Joseph Roland
Managing Director
Last active: 10/5/2017


Dr. Roland is an expert in cell and molecular biology. His research has helped him develop a deep, practical understanding of microscopic techniques. He is currently the managing director of the Digital Histology Shared Resource (DHSR) at Vanderbilt University Medical Center (VUMC). He has over 10 years of experience managing light microscopes and has been the Managing Director of the DHSR at VUMC since its launch in January of 2009. While he is well versed in many forms of microscopy, he has become a specialist in the field of whole-slide imaging and quantification. He is regularly contacted by external institutions for advice and guidance on the use of automated microscopes and has been involved in development and beta-testing of commercial scanning and analysis systems. Since 2012, he has been part of a group of researchers at VUMC working with engineers and computer scientists at General Electric’s (GE) Global Research Center to develop and validate a novel automated multiplexed imaging platform designed to identify large numbers of biomarkers in-situ.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity. McKinley ET, Sui Y, Al-Kofahi Y, Millis BA, Tyska MJ, Roland JT, Santamaria-Pang A, Ohland CL, Jobin C, Franklin JL, Lau KS, Gerdes MJ, Coffey RJ (2017) JCI Insight 2(11)
    › Primary publication · 28570279 (PubMed) · PMC5453701 (PubMed Central)
  2. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease. Vogel GF, Janecke AR, Krainer IM, Gutleben K, Witting B, Mitton SG, Mansour S, Ballauff A, Roland JT, Engevik AC, Cutz E, Müller T, Goldenring JR, Huber LA, Hess MW (2017) Traffic 18(7): 453-464
    › Primary publication · 28407399 (PubMed) · PMC5693299 (PubMed Central)
  3. Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. Jeong S, Choi E, Petersen CP, Roland JT, Federico A, Ippolito R, D'Armiento FP, Nardone G, Nagano O, Saya H, Romano M, Goldenring JR (2017) United European Gastroenterol J 5(1): 37-44
    › Primary publication · 28405320 (PubMed) · PMC5384548 (PubMed Central)
  4. Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus. Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D'Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ (2016) Cancer Res 76(22): 6657-6668
    › Primary publication · 27697767 (PubMed) · PMC5567825 (PubMed Central)
  5. MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma:  A Comparison With AMACR. Goldstein J, Goyal R, Roland JT, Gellert LL, Clark PE, Hameed O, Giannico GA (2016) Am J Clin Pathol 146(3): 294-302
    › Primary publication · 27543977 (PubMed)
  6. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Weis VG, Knowles BC, Choi E, Goldstein AE, Williams JA, Manning EH, Roland JT, Lapierre LA, Goldenring JR (2016) Cell Mol Gastroenterol Hepatol 2(2): 131-157
    › Primary publication · 27019864 (PubMed) · PMC4806369 (PubMed Central)
  7. MAGI-2 in prostate cancer: an immunohistochemical study. Goldstein J, Borowsky AD, Goyal R, Roland JT, Arnold SA, Gellert LL, Clark PE, Hameed O, Giannico GA (2016) Hum Pathol : 83-91
    › Primary publication · 26980016 (PubMed)
  8. Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. Knowles BC, Weis VG, Yu S, Roland JT, Williams JA, Alvarado GS, Lapierre LA, Shub MD, Gao N, Goldenring JR (2015) J Cell Sci 128(8): 1617-26
    › Primary publication · 25673875 (PubMed) · PMC4518445 (PubMed Central)
  9. Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease. Knowles BC, Roland JT, Krishnan M, Tyska MJ, Lapierre LA, Dickman PS, Goldenring JR, Shub MD (2014) J Clin Invest 124(7): 2947-62
    › Primary publication · 24892806 (PubMed) · PMC4071383 (PubMed Central)
  10. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR (2014) Gut 63(11): 1711-20
    › Primary publication · 24488499 (PubMed) · PMC4117823 (PubMed Central)
  11. Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Schafer JC, Baetz NW, Lapierre LA, McRae RE, Roland JT, Goldenring JR (2014) Traffic 15(3): 292-308
    › Primary publication · 24372966 (PubMed) · PMC4081500 (PubMed Central)
  12. TR3 modulates platinum resistance in ovarian cancer. Wilson AJ, Liu AY, Roland J, Adebayo OB, Fletcher SA, Slaughter JC, Saskowski J, Crispens MA, Jones HW, James S, Fadare O, Khabele D (2013) Cancer Res 73(15): 4758-69
    › Primary publication · 23720056 (PubMed) · PMC3944084 (PubMed Central)
  13. Sonic Hedgehog contributes to gastric mucosal restitution after injury. Xiao C, Feng R, Engevik AC, Martin JR, Tritschler JA, Schumacher M, Koncar R, Roland J, Nam KT, Goldenring JR, Zavros Y (2013) Lab Invest 93(1): 96-111
    › Citation · 23090636 (PubMed) · PMC3730822 (PubMed Central)
  14. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR (2012) Mol Biol Cell 23(12): 2302-18
    › Citation · 22553350 (PubMed) · PMC3374749 (PubMed Central)
  15. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin. Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD (2012) Gastroenterology 142(3): 562-571.e2
    › Citation · 22115830 (PubMed) · PMC3343368 (PubMed Central)
  16. Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. Mason TA, Kolobova E, Liu J, Roland JT, Chiang C, Goldenring JR (2011) PLoS One 6(11): e27699
    › Citation · 22110729 (PubMed) · PMC3216988 (PubMed Central)
  17. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR (2011) Proc Natl Acad Sci U S A 108(7): 2789-94
    › Citation · 21282656 (PubMed) · PMC3041130 (PubMed Central)
  18. Alternative splicing in class V myosins determines association with Rab10. Roland JT, Lapierre LA, Goldenring JR (2009) J Biol Chem 284(2): 1213-23
    › Citation · 19008234 (PubMed) · PMC2613619 (PubMed Central)
  19. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Roland JT, Kenworthy AK, Peranen J, Caplan S, Goldenring JR (2007) Mol Biol Cell 18(8): 2828-37
    › Citation · 17507647 (PubMed) · PMC1949367 (PubMed Central)
  20. CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. Pooley RD, Reddy S, Soukoulis V, Roland JT, Goldenring JR, Bader DM (2006) Mol Biol Cell 17(7): 3176-86
    › Citation · 16672379 (PubMed) · PMC1483049 (PubMed Central)
  21. Pigment cells: a model for the study of organelle transport. Nascimento AA, Roland JT, Gelfand VI (2003) Annu Rev Cell Dev Biol : 469-91
    › Citation · 14570578 (PubMed)
  22. Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI (2001) Science 293(5533): 1317-20
    › Citation · 11509731 (PubMed)
  23. Regulation of melanosome movement in the cell cycle by reversible association with myosin V. Rogers SL, Karcher RL, Roland JT, Minin AA, Steffen W, Gelfand VI (1999) J Cell Biol 146(6): 1265-76
    › Citation · 10491390 (PubMed) · PMC2156116 (PubMed Central)