H. Alex Brown
Principle Investigator; Professor of Pharmacology, Chemistry, and Biochemistry; Associate Director, VICB;
Last active: 2/12/2015

Profile

Professor of Pharmacology, Chemistry, and Biochemistry

Associate Director, The Vanderbilt Institute of Chemical Biology

Investigator, The Vanderbilt Ingram Cancer Center

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas. Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA (2015) ACS Chem Biol 10(5): 1258-68
    › Primary publication · 25646564 (PubMed) · PMC4433586 (PubMed Central)
  2. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM (2015) Cell Rep 10(3): 326-338
    › Primary publication · 25600868 (PubMed) · PMC4501903 (PubMed Central)
  3. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA (2015) J Lipid Res 56(3): 722-36
    › Primary publication · 25598080 (PubMed) · PMC4340319 (PubMed Central)
  4. Biochemical characterization of a Pseudomonas aeruginosa phospholipase D. Spencer C, Brown HA (2015) Biochemistry 54(5): 1208-18
    › Primary publication · 25565226 (PubMed) · PMC4337821 (PubMed Central)
  5. Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition. O'Reilly MC, Scott SA, Brown HA, Lindsley CW (2014) Bioorg Med Chem Lett 24(24): 5553-5557
    › Primary publication · 25466173 (PubMed) · PMC4535313 (PubMed Central)
  6. Chemical modulation of glycerolipid signaling and metabolic pathways. Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA (2014) Biochim Biophys Acta 1841(8): 1060-84
    › Primary publication · 24440821 (PubMed) · PMC4069240 (PubMed Central)
  7. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. O'Reilly MC, Scott SA, Brown KA, Oguin TH, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW (2013) J Med Chem 56(6): 2695-9
    › Primary publication · 23445448 (PubMed) · PMC3632306 (PubMed Central)
  8. Sum of the parts: mass spectrometry-based metabolomics. Milne SB, Mathews TP, Myers DS, Ivanova PT, Brown HA (2013) Biochemistry 52(22): 3829-40
    › Primary publication · 23442130 (PubMed) · PMC3674197 (PubMed Central)
  9. Cobalt carbonyl complexes as probes for alkyne-tagged lipids. Tallman KA, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA (2013) J Lipid Res 54(3): 859-68
    › Primary publication · 23307946 (PubMed) · PMC3617960 (PubMed Central)
  10. Long term myriocin treatment increases MRP1 transport activity. Meszaros P, Klappe K, van Dam A, Ivanova PT, Milne SB, Myers DS, Brown HA, Permentier H, Hoekstra D, Kok JW (2013) Int J Biochem Cell Biol 45(2): 326-34
    › Primary publication · 23178537 (PubMed) · PMC3826170 (PubMed Central)
  11. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH (2012) J Clin Invest 122(11): 4130-44
    › Primary publication · 23023705 (PubMed) · PMC3484461 (PubMed Central)
  12. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK (2012) Cell 151(1): 138-52
    › Primary publication · 23021221 (PubMed) · PMC3464914 (PubMed Central)
  13. FAM83B mediates EGFR- and RAS-driven oncogenic transformation. Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, Jackson MW (2012) J Clin Invest 122(9): 3197-210
    › Primary publication · 22886302 (PubMed) · PMC3428078 (PubMed Central)
  14. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R (2012) Cell Metab 15(5): 691-702
    › Primary publication · 22560221 (PubMed) · PMC3361708 (PubMed Central)
  15. CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM (2012) Diabetes 61(2): 355-63
    › Primary publication · 22228714 (PubMed) · PMC3266405 (PubMed Central)
  16. Phospholipase D as a therapeutic target in brain disorders. Lindsley CW, Brown HA (2012) Neuropsychopharmacology 37(1): 301-2
    › Primary publication · 22157867 (PubMed) · PMC3238067 (PubMed Central)
  17. Introduction to lipid biochemistry, metabolism, and signaling. Brown HA, Marnett LJ (2011) Chem Rev 111(10): 5817-20
    › Primary publication · 21951202 (PubMed)
