We use systematic approach to understand how cancer cells respond to therapies. By utilizing high-throughput microscopy, image analysis, experimental techniques, and mathematical modeling, we examine the drug response behaviors of cancer cells and how they evolve during therapy- both an early and long term response.
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Key: MeSH Term KeywordCancer Research Cell Culture Techniques Cell Line Cell Line, Tumor Cell Proliferation Clonal Heterogeneity Clone Cells Computer Simulation Cycloheximide Dose-Response Relationship, Drug Drug Discovery Drug Response Dynamics Gene Expression Regulation Genetic Fitness Genetic Heterogeneity Humans Mathematical Modeling Microscopy, Fluorescence Models, Theoretical Molecular Biology Protein Synthesis Inhibitors Sensitivity and Specificity Small Molecule Libraries Systems Biology Time Factors