B. Paudel
PhD Candidate
Last active: 5/20/2018

B. B Paudel, B.S., Ph.D.

Official Affiliation: Biochemistry

Profile

We use systematic approach to understand how cancer cells respond to therapies. By utilizing high-throughput microscopy, image analysis, experimental techniques, and mathematical modeling, we examine the drug response behaviors of cancer cells and how they evolve during therapy- both an early and long term response. 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. A Nonquiescent "Idling" Population State in Drug-Treated, BRAF-Mutated Melanoma. Paudel BB, Harris LA, Hardeman KN, Abugable AA, Hayford CE, Tyson DR, Quaranta V (2018) Biophys J 114(6): 1499-1511
    › Primary publication · 29590606 (PubMed) · PMC5883941 (PubMed Central)
  2. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP (2017) Sci Rep : 42604
    › Primary publication · 28205616 (PubMed) · PMC5311997 (PubMed Central)
  3. An unbiased metric of antiproliferative drug effect in vitro. Harris LA, Frick PL, Garbett SP, Hardeman KN, Paudel BB, Lopez CF, Quaranta V, Tyson DR (2016) Nat Methods 13(6): 497-500
    › Primary publication · 27135974 (PubMed) · PMC4887341 (PubMed Central)
  4. Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. Frick PL, Paudel BB, Tyson DR, Quaranta V (2015) J Cell Physiol 230(7): 1403-12
    › Primary publication · 25600161 (PubMed) · PMC5580929 (PubMed Central)

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Keywords & MeSH Terms

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Key: MeSH Term Keyword

Antineoplastic Agents Cancer Research Cell Culture Techniques Cell Line Cell Line, Tumor Clonal Heterogeneity Clone Cells Computer Simulation Cycloheximide Dose-Response Relationship, Drug Drug Discovery Drug Resistance, Neoplasm Drug Response Dynamics Gene Expression Regulation Genetic Fitness Genetic Heterogeneity Glucose Glycolysis Humans Indoles Mathematical Modeling Melanoma Models, Theoretical Molecular Biology Molecular Targeted Therapy Mutation Oncogenes Pharmacogenomic Variants Phenotype Protein Synthesis Inhibitors Proto-Oncogene Proteins B-raf Sensitivity and Specificity Small Molecule Libraries Sulfonamides Systems Biology Time Factors Treatment Outcome