  18. Phospholipase D: enzymology, functionality, and chemical modulation. Selvy PE, Lavieri RR, Lindsley CW, Brown HA (2011) Chem Rev 111(10): 6064-119
    › Primary publication · 21936578 (PubMed) · PMC3233269 (PubMed Central)
  19. Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun MN, Wright JK, Matrisian LM, Brown HA (2011) PLoS One 6(8): e22775
    › Primary publication · 21857953 (PubMed) · PMC3153459 (PubMed Central)
  20. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Liu ST, Sharon-Friling R, Ivanova P, Milne SB, Myers DS, Rabinowitz JD, Brown HA, Shenk T (2011) Proc Natl Acad Sci U S A 108(31): 12869-74
    › Primary publication · 21768361 (PubMed) · PMC3150939 (PubMed Central)
  21. Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data handling, and interpretation. Myers DS, Ivanova PT, Milne SB, Brown HA (2011) Biochim Biophys Acta 1811(11): 748-57
    › Primary publication · 21683157 (PubMed) · PMC3292045 (PubMed Central)
  22. PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils. Norton LJ, Zhang Q, Saqib KM, Schrewe H, Macura K, Anderson KE, Lindsley CW, Brown HA, Rudge SA, Wakelam MJ (2011) J Cell Sci 124(Pt 12): 1973-83
    › Primary publication · 21610093 (PubMed) · PMC3104032 (PubMed Central)
  23. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S (2010) J Biol Chem 285(51): 39976-85
    › Primary publication · 20923771 (PubMed) · PMC3000979 (PubMed Central)
  24. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW (2010) J Med Chem 53(18): 6706-19
    › Primary publication · 20735042 (PubMed) · PMC3179181 (PubMed Central)
  25. Lipidomics reveals a remarkable diversity of lipids in human plasma. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA (2010) J Lipid Res 51(11): 3299-305
    › Primary publication · 20671299 (PubMed) · PMC2952570 (PubMed Central)
  26. Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1. Klappe K, Dijkhuis AJ, Hummel I, van Dam A, Ivanova PT, Milne SB, Myers DS, Brown HA, Permentier H, Kok JW (2010) Biochem J 430(3): 519-29
    › Primary publication · 20604746 (PubMed) · PMC3791605 (PubMed Central)
  27. Subcellular organelle lipidomics in TLR-4-activated macrophages. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA (2010) J Lipid Res 51(9): 2785-97
    › Primary publication · 20574076 (PubMed) · PMC2918461 (PubMed Central)
  28. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE (2010) J Leukoc Biol 87(6): 1041-57
    › Primary publication · 20200401 (PubMed) · PMC2872536 (PubMed Central)
  29. Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Milne SB, Tallman KA, Serwa R, Rouzer CA, Armstrong MD, Marnett LJ, Lukehart CM, Porter NA, Brown HA (2010) Nat Chem Biol 6(3): 205-207
    › Primary publication · 20098428 (PubMed) · PMC2822082 (PubMed Central)
  30. Molecular species of phosphatidylinositol-cycle intermediates in the endoplasmic reticulum and plasma membrane. Shulga YV, Myers DS, Ivanova PT, Milne SB, Brown HA, Topham MK, Epand RM (2010) Biochemistry 49(2): 312-7
    › Primary publication · 20000336 (PubMed) · PMC2805767 (PubMed Central)
  31. Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry. Ivanova PT, Milne SB, Brown HA (2010) J Lipid Res 51(6): 1581-90
    › Primary publication · 19965583 (PubMed) · PMC3035522 (PubMed Central)
  32. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. Lung M, Shulga YV, Ivanova PT, Myers DS, Milne SB, Brown HA, Topham MK, Epand RM (2009) J Biol Chem 284(45): 31062-73
    › Primary publication · 19744926 (PubMed) · PMC2781506 (PubMed Central)
  33. Lipidomics: a mass spectrometry based systems level analysis of cellular lipids. Ivanova PT, Milne SB, Myers DS, Brown HA (2009) Curr Opin Chem Biol 13(5-6): 526-31
    › Primary publication · 19744877 (PubMed) · PMC2787871 (PubMed Central)
  34. Working towards an exegesis for lipids in biology. Brown HA, Murphy RC (2009) Nat Chem Biol 5(9): 602-6
    › Primary publication · 19690530 (PubMed) · PMC3785062 (PubMed Central)
