florent Elefteriou
Associate Professor
Last active: 1/22/2015


I graduated in 2000 from Claude Bernard University in Lyon (France) with a PhD thesis focused on cell-extracellular matrix interactions. I trained as post-doctoral fellow in the laboratory of Dr. G. Karsenty at Baylor College of Medicine (Houston, TX), where I contributed to the characterization of the central and sympathetic nervous system as regulators of bone remodeling. During this period, I also had the opportunity to lead a project related to the skeletal complications seen in patients with neurofibromatosis type I (NF1), and to provide the first evidence for the role of neurofibromin in bone cells. It was also the time I met my wife, who made sure I’d stay in the US and who gave me confidence to transition to an independent scientist. In 2005, I took my first “real” job under the leadership of Dr. G. Mundy’s (UT Health Science Center, San Antonio), who introduced me to cancer and bone metastasis research. We moved in 2006 to Vanderbilt University (Nashville, TN) where I did not became a country music player or a gun owner but one of the core faculty of the new Vanderbilt Center for Bone Biology. Since then, I continued my research on NF1 and the role of the sympathetic nervous system on bone remodeling, and expanded my work to investigate early determinants of bone metastasis. I was promoted to the rank of Associate Professor on tenure in 2011 and took the direction of the Vanderbilt Center for Bone Biology, with the mission of facilitating multi-disciplinary and leading research in skeletal biology.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System. Vignaux G, Ndong JD, Perrien DS, Elefteriou F (2015) J Bone Miner Res 30(6): 1103-11
    › Primary publication · 25491117 (PubMed) · PMC4772960 (PubMed Central)
  2. Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F (2015) J Bone Miner Res 30(1): 55-63
    › Primary publication · 25043591 (PubMed) · PMC4280331 (PubMed Central)
  3. Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F (2014) Nat Med 20(8): 904-10
    › Primary publication · 24997609 (PubMed) · PMC4126855 (PubMed Central)
  4. Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models. Kühnisch J, Seto J, Lange C, Stumpp S, Kobus K, Grohmann J, Elefteriou F, Fratzl P, Mundlos S, Kolanczyk M (2014) Bone : 155-62
    › Primary publication · 24947449 (PubMed)
  5. Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1. Kühnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M (2014) PLoS One 9(1): e86115
    › Primary publication · 24465906 (PubMed) · PMC3897656 (PubMed Central)
  6. Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis. Ma Y, Krueger JJ, Redmon SN, Uppuganti S, Nyman JS, Hahn MK, Elefteriou F (2013) J Biol Chem 288(42): 30105-30113
    › Primary publication · 24005671 (PubMed) · PMC3798479 (PubMed Central)
  7. Control of bone remodeling by the peripheral sympathetic nervous system. Elefteriou F, Campbell P, Ma Y (2014) Calcif Tissue Int 94(1): 140-51
    › Primary publication · 23765388 (PubMed) · PMC3883940 (PubMed Central)
  8. The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation. Ono K, Karolak MR, Ndong Jde L, Wang W, Yang X, Elefteriou F (2013) Hum Mol Genet 22(15): 3048-62
    › Primary publication · 23571107 (PubMed) · PMC3999379 (PubMed Central)
  9. Bone remodeling is regulated by inner ear vestibular signals. Vignaux G, Besnard S, Ndong J, Philoxène B, Denise P, Elefteriou F (2013) J Bone Miner Res 28(10): 2136-44
    › Primary publication · 23553797 (PubMed)
  10. Approaches to treating NF1 tibial pseudarthrosis: consensus from the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Stevenson DA, Little D, Armstrong L, Crawford AH, Eastwood D, Friedman JM, Greggi T, Gutierrez G, Hunter-Schaedle K, Kendler DL, Kolanczyk M, Monsell F, Oetgen M, Richards BS, Schindeler A, Schorry EK, Wilkes D, Viskochil DH, Yang FC, Elefteriou F (2013) J Pediatr Orthop 33(3): 269-75
    › Primary publication · 23482262 (PubMed)
  11. Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling. Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F (2013) J Bone Miner Res 28(4): 960-9
    › Primary publication · 23172686 (PubMed)
  12. Models of bone metastasis. Campbell JP, Merkel AR, Masood-Campbell SK, Elefteriou F, Sterling JA (2012) J Vis Exp (67): e4260
    › Primary publication · 22972196 (PubMed) · PMC3490264 (PubMed Central)
  13. Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. Campbell JP, Karolak MR, Ma Y, Perrien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA, Elefteriou F (2012) PLoS Biol 10(7): e1001363
    › Primary publication · 22815651 (PubMed) · PMC3398959 (PubMed Central)
  14. Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X (2012) Development 139(3): 601-11
    › Primary publication · 22190639 (PubMed) · PMC3252356 (PubMed Central)
  15. Genetic mouse models for bone studies--strengths and limitations. Elefteriou F, Yang X (2011) Bone 49(6): 1242-54
    › Primary publication · 21907838 (PubMed) · PMC3331798 (PubMed Central)
  16. Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Wang W, Nyman JS, Ono K, Stevenson DA, Yang X, Elefteriou F (2011) Hum Mol Genet 20(20): 3910-24
    › Primary publication · 21757497 (PubMed) · PMC3177652 (PubMed Central)
  17. β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone. Ma Y, Nyman JS, Tao H, Moss HH, Yang X, Elefteriou F (2011) Endocrinology 152(4): 1412-22
    › Primary publication · 21266510 (PubMed) · PMC3060633 (PubMed Central)
  18. Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts. Wang W, Nyman JS, Moss HE, Gutierrez G, Mundy GR, Yang X, Elefteriou F (2010) J Bone Miner Res 25(7): 1658-67
    › Primary publication · 20200958 (PubMed) · PMC3154004 (PubMed Central)
  19. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X (2009) Development 136(24): 4143-53
    › Primary publication · 19906842 (PubMed) · PMC2781050 (PubMed Central)
  20. Skeletal abnormalities in neurofibromatosis type 1: approaches to therapeutic options. Elefteriou F, Kolanczyk M, Schindeler A, Viskochil DH, Hock JM, Schorry EK, Crawford AH, Friedman JM, Little D, Peltonen J, Carey JC, Feldman D, Yu X, Armstrong L, Birch P, Kendler DL, Mundlos S, Yang FC, Agiostratidou G, Hunter-Schaedle K, Stevenson DA (2009) Am J Med Genet A 149A(10): 2327-38
    › Primary publication · 19764036 (PubMed)
  21. Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation. Lian N, Wang W, Li L, Elefteriou F, Yang X (2009) J Biol Chem 284(44): 30518-25
    › Primary publication · 19726676 (PubMed) · PMC2781606 (PubMed Central)
  22. Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Singh MK, Elefteriou F, Karsenty G (2008) Endocrinology 149(8): 3933-41
    › Primary publication · 18450969 (PubMed) · PMC2488246 (PubMed Central)
  23. Regulation of bone remodeling by the central and peripheral nervous system. Elefteriou F (2008) Arch Biochem Biophys 473(2): 231-6
    › Primary publication · 18410742 (PubMed) · PMC2430105 (PubMed Central)
  24. The new field of neuroskeletal biology. Patel MS, Elefteriou F (2007) Calcif Tissue Int 80(5): 337-47
    › Primary publication · 17440766 (PubMed)
  25. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G (2006) Cell Metab 4(6): 441-51
    › Primary publication · 17141628 (PubMed) · PMC2756713 (PubMed Central)
  26. Boning up on ephrin signaling. Mundy GR, Elefteriou F (2006) Cell 126(3): 441-3
    › Primary publication · 16901775 (PubMed)
  27. Neuronal signaling and the regulation of bone remodeling. Elefteriou F (2005) Cell Mol Life Sci 62(19-20): 2339-49
    › Primary publication · 16132233 (PubMed)
  28. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G (2005) Nature 434(7032): 514-20
    › Primary publication · 15724149 (PubMed)
  29. Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. Cock TA, Back J, Elefteriou F, Karsenty G, Kastner P, Chan S, Auwerx J (2004) EMBO Rep 5(10): 1007-12
    › Primary publication · 15359271 (PubMed) · PMC1299154 (PubMed Central)
  30. [Bone mass regulation by leptin: a hypothalamic control of bone formation]. Elefteriou F, Karsenty G (2004) Pathol Biol (Paris) 52(3): 148-53
    › Primary publication · 15063934 (PubMed)
  31. Serum leptin level is a regulator of bone mass. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G (2004) Proc Natl Acad Sci U S A 101(9): 3258-63
    › Primary publication · 14978271 (PubMed) · PMC365777 (PubMed Central)
  32. Essential role of STAT3 in body weight and glucose homeostasis. Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li C (2004) Mol Cell Biol 24(1): 258-69
    › Primary publication · 14673160 (PubMed) · PMC303343 (PubMed Central)
  33. Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Elefteriou F, Takeda S, Liu X, Armstrong D, Karsenty G (2003) Endocrinology 144(9): 3842-7
    › Primary publication · 12933656 (PubMed)
  34. [Control of body mass by leptin occurs through the sympathetic nervous system]. Elefteriou F, Ducy P (2003) Med Sci (Paris) 19(4): 391-3
    › Primary publication · 12836204 (PubMed)
  35. Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Levasseur R, Barrios R, Elefteriou F, Glass DA, Lieberman MW, Karsenty G (2003) Endocrinology 144(7): 2761-4
    › Primary publication · 12810527 (PubMed)
  36. Common endocrine control of body weight, reproduction, and bone mass. Takeda S, Elefteriou F, Karsenty G (2003) Annu Rev Nutr : 403-11
    › Primary publication · 12730321 (PubMed)
  37. Leptin regulates bone formation via the sympathetic nervous system. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G (2002) Cell 111(3): 305-17
    › Primary publication · 12419242 (PubMed)
  38. Binding of tenascin-X to decorin. Elefteriou F, Exposito JY, Garrone R, Lethias C (2001) FEBS Lett 495(1-2): 44-7
    › Primary publication · 11322944 (PubMed)
  39. Identification and characterization of a conformational heparin-binding site involving two fibronectin type III modules of bovine tenascin-X. Lethias C, Elefteriou F, Parsiegla G, Exposito JY, Garrone R (2001) J Biol Chem 276(19): 16432-8
    › Primary publication · 11278641 (PubMed)
  40. Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors. Elefteriou F, Exposito JY, Garrone R, Lethias C (1999) Eur J Biochem 263(3): 840-8
    › Primary publication · 10469149 (PubMed)
  41. Characterization of the bovine tenascin-X. Elefteriou F, Exposito JY, Garrone R, Lethias C (1997) J Biol Chem 272(36): 22866-74
    › Primary publication · 9278449 (PubMed)