Daniel Perrien
Last active: 4/1/2019


Dr. Perrien joined the VCBB in November 2008.  After receiving his Doctorate in Physiology and Biophysics from the University of Arkansas for Medical Sciences, he worked for an orthopaedic tissue engineering company, developing growth factor based drug/device therapies to enhance musculoskeletal repair.  Fracture repair and distraction osteogenesis continue to be major areas of investigation.  In addition, his efforts include mathematical modeling of structure-function relationships in bone, understanding the skeletal response to mechanical load, and endocrine control of bone mass and turnover.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. LNK deficiency promotes acute aortic dissection and rupture. Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS (2018) JCI Insight 3(20)
    › Primary publication · 30333305 (PubMed) · PMC6237478 (PubMed Central)
  2. The proto-oncogene function of Mdm2 in bone. Olivos DJ, Perrien DS, Hooker A, Cheng YH, Fuchs RK, Hong JM, Bruzzaniti A, Chun K, Eischen CM, Kacena MA, Mayo LD (2018) J Cell Biochem 119(11): 8830-8840
    › Primary publication · 30011084 (PubMed) · PMC6348883 (PubMed Central)
  3. Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone. Uppuganti S, Granke M, Manhard MK, Does MD, Perrien DS, Lee DH, Nyman JS (2017) J Orthop Res 35(7): 1442-1452
    › Primary publication · 27513922 (PubMed) · PMC5530367 (PubMed Central)
  4. Novel methods for microCT-based analyses of vasculature in the renal cortex reveal a loss of perfusable arterioles and glomeruli in eNOS-/- mice. Perrien DS, Saleh MA, Takahashi K, Madhur MS, Harrison DG, Harris RC, Takahashi T (2016) BMC Nephrol : 24
    › Primary publication · 26936597 (PubMed) · PMC4776352 (PubMed Central)
  5. The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease. Lima GM, Corazza BJ, Moraes RM, de Oliveira FE, de Oliveira LD, Franco GC, Perrien DS, Elefteriou F, Anbinder AL (2016) J Periodontal Res 51(5): 661-8
    › Primary publication · 26740292 (PubMed) · PMC5630139 (PubMed Central)
  6. Predicting mouse vertebra strength with micro-computed tomography-derived finite element analysis. Nyman JS, Uppuganti S, Makowski AJ, Rowland BJ, Merkel AR, Sterling JA, Bredbenner TL, Perrien DS (2015) Bonekey Rep : 664
    › Primary publication · 25908967 (PubMed) · PMC4407510 (PubMed Central)
  7. Corrigendum: Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F (2015) Nat Med 21(4): 414
    › Primary publication · 25849275 (PubMed)
  8. Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System. Vignaux G, Ndong JD, Perrien DS, Elefteriou F (2015) J Bone Miner Res 30(6): 1103-11
    › Primary publication · 25491117 (PubMed) · PMC4772960 (PubMed Central)
  9. Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F (2015) J Bone Miner Res 30(1): 55-63
    › Primary publication · 25043591 (PubMed) · PMC4280331 (PubMed Central)
  10. Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F (2014) Nat Med 20(8): 904-10
    › Primary publication · 24997609 (PubMed) · PMC4126855 (PubMed Central)
  11. Development of Raman spectral markers to assess metastatic bone in breast cancer. Ding H, Nyman JS, Sterling JA, Perrien DS, Mahadevan-Jansen A, Bi X (2014) J Biomed Opt 19(11): 111606
    › Primary publication · 24933683 (PubMed) · PMC4059340 (PubMed Central)
  12. Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice--a quantitative study using microCT and Raman spectroscopy. Bi X, Sterling JA, Merkel AR, Perrien DS, Nyman JS, Mahadevan-Jansen A (2013) Bone 56(2): 454-60
    › Primary publication · 23867219 (PubMed) · PMC3799839 (PubMed Central)
  13. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP (2013) Cell Host Microbe 13(6): 759-72
    › Primary publication · 23768499 (PubMed) · PMC3721972 (PubMed Central)
  14. Percutaneous injection of augment injectable bone graft (rhPDGF-BB and β-tricalcium phosphate [β-TCP]/bovine type I collagen matrix) increases vertebral bone mineral density in geriatric female baboons. Perrien DS, Young CS, Alvarez-Urena PP, Dean DD, Lynch SE, Hollinger JO (2013) Spine J 13(5): 580-6
    › Primary publication · 23541446 (PubMed)
  15. Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling. Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F (2013) J Bone Miner Res 28(4): 960-9
    › Primary publication · 23172686 (PubMed)
  16. Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. Campbell JP, Karolak MR, Ma Y, Perrien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA, Elefteriou F (2012) PLoS Biol 10(7): e1001363
    › Primary publication · 22815651 (PubMed) · PMC3398959 (PubMed Central)
  17. Effects of anti-tumor necrosis factor α agents on bone. Kawai VK, Stein CM, Perrien DS, Griffin MR (2012) Curr Opin Rheumatol 24(5): 576-85
    › Primary publication · 22810364 (PubMed) · PMC3753172 (PubMed Central)
  18. Maturational regression of glomeruli determines the nephron population in normal mice. Zhong J, Perrien DS, Yang HC, Kon V, Fogo AB, Ichikawa I, Ma J (2012) Pediatr Res 72(3): 241-8
    › Primary publication · 22717689 (PubMed) · PMC3605193 (PubMed Central)
  19. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J (2012) Am J Physiol Lung Cell Mol Physiol 302(5): L474-84
    › Primary publication · 22180660 (PubMed) · PMC3311512 (PubMed Central)
  20. Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. Biswas S, Nyman JS, Alvarez J, Chakrabarti A, Ayres A, Sterling J, Edwards J, Rana T, Johnson R, Perrien DS, Lonning S, Shyr Y, Matrisian LM, Mundy GR (2011) PLoS One 6(11): e27090
    › Primary publication · 22096521 (PubMed) · PMC3214031 (PubMed Central)
  21. Physiologically relevant oxidative degradation of oligo(proline) cross-linked polymeric scaffolds. Yu SS, Koblin RL, Zachman AL, Perrien DS, Hofmeister LH, Giorgio TD, Sung HJ (2011) Biomacromolecules 12(12): 4357-66
    › Primary publication · 22017359 (PubMed) · PMC3237771 (PubMed Central)
  22. Inhibin A enhances bone formation during distraction osteogenesis. Perrien DS, Nicks KM, Liu L, Akel NS, Bacon AW, Skinner RA, Swain FL, Aronson J, Suva LJ, Gaddy D (2012) J Orthop Res 30(2): 288-95
    › Primary publication · 21809377 (PubMed) · PMC3737578 (PubMed Central)
  23. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR (2011) J Bone Miner Res 26(6): 1252-60
    › Primary publication · 21611966 (PubMed) · PMC3312757 (PubMed Central)
  24. Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release. Brown KV, Li B, Guda T, Perrien DS, Guelcher SA, Wenke JC (2011) Tissue Eng Part A 17(13-14): 1735-46
    › Primary publication · 21338268 (PubMed)
  25. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS (2011) Dis Model Mech 4(3): 359-67
    › Primary publication · 21282722 (PubMed) · PMC3097457 (PubMed Central)
  26. Bone turnover across the menopause transition : The role of gonadal inhibins. Nicks KM, Fowler TW, Akel NS, Perrien DS, Suva LJ, Gaddy D (2010) Ann N Y Acad Sci : 153-60
    › Primary publication · 20392231 (PubMed) · PMC2964283 (PubMed Central)
  27. Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit. Dumas JE, Davis T, Holt GE, Yoshii T, Perrien DS, Nyman JS, Boyce T, Guelcher SA (2010) Acta Biomater 6(7): 2394-406
    › Primary publication · 20109586 (PubMed)
  28. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X (2009) Development 136(24): 4143-53
    › Primary publication · 19906842 (PubMed) · PMC2781050 (PubMed Central)
  29. Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin. Nicks KM, Perrien DS, Akel NS, Suva LJ, Gaddy D (2009) Mol Cell Endocrinol 310(1-2): 11-20
    › Primary publication · 19615428 (PubMed) · PMC2951729 (PubMed Central)
  30. Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus. Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK, Thrailkill KM (2008) Endocrinology 149(4): 1697-704
    › Primary publication · 18162513 (PubMed) · PMC2276714 (PubMed Central)
  31. Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats. Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK, Badger TM, Ronis MJ (2008) J Bone Miner Res 23(3): 338-49
    › Primary publication · 17967133 (PubMed)
  32. A novel rat model for the study of deficits in bone formation in type-2 diabetes. Liu Z, Aronson J, Wahl EC, Liu L, Perrien DS, Kern PA, Fowlkes JL, Thrailkill KM, Bunn RC, Cockrell GE, Skinner RA, Lumpkin CK (2007) Acta Orthop 78(1): 46-55
    › Primary publication · 17453392 (PubMed)
  33. Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: role of the TNF signaling axis. Wahl EC, Aronson J, Liu L, Liu Z, Perrien DS, Skinner RA, Badger TM, Ronis MJ, Lumpkin CK (2007) Toxicol Appl Pharmacol 220(3): 302-10
    › Primary publication · 17391719 (PubMed) · PMC1892174 (PubMed Central)
  34. Inhibin A is an endocrine stimulator of bone mass and strength. Perrien DS, Akel NS, Edwards PK, Carver AA, Bendre MS, Swain FL, Skinner RA, Hogue WR, Nicks KM, Pierson TM, Suva LJ, Gaddy D (2007) Endocrinology 148(4): 1654-65
    › Primary publication · 17194739 (PubMed)
  35. A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation. Wahl EC, Liu L, Perrien DS, Aronson J, Hogue WR, Skinner RA, Hidestrand M, Ronis MJ, Badger TM, Lumpkin CK (2006) Alcohol 39(3): 159-67
    › Primary publication · 17127135 (PubMed)
  36. Aging alters the skeletal response to disuse in the rat. Perrien DS, Akel NS, Dupont-Versteegden EE, Skinner RA, Siegel ER, Suva LJ, Gaddy D (2007) Am J Physiol Regul Integr Comp Physiol 292(2): R988-96
    › Primary publication · 17068163 (PubMed)
  37. Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model. Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Aronson J, Lumpkin CK (2006) J Bone Miner Res 21(9): 1359-66
    › Primary publication · 16939394 (PubMed) · PMC2424402 (PubMed Central)
  38. Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone. Perrien DS, Achenbach SJ, Bledsoe SE, Walser B, Suva LJ, Khosla S, Gaddy D (2006) J Clin Endocrinol Metab 91(5): 1848-54
    › Primary publication · 16449331 (PubMed)
  39. Bone formation is impaired in a model of type 1 diabetes. Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK (2005) Diabetes 54(10): 2875-81
    › Primary publication · 16186388 (PubMed)
  40. Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the tumor necrosis factor signaling axis. Wahl EC, Perrien DS, Aronson J, Liu Z, Fletcher TW, Skinner RA, Feige U, Suva LJ, Badger TM, Lumpkin CK (2005) Alcohol Clin Exp Res 29(8): 1466-72
    › Primary publication · 16131855 (PubMed)
  41. Regulation of bone mass by mechanical loading: microarchitecture and genetics. Suva LJ, Gaddy D, Perrien DS, Thomas RL, Findlay DM (2005) Curr Osteoporos Rep 3(2): 46-51
    › Primary publication · 16036101 (PubMed)
  42. IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats. Perrien DS, Wahl EC, Hogue WR, Feige U, Aronson J, Ronis MJ, Badger TM, Lumpkin CK (2004) Toxicol Sci 82(2): 656-60
    › Primary publication · 15470231 (PubMed)
  43. Chronic ethanol exposure is associated with a local increase in TNF-alpha and decreased proliferation in the rat distraction gap. Perrien DS, Liu Z, Wahl EC, Bunn RC, Skinner RA, Aronson J, Fowlkes J, Badger TM, Lumpkin CK (2003) Cytokine 23(6): 179-89
    › Primary publication · 12967643 (PubMed)
  44. Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis. Perrien DS, Brown EC, Fletcher TW, Irby DJ, Aronson J, Gao GG, Skinner RA, Hogue WR, Feige U, Suva LJ, Ronis MJ, Badger TM, Lumpkin CK (2002) J Pharmacol Exp Ther 303(3): 904-8
    › Primary publication · 12438508 (PubMed)
  45. Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. Brown EC, Perrien DS, Fletcher TW, Irby DJ, Aronson J, Gao GG, Hogue WJ, Skinner RA, Suva LJ, Ronis MJ, Hakkak R, Badger TM, Lumpkin CK (2002) J Pharmacol Exp Ther 301(3): 1132-8
    › Primary publication · 12023547 (PubMed)
  46. Immunohistochemical study of osteopontin expression during distraction osteogenesis in the rat. Perrien DS, Brown EC, Aronson J, Skinner RA, Montague DC, Badger TM, Lumpkin CK (2002) J Histochem Cytochem 50(4): 567-74
    › Primary publication · 11897810 (PubMed)