  35. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ (2009) J Neurochem 111(1): 15-25
    › Primary publication · 19627450 (PubMed) · PMC2752313 (PubMed Central)
  36. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE (2009) Mol Pharmacol 76(2): 301-13
    › Primary publication · 19483102 (PubMed) · PMC2713123 (PubMed Central)
  37. Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. Burnum KE, Cornett DS, Puolitaival SM, Milne SB, Myers DS, Tranguch S, Brown HA, Dey SK, Caprioli RM (2009) J Lipid Res 50(11): 2290-8
    › Primary publication · 19429885 (PubMed) · PMC2759835 (PubMed Central)
  38. Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Zeng XX, Zheng X, Xiang Y, Cho HP, Jessen JR, Zhong TP, Solnica-Krezel L, Brown HA (2009) Dev Biol 328(2): 363-76
    › Primary publication · 19389349 (PubMed) · PMC2688691 (PubMed Central)
  39. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW (2009) Bioorg Med Chem Lett 19(7): 1916-20
    › Primary publication · 19268584 (PubMed) · PMC3791604 (PubMed Central)
  40. Evidence that alpha-synuclein does not inhibit phospholipase D. Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ (2009) Biochemistry 48(5): 1077-83
    › Primary publication · 19146388 (PubMed) · PMC2683767 (PubMed Central)
  41. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA (2009) Nat Chem Biol 5(2): 108-17
    › Primary publication · 19136975 (PubMed) · PMC3798018 (PubMed Central)
  42. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ (2009) Mol Pharmacol 75(3): 577-88
    › Primary publication · 19047481 (PubMed) · PMC2684909 (PubMed Central)
  43. New mechanism for a classic folate inhibitor. Brown HA (2008) Nat Chem Biol 4(10): 581-2
    › Primary publication · 18800042 (PubMed)
  44. Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase. Milne SB, Ivanova PT, Armstrong MD, Myers DS, Lubarda J, Shulga YV, Topham MK, Brown HA, Epand RM (2008) Biochemistry 47(36): 9372-9
    › Primary publication · 18702510 (PubMed) · PMC2744458 (PubMed Central)
  45. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL (2008) Clin Cancer Res 14(13): 4267-74
    › Primary publication · 18594009 (PubMed) · PMC2759181 (PubMed Central)
  46. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J (2008) Proc Natl Acad Sci U S A 105(24): 8286-91
    › Primary publication · 18550814 (PubMed) · PMC2448829 (PubMed Central)
  47. Biochemical analysis of phospholipase D. Brown HA, Henage LG, Preininger AM, Xiang Y, Exton JH (2007) Methods Enzymol : 49-87
    › Primary publication · 17954242 (PubMed)
  48. Lipidomics and bioactive lipids: specialized analytical methods and lipids in disease. Preface. Brown HA (2007) Methods Enzymol : XV-XVI
    › Primary publication · 17954225 (PubMed)
  49. Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry. Ivanova PT, Milne SB, Byrne MO, Xiang Y, Brown HA (2007) Methods Enzymol : 21-57
    › Primary publication · 17954212 (PubMed)
  50. Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum. Murphy SC, Fernandez-Pol S, Chung PH, Prasanna Murthy SN, Milne SB, Salomao M, Brown HA, Lomasney JW, Mohandas N, Haldar K (2007) Blood 110(6): 2132-9
    › Primary publication · 17526861 (PubMed) · PMC1976375 (PubMed Central)
  51. Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages. Rouzer CA, Ivanova PT, Byrne MO, Brown HA, Marnett LJ (2007) Biochemistry 46(20): 6026-42
    › Primary publication · 17458939 (PubMed)
  52. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. Callender HL, Forrester JS, Ivanova P, Preininger A, Milne S, Brown HA (2007) Anal Chem 79(1): 263-72
    › Primary publication · 17194150 (PubMed)
  53. Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications. Rouzer CA, Ivanova PT, Byrne MO, Milne SB, Marnett LJ, Brown HA (2006) Biochemistry 45(49): 14795-808
    › Primary publication · 17144673 (PubMed) · PMC2443946 (PubMed Central)
  54. Direct modulation of phospholipase D activity by Gbetagamma. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA (2006) Mol Pharmacol 70(1): 311-8
    › Primary publication · 16638972 (PubMed)
  55. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. Henage LG, Exton JH, Brown HA (2006) J Biol Chem 281(6): 3408-17
    › Primary publication · 16339153 (PubMed) · PMC3800466 (PubMed Central)
  56. A targeted mass spectrometric analysis of phosphatidylinositol phosphate species. Milne SB, Ivanova PT, DeCamp D, Hsueh RC, Brown HA (2005) J Lipid Res 46(8): 1796-802
    › Primary publication · 15897608 (PubMed)
  57. A comprehensive classification system for lipids. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA (2005) J Lipid Res 46(5): 839-61
    › Primary publication · 15722563 (PubMed)
  58. LIPID arrays: new tools in the understanding of membrane dynamics and lipid signaling. Ivanova PT, Milne SB, Forrester JS, Brown HA (2004) Mol Interv 4(2): 86-96
    › Primary publication · 15087482 (PubMed)
  59. Computational lipidomics: a multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction. Forrester JS, Milne SB, Ivanova PT, Brown HA (2004) Mol Pharmacol 65(4): 813-21
    › Primary publication · 15044609 (PubMed)
  60. PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Fang Y, Park IH, Wu AL, Du G, Huang P, Frohman MA, Walker SJ, Brown HA, Chen J (2003) Curr Biol 13(23): 2037-44
    › Primary publication · 14653992 (PubMed)
  61. Measurement of G protein-coupled receptor-stimulated phospholipase D activity in intact cells. Walker SJ, Brown HA, Molecular and Cellular Biology, Cornell University, Ithaca, NY, USA (2004) Methods Mol Biol : 89-97
    › Primary publication · 14501041 (PubMed)
  62. Ordered and disordered phases coexist in plasma membrane vesicles of RBL-2H3 mast cells. An ESR study. Ge M, Gidwani A, Brown HA, Holowka D, Baird B, Freed JH (2003) Biophys J 85(2): 1278-88
    › Primary publication · 12885671 (PubMed) · PMC1303245 (PubMed Central)
  63. Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcepsilonRI. Gidwani A, Brown HA, Holowka D, Baird B (2003) J Cell Sci 116(Pt 15): 3177-87
    › Primary publication · 12829737 (PubMed)
  64. Overview of the Alliance for Cellular Signaling. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling (2002) Nature 420(6916): 703-6
    › Primary publication · 12478301 (PubMed)
  65. Role of protein kinase C betaII in influenza virus entry via late endosomes. Sieczkarski SB, Brown HA, Whittaker GR (2003) J Virol 77(1): 460-9
    › Primary publication · 12477851 (PubMed) · PMC140583 (PubMed Central)
  66. Selective estrogen receptor (ER) modulators differentially regulate phospholipase D catalytic activity in ER-negative breast cancer cells. Eisen SF, Brown HA (2002) Mol Pharmacol 62(4): 911-20
    › Primary publication · 12237338 (PubMed)
  67. Specificity of Rho insert-mediated activation of phospholipase D1. Walker SJ, Brown HA (2002) J Biol Chem 277(29): 26260-7
    › Primary publication · 12011045 (PubMed)
  68. A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Brooks MB, Catalfamo JL, Brown HA, Ivanova P, Lovaglio J (2002) Blood 99(7): 2434-41
    › Primary publication · 11895776 (PubMed)
  69. ADP ribosylation factor 6 binding to phosphatidylinositol 4,5-bisphosphate-containing vesicles creates defects in the bilayer structure: an electron spin resonance study. Ge M, Cohen JS, Brown HA, Freed JH (2001) Biophys J 81(2): 994-1005
    › Primary publication · 11463641 (PubMed) · PMC1301569 (PubMed Central)
  70. Electrospray ionization mass spectrometry analysis of changes in phospholipids in RBL-2H3 mastocytoma cells during degranulation. Ivanova PT, Cerda BA, Horn DM, Cohen JS, McLafferty FW, Brown HA (2001) Proc Natl Acad Sci U S A 98(13): 7152-7
    › Primary publication · 11416200 (PubMed) · PMC34638 (PubMed Central)
  71. Phospholipases stimulate secretion in RBL mast cells. Cohen JS, Brown HA (2001) Biochemistry 40(22): 6589-97
    › Primary publication · 11380253 (PubMed)
  72. Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase. Ganley IG, Walker SJ, Manifava M, Li D, Brown HA, Ktistakis NT (2001) Biochem J 354(Pt 2): 369-78
    › Primary publication · 11171116 (PubMed) · PMC1221665 (PubMed Central)
  73. Activation of phospholipase D1 by Cdc42 requires the Rho insert region. Walker SJ, Wu WJ, Cerione RA, Brown HA (2000) J Biol Chem 275(21): 15665-8
    › Primary publication · 10747870 (PubMed)
  74. Heterogeneous responses of cell Ca2+ in human airway epithelium. Paradiso AM, Brown HA, Ye H, Harden TK, Boucher RC (1999) Exp Lung Res 25(4): 277-90
    › Primary publication · 10378100 (PubMed)
  75. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Singer WD, Brown HA, Sternweis PC (1997) Annu Rev Biochem : 475-509
    › Primary publication · 9242915 (PubMed)
  76. Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Lazarowski ER, Watt WC, Stutts MJ, Brown HA, Boucher RC, Harden TK (1996) Br J Pharmacol 117(1): 203-9
    › Primary publication · 8825364 (PubMed) · PMC1909382 (PubMed Central)
  77. Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles. Ktistakis NT, Brown HA, Waters MG, Sternweis PC, Roth MG (1996) J Cell Biol 134(2): 295-306
    › Primary publication · 8707816 (PubMed) · PMC2120869 (PubMed Central)
  78. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. Singer WD, Brown HA, Jiang X, Sternweis PC (1996) J Biol Chem 271(8): 4504-10
    › Primary publication · 8626805 (PubMed)
  79. Stimulation of phospholipase D by ADP-ribosylation factor. Brown HA, Sternweis PC (1995) Methods Enzymol : 313-24
    › Primary publication · 8583935 (PubMed)
  80. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Brown HA, Gutowski S, Moomaw CR, Slaughter C, Sternweis PC (1993) Cell 75(6): 1137-44
    › Primary publication · 8261513 (PubMed)
  81. Resolved phospholipase D activity is modulated by cytosolic factors other than Arf. Singer WD, Brown HA, Bokoch GM, Sternweis PC (1995) J Biol Chem 270(25): 14944-50
    › Primary publication · 7797474 (PubMed)
  82. Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain. Brown HA, Gutowski S, Kahn RA, Sternweis PC (1995) J Biol Chem 270(25): 14935-43
    › Primary publication · 7797473 (PubMed)
  83. Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A. Ktistakis NT, Brown HA, Sternweis PC, Roth MG (1995) Proc Natl Acad Sci U S A 92(11): 4952-6
    › Primary publication · 7761430 (PubMed) · PMC41825 (PubMed Central)
  84. Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels. Palfai T, Wichlinski L, Brown HA, Brown OM (1986) Pharmacol Biochem Behav 24(5): 1457-9
    › Primary publication · 2873591 (PubMed)
  85. Biochemical properties of a P2Y-purinergic receptor. Harden TK, Boyer JL, Brown HA, Cooper CL, Jeffs RA, Martin MW (1990) Ann N Y Acad Sci : 256-66
    › Primary publication · 2291525 (PubMed)
  86. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. Brown HA, Lazarowski ER, Boucher RC, Harden TK (1991) Mol Pharmacol 40(5): 648-55
    › Primary publication · 1944236 (PubMed)

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  • H. Alex Brown Laboratory
    Principle Investigator; Professor of Pharmacology, Chemistry, and Biochemistry; Associate Director, VICB;
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Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Adipose Tissue Allosteric Regulation Bacillus cereus Calibration Carrier Proteins Cholera Toxin Cholesterol Cystic Fibrosis Cytokines Cytoplasm Electron Spin Resonance Spectroscopy Endoplasmic Reticulum Fatty Acids Female Halogenation Host-Pathogen Interactions Inflammation Mammary Glands, Human Mast Cells Mice, SCID Mice, Transgenic Molecular Weight Nasal Mucosa Phosphatidylglycerols Phosphatidylinositol 3-Kinases Protein Kinase C-alpha rap1 GTP-Binding Proteins RNA, Small Nuclear Saccharomyces cerevisiae Sphingolipids