I, Su Y, Hao C, Zent R, Breyer MD, Pozzi A (2007) J Biol Chem 282(23): 16959-68
    › Primary publication · 17401137 (PubMed)
  76. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A (2007) Mol Cell Biol 27(9): 3313-26
    › Primary publication · 17339338 (PubMed) · PMC1899972 (PubMed Central)
  77. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Muñoz NM, Upton M, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM (2006) Cancer Res 66(20): 9837-44
    › Primary publication · 17047044 (PubMed)
  78. Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. Zweers MC, Davidson JM, Pozzi A, Hallinger R, Janz K, Quondamatteo F, Leutgeb B, Krieg T, Eckes B (2007) J Invest Dermatol 127(2): 467-78
    › Primary publication · 16977325 (PubMed)
  79. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Acuff HB, Sinnamon M, Fingleton B, Boone B, Levy SE, Chen X, Pozzi A, Carbone DP, Schwartz DR, Moin K, Sloane BF, Matrisian LM (2006) Cancer Res 66(16): 7968-75
    › Primary publication · 16912171 (PubMed)
  80. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB (2006) J Am Soc Nephrol 17(7): 1886-95
    › Primary publication · 16790514 (PubMed)
  81. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R (2006) J Biol Chem 281(30): 20932-9
    › Primary publication · 16731529 (PubMed)
  82. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH (2006) J Clin Invest 116(6): 1696-702
    › Primary publication · 16691295 (PubMed) · PMC1459070 (PubMed Central)
  83. H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis. Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R (2006) Mol Biol Cell 17(4): 2046-56
    › Primary publication · 16467383 (PubMed) · PMC1415315 (PubMed Central)
  84. Antiangiogenic therapy in diabetic nephropathy. Zent R, Pozzi A (2006) J Am Soc Nephrol 17(2): 325-7
    › Primary publication · 16434503 (PubMed)
  85. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. Mernaugh RL, Yan H, Chen D, Edl J, Hanley G, Pozzi A, Zent R (2005) J Immunol Methods 306(1-2): 115-27
    › Primary publication · 16212977 (PubMed)
  86. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A (2006) Am J Physiol Renal Physiol 290(1): F223-31
    › Primary publication · 16106035 (PubMed)
  87. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP (2005) Circ Res 97(5): 496-504
    › Primary publication · 16100039 (PubMed)
  88. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A (2005) Clin Exp Metastasis 22(2): 185-93
    › Primary publication · 16086239 (PubMed)
  89. Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Brábek J, Constancio SS, Siesser PF, Shin NY, Pozzi A, Hanks SK (2005) Mol Cancer Res 3(6): 307-15
    › Primary publication · 15972849 (PubMed)
  90. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH (2005) J Biol Chem 280(29): 27138-46
    › Primary publication · 15917237 (PubMed)
  91. Endo180 binds to the C-terminal region of type I collagen. Thomas EK, Nakamura M, Wienke D, Isacke CM, Pozzi A, Liang P (2005) J Biol Chem 280(24): 22596-605
    › Primary publication · 15817460 (PubMed)
  92. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A (2005) Int J Cancer 116(1): 52-61
    › Primary publication · 15756690 (PubMed)
  93. CD98 modulates integrin beta1 function in polarized epithelial cells. Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R (2005) J Cell Sci 118(Pt 5): 889-99
    › Primary publication · 15713750 (PubMed)
  94. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A (2004) Am J Pathol 165(2): 617-30
    › Primary publication · 15277235 (PubMed) · PMC1618576 (PubMed Central)
  95. CAS promotes invasiveness of Src-transformed cells. Brábek J, Constancio SS, Shin NY, Pozzi A, Weaver AM, Hanks SK (2004) Oncogene 23(44): 7406-15
    › Primary publication · 15273716 (PubMed)
  96. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R (2004) Am J Physiol Renal Physiol 287(4): F602-11
    › Primary publication · 15187002 (PubMed)
  97. Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. Pozzi A, Yan X, Macias-Perez I, Wei S, Hata AN, Breyer RM, Morrow JD, Capdevila JH (2004) J Biol Chem 279(28): 29797-804
    › Primary publication · 15123663 (PubMed)
  98. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J (2004) J Cell Sci 117(Pt 10): 2037-49
    › Primary publication · 15054110 (PubMed)
  99. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Ma LJ, Jha S, Ling H, Pozzi A, Ledbetter S, Fogo AB (2004) Kidney Int 65(1): 106-15
    › Primary publication · 14675041 (PubMed)
  100. Integrins: sensors of extracellular matrix and modulators of cell function. Pozzi A, Zent R (2003) Nephron Exp Nephrol 94(3): e77-84
    › Primary publication · 12902617 (PubMed)
  101. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD (2003) J Biol Chem 278(21): 19352-7
    › Primary publication · 12637551 (PubMed)
  102. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Brantley DM, Cheng N, Thompson EJ, Lin Q, Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D, Lin C, Chen J (2002) Oncogene 21(46): 7011-26
    › Primary publication · 12370823 (PubMed)
  103. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis. Pozzi A, LeVine WF, Gardner HA (2002) Oncogene 21(2): 272-81
    › Primary publication · 11803470 (PubMed)