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Key: MeSH Term KeywordAllosteric Regulation Animals cell culture Cyclic AMP Drug Evaluation, Preclinical Energy Metabolism Female Furocoumarins HEK293 Cells High-Throughput Screening Assays Highthroughput Screen Humans Indicators and Reagents Luciferase Reporter Luminescent Measurements Male melanocortin receptor Oxazines Phosphodiesterase Inhibitors Pilot Projects Receptor, Melanocortin, Type 4 Reproducibility of Results Signal Transduction Structure-Activity Relationship Sulfonamides Time Factors Xanthenes Zebrafish