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We use systematic approach to understand how cancer cells respond to therapies. By utilizing high-throughput microscopy, image analysis, experimental techniques, and mathematical modeling, we examine the drug response behaviors of cancer cells and how they evolve during therapy- both an early and long term response.
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Key: MeSH Term KeywordAdaptation, Physiological Antineoplastic Agents Biochemical Phenomena Cancer Research Cell Culture Techniques Cell Line Cell Line, Tumor Clonal Heterogeneity Clone Cells Computer Simulation Cycloheximide Drug Combinations Drug Resistance, Neoplasm Drug Response Dynamics Drug Synergism Epigenesis, Genetic Gene Expression Regulation Genetic Fitness Genetic Heterogeneity Glucose Humans Indoles Mathematical Modeling Metabolic Networks and Pathways Molecular Targeted Therapy Mutation Neoplasms Pharmacogenomic Variants Phenotype Protein Synthesis Inhibitors Proto-Oncogene Proteins B-raf Sensitivity and Specificity Small Molecule Libraries Sulfonamides Systems Biology Time Factors Treatment Outcome