Jonathan Sheehan
Last active: 9/15/2017


Research Assistant Professor, Dept. of Biochemistry and Ctr. for Structural Biology

Computational Modeling and Simulation of Proteins and Nucleic Acid structures.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Kharade SV, Sheehan JH, Figueroa EE, Meiler J, Denton JS (2017) Mol Pharmacol 92(3): 338-346
    › Primary publication · 28619748 (PubMed) · PMC5553192 (PubMed Central)
  2. An Acquired Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Hanker AB, Brewer MR, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, Lovly CM, Meiler J, Arteaga CL (2017) Cancer Discov 7(6): 575-585
    › Primary publication · 28274957 (PubMed) · PMC5457707 (PubMed Central)
  3. Protocols for Molecular Modeling with Rosetta3 and RosettaScripts. Bender BJ, Cisneros A, Duran AM, Finn JA, Fu D, Lokits AD, Mueller BK, Sangha AK, Sauer MF, Sevy AM, Sliwoski G, Sheehan JH, DiMaio F, Meiler J, Moretti R (2016) Biochemistry 55(34): 4748-63
    › Primary publication · 27490953 (PubMed) · PMC5007558 (PubMed Central)
  4. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. Swale DR, Kurata H, Kharade SV, Sheehan J, Raphemot R, Voigtritter KR, Figueroa EE, Meiler J, Blobaum AL, Lindsley CW, Hopkins CR, Denton JS (2016) ACS Chem Neurosci 7(7): 1013-23
    › Primary publication · 27184474 (PubMed) · PMC5131535 (PubMed Central)
  5. EGFR Fusions as Novel Therapeutic Targets in Lung Cancer. Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E, Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, VavalĂ  T, Whiteley A, Chen H, Yan Y, Sheehan JH, Meiler J, Morosini D, Ross JS, Stephens PJ, Miller VA, Ali SM, Lovly CM (2016) Cancer Discov 6(6): 601-11
    › Primary publication · 27102076 (PubMed) · PMC4893907 (PubMed Central)
  6. The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy. Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL (2016) Expert Rev Clin Immunol 12(7): 763-73
    › Primary publication · 26864273 (PubMed) · PMC5070917 (PubMed Central)
  7. EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib. Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, Red Brewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J, Lovly CM (2015) Cancer Discov 5(11): 1155-63
    › Primary publication · 26286086 (PubMed) · PMC4631701 (PubMed Central)
  8. Computational and functional analyses of a small-molecule binding site in ROMK. Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS (2015) Biophys J 108(5): 1094-103
    › Primary publication · 25762321 (PubMed) · PMC4375722 (PubMed Central)
  9. Genetic analysis of the localization of APOBEC3F to human immunodeficiency virus type 1 virion cores. Donahue JP, Levinson RT, Sheehan JH, Sutton L, Taylor HE, Meiler J, D'Aquila RT, Song C (2015) J Virol 89(4): 2415-24
    › Primary publication · 25505075 (PubMed) · PMC4338907 (PubMed Central)
  10. NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression. Grabowska MM, Elliott AD, DeGraff DJ, Anderson PD, Anumanthan G, Yamashita H, Sun Q, Friedman DB, Hachey DL, Yu X, Sheehan JH, Ahn JM, Raj GV, Piston DW, Gronostajski RM, Matusik RJ (2014) Mol Endocrinol 28(6): 949-64
    › Primary publication · 24801505 (PubMed) · PMC4042066 (PubMed Central)
  11. Tailoring peptidomimetics for targeting protein-protein interactions. Akram ON, DeGraff DJ, Sheehan JH, Tilley WD, Matusik RJ, Ahn JM, Raj GV (2014) Mol Cancer Res 12(7): 967-78
    › Primary publication · 24642350 (PubMed)
  12. Small-molecule ligand docking into comparative models with Rosetta. Combs SA, Deluca SL, Deluca SH, Lemmon GH, Nannemann DP, Nguyen ED, Willis JR, Sheehan JH, Meiler J (2013) Nat Protoc 8(7): 1277-98
    › Primary publication · 23744289 (PubMed) · PMC5750396 (PubMed Central)
  13. Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock. Egli M, Pattanayek R, Sheehan JH, Xu Y, Mori T, Smith JA, Johnson CH (2013) Biochemistry 52(7): 1208-20
    › Primary publication · 23351065 (PubMed) · PMC3587310 (PubMed Central)
  14. Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C (2012) Retrovirology : 30
    › Primary publication · 22515365 (PubMed) · PMC3351742 (PubMed Central)
  15. Measurement of aptamer-protein interactions with back-scattering interferometry. Olmsted IR, Xiao Y, Cho M, Csordas AT, Sheehan JH, Meiler J, Soh HT, Bornhop DJ (2011) Anal Chem 83(23): 8867-70
    › Primary publication · 22032342 (PubMed)
  16. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL (2010) J Biol Chem 285(41): 31348-61
    › Primary publication · 20639197 (PubMed) · PMC2951209 (PubMed Central)
  17. Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker. Dave S, Sheehan JH, Meiler J, Strange K (2010) Channels (Austin) 4(4): 289-301
    › Primary publication · 20581474 (PubMed) · PMC3230521 (PubMed Central)
  18. Practically useful: what the Rosetta protein modeling suite can do for you. Kaufmann KW, Lemmon GH, Deluca SL, Sheehan JH, Meiler J (2010) Biochemistry 49(14): 2987-98
    › Primary publication · 20235548 (PubMed) · PMC2850155 (PubMed Central)
  19. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS (2009) Channels (Austin) 3(1): 57-68
    › Primary publication · 19221509 (PubMed) · PMC7968143 (PubMed Central)
  20. Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function. Sheehan JH, Bunick CG, Hu H, Fagan PA, Meyn SM, Chazin WJ (2006) J Biol Chem 281(5): 2876-81
    › Primary publication · 16317001 (PubMed)
  21. The mode of action of centrin. Binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain. Hu H, Sheehan JH, Chazin WJ (2004) J Biol Chem 279(49): 50895-903
    › Primary publication · 15452116 (PubMed)
  22. Designing sequence to control protein function in an EF-hand protein. Bunick CG, Nelson MR, Mangahas S, Hunter MJ, Sheehan JH, Mizoue LS, Bunick GJ, Chazin WJ (2004) J Am Chem Soc 126(19): 5990-8
    › Primary publication · 15137763 (PubMed)