Profile

The Quaranta laboratory studies cancer cell proliferation, motility and metabolism by a systems biology approach. We subject cancer cells to drug perturbations (including addicting oncogene targeted drugs) and derive the response at the population level from single-cell data. Hundreds to thousands of single cells are monitored by automated microscopy coupled to image processing and data modeling. With respect to proliferation, we fractionate the cellular drug response into several behaviors, including entry into quiescence, apoptosis, or changes in division rate. For motility, we quantify changes in speed and persistence with models that apply to the single cell level, challenging cells with diverse substrates, especially laminins, and extracellular matrix proteases. Metabolism is monitored with respect to entry into aerobic glycolysis. These experimental data are integrated into computational models to predict and/or optimize drug response. Model predictions are validated in experimental tumors. Our interdisciplinary group is comprised of cell and molecular biologists, mathematicians, engineers, bioengineers, bioinformaticians and computational biologists.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again! Wooten DJ, Quaranta V (2017) Biochim Biophys Acta
    › Primary publication · 28396217 (PubMed)
  2. A mechanically coupled reaction-diffusion model that incorporates intra-tumoural heterogeneity to predict in vivo glioma growth. Hormuth DA, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V, Yankeelov TE (2017) J R Soc Interface 14(128)
    › Primary publication · 28330985 (PubMed) · PMC5378136 (PubMed Central)
  3. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP (2017) Sci Rep : 42604
    › Primary publication · 28205616 (PubMed) · PMC5311997 (PubMed Central)
  4. Integrin alpha6 maintains the structural integrity of the kidney collecting system. Viquez OM, Yazlovitskaya EM, Tu T, Mernaugh G, Secades P, McKee KK, Georges-Labouesse E, De Arcangelis A, Quaranta V, Yurchenco P, Gewin LC, Sonnenberg A, Pozzi A, Zent R (2017) Matrix Biol : 244-257
    › Primary publication · 28043890 (PubMed) · PMC5330664 (PubMed Central)
  5. Novel hybrid phenotype revealed in Small Cell Lung Cancer by a transcription factor network model that can explain tumor heterogeneity. Udyavar AR, Wooten DJ, Hoeksema MD, Bansal M, Califano A, Estrada L, Schnell S, Irish JM, Massion PP, Quaranta V (2016) Cancer Res
    › Primary publication · 27932399 (PubMed)
  6. Altered TGF-α/β signaling drives cooperation between breast cancer cell populations. Franco OE, Tyson DR, Konvinse KC, Udyavar AR, Estrada L, Quaranta V, Crawford SE, Hayward SW (2016) FASEB J 30(10): 3441-3452
    › Primary publication · 27383183 (PubMed) · PMC5024699 (PubMed Central)
  7. An unbiased metric of antiproliferative drug effect in vitro. Harris LA, Frick PL, Garbett SP, Hardeman KN, Paudel BB, Lopez CF, Quaranta V, Tyson DR (2016) Nat Methods 13(6): 497-500
    › Primary publication · 27135974 (PubMed) · PMC4887341 (PubMed Central)
  8. Predicting in vivo glioma growth with the reaction diffusion equation constrained by quantitative magnetic resonance imaging data. Hormuth DA, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V, Yankeelov TE (2015) Phys Biol 12(4): 046006
    › Primary publication · 26040472 (PubMed) · PMC4486062 (PubMed Central)
  9. Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R (2015) Mol Biol Cell 26(10): 1857-74
    › Primary publication · 25808491 (PubMed) · PMC4436831 (PubMed Central)
  10. Automated analysis of cell-matrix adhesions in 2D and 3D environments. Broussard JA, Diggins NL, Hummel S, Georgescu W, Quaranta V, Webb DJ (2015) Sci Rep : 8124
    › Primary publication · 25630460 (PubMed) · PMC4309964 (PubMed Central)
  11. Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. Frick PL, Paudel BB, Tyson DR, Quaranta V (2015) J Cell Physiol 230(7): 1403-12
    › Primary publication · 25600161 (PubMed)
  12. Toward a science of tumor forecasting for clinical oncology. Yankeelov TE, Quaranta V, Evans KJ, Rericha EC (2015) Cancer Res 75(6): 918-23
    › Primary publication · 25592148 (PubMed) · PMC4359948 (PubMed Central)
  13. Derivation and experimental comparison of cell-division probability densities. Leander R, Allen EJ, Garbett SP, Tyson DR, Quaranta V (2014) J Theor Biol : 129-35
    › Primary publication · 24931675 (PubMed)
  14. Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses. Tyson DR, Quaranta V (2013) Per Med 10(3): 221-225
    › Primary publication · 24696699 (PubMed) · PMC3970774 (PubMed Central)
  15. Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer. Udyavar AR, Hoeksema MD, Clark JE, Zou Y, Tang Z, Li Z, Li M, Chen H, Statnikov A, Shyr Y, Liebler DC, Field J, Eisenberg R, Estrada L, Massion PP, Quaranta V (2013) BMC Syst Biol : S1
    › Primary publication · 24564859 (PubMed) · PMC4029366 (PubMed Central)
  16. What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity. Quaranta V, Tyson DR (2013) Sci Signal 6(294): pe32
    › Primary publication · 24065144 (PubMed)
  17. Clinically relevant modeling of tumor growth and treatment response. Yankeelov TE, Atuegwu N, Hormuth D, Weis JA, Barnes SL, Miga MI, Rericha EC, Quaranta V (2013) Sci Transl Med 5(187): 187ps9
    › Primary publication · 23720579 (PubMed) · PMC3938952 (PubMed Central)
  18. Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis. Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM (2012) Sci Signal 5(241): ra66
    › Primary publication · 22969158 (PubMed) · PMC3583194 (PubMed Central)
  19. Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data. Tyson DR, Garbett SP, Frick PL, Quaranta V (2012) Nat Methods 9(9): 923-8
    › Primary publication · 22886092 (PubMed) · PMC3459330 (PubMed Central)
  20. The contribution of age structure to cell population responses to targeted therapeutics. Gabriel P, Garbett SP, Quaranta V, Tyson DR, Webb GF (2012) J Theor Biol : 19-27
    › Primary publication · 22796330 (PubMed) · PMC3592383 (PubMed Central)
  21. Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies. Hoshino D, Koshikawa N, Suzuki T, Quaranta V, Weaver AM, Seiki M, Ichikawa K (2012) PLoS Comput Biol 8(4): e1002479
    › Primary publication · 22511862 (PubMed) · PMC3325185 (PubMed Central)
  22. Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase. Takahashi K, Mernaugh RL, Friedman DB, Weller R, Tsuboi N, Yamashita H, Quaranta V, Takahashi T (2012) Proc Natl Acad Sci U S A 109(6): 1985-90
    › Primary publication · 22308318 (PubMed) · PMC3277540 (PubMed Central)
  23. CellAnimation: an open source MATLAB framework for microscopy assays. Georgescu W, Wikswo JP, Quaranta V (2012) Bioinformatics 28(1): 138-9
    › Primary publication · 22121157 (PubMed) · PMC3244774 (PubMed Central)
  24. Influence of cell cycle phase on apparent diffusion coefficient in synchronized cells detected using temporal diffusion spectroscopy. Xu J, Xie J, Jourquin J, Colvin DC, Does MD, Quaranta V, Gore JC (2011) Magn Reson Med 65(4): 920-6
    › Primary publication · 21413058 (PubMed) · PMC3433804 (PubMed Central)
  25. Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma. Rejniak KA, Quaranta V, Anderson AR (2012) Math Med Biol 29(1): 67-84
    › Primary publication · 21106672 (PubMed) · PMC3499074 (PubMed Central)
  26. Linking changes in epithelial morphogenesis to cancer mutations using computational modeling. Rejniak KA, Wang SE, Bryce NS, Chang H, Parvin B, Jourquin J, Estrada L, Gray JW, Arteaga CL, Weaver AM, Quaranta V, Anderson AR (2010) PLoS Comput Biol 6(8)
    › Primary publication · 20865159 (PubMed) · PMC2928778 (PubMed Central)
  27. Lysophosphatidic Acid Upregulates Laminin-332 Expression during A431 Cell Colony Dispersal. Yamashita H, Tripathi M, Jourquin J, Kam Y, Liu S, Weidow B, Quaranta V (2010) J Oncol
    › Primary publication · 20862207 (PubMed) · PMC2938436 (PubMed Central)
  28. Development of high-throughput quantitative assays for glucose uptake in cancer cell lines. Hassanein M, Weidow B, Koehler E, Bakane N, Garbett S, Shyr Y, Quaranta V (2011) Mol Imaging Biol 13(5): 840-52
    › Primary publication · 20809209 (PubMed) · PMC3627351 (PubMed Central)
  29. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP (2010) Oncogene 29(48): 6331-42
    › Primary publication · 20802517 (PubMed) · PMC4637980 (PubMed Central)
  30. MT1-MMP-mediated basement membrane remodeling modulates renal development. Riggins KS, Mernaugh G, Su Y, Quaranta V, Koshikawa N, Seiki M, Pozzi A, Zent R (2010) Exp Cell Res 316(17): 2993-3005
    › Primary publication · 20727881 (PubMed) · PMC2945451 (PubMed Central)
  31. Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells. Tripathi M, Potdar AA, Yamashita H, Weidow B, Cummings PT, Kirchhofer D, Quaranta V (2011) Prostate 71(2): 184-96
    › Primary publication · 20672321 (PubMed) · PMC3669684 (PubMed Central)
  32. Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility. Gruver JS, Potdar AA, Jeon J, Sai J, Anderson B, Webb D, Richmond A, Quaranta V, Cummings PT, Chung CY (2010) Biophys J 99(2): 367-76
    › Primary publication · 20643054 (PubMed) · PMC2905119 (PubMed Central)
  33. Not all noise is waste. Quaranta V, Garbett SP (2010) Nat Methods 7(4): 269-72
    › Primary publication · 20354516 (PubMed)
  34. The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration. Yamashita H, Tripathi M, Harris MP, Liu S, Weidow B, Zent R, Quaranta V (2010) Biomaterials 31(19): 5110-21
    › Primary publication · 20347131 (PubMed) · PMC2861493 (PubMed Central)
  35. Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain. Yamashita H, Shang M, Tripathi M, Jourquin J, Georgescu W, Liu S, Weidow B, Quaranta V (2010) J Cell Physiol 223(3): 541-8
    › Primary publication · 20301201 (PubMed) · PMC2874318 (PubMed Central)
  36. Human mammary epithelial cells exhibit a bimodal correlated random walk pattern. Potdar AA, Jeon J, Weaver AM, Quaranta V, Cummings PT (2010) PLoS One 5(3): e9636
    › Primary publication · 20224792 (PubMed) · PMC2835765 (PubMed Central)
  37. An off-lattice hybrid discrete-continuum model of tumor growth and invasion. Jeon J, Quaranta V, Cummings PT (2010) Biophys J 98(1): 37-47
    › Primary publication · 20074513 (PubMed) · PMC2800960 (PubMed Central)
  38. Laminin-332-beta1 integrin interactions negatively regulate invadopodia. Liu S, Yamashita H, Weidow B, Weaver AM, Quaranta V (2010) J Cell Physiol 223(1): 134-42
    › Primary publication · 20039268 (PubMed) · PMC3150482 (PubMed Central)
  39. Trait variability of cancer cells quantified by high-content automated microscopy of single cells. Quaranta V, Tyson DR, Garbett SP, Weidow B, Harris MP, Georgescu W (2009) Methods Enzymol : 23-57
    › Primary publication · 19897088 (PubMed) · PMC2915824 (PubMed Central)
  40. Microenvironmental independence associated with tumor progression. Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM (2009) Cancer Res 69(22): 8797-806
    › Primary publication · 19887618 (PubMed) · PMC2783510 (PubMed Central)
  41. Defining the role of laminin-332 in carcinoma. Guess CM, Quaranta V (2009) Matrix Biol 28(8): 445-55
    › Primary publication · 19686849 (PubMed) · PMC2875997 (PubMed Central)
  42. Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. Kam Y, Karperien A, Weidow B, Estrada L, Anderson AR, Quaranta V (2009) BMC Res Notes : 130
    › Primary publication · 19594934 (PubMed) · PMC2716356 (PubMed Central)
  43. A spatial model of tumor-host interaction: application of chemotherapy. Hinow P, Gerlee P, McCawley LJ, Quaranta V, Ciobanu M, Wang S, Graham JM, Ayati BP, Claridge J, Swanson KR, Loveless M, Anderson AR (2009) Math Biosci Eng 6(3): 521-46
    › Primary publication · 19566124 (PubMed) · PMC2981353 (PubMed Central)
  44. A decreased ratio of laminin-332 beta3 to gamma2 subunit mRNA is associated with poor prognosis in colon cancer. Guess CM, Lafleur BJ, Weidow BL, Quaranta V (2009) Cancer Epidemiol Biomarkers Prev 18(5): 1584-90
    › Primary publication · 19383890 (PubMed) · PMC2869450 (PubMed Central)
  45. Migration of isogenic cell lines quantified by dynamic multivariate analysis of single-cell motility. Harris MP, Kim E, Weidow B, Wikswo JP, Quaranta V (2008) Cell Adh Migr 2(2): 127-36
    › Primary publication · 19271355 (PubMed) · PMC2634586 (PubMed Central)
  46. Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. Kam Y, Quaranta V (2009) PLoS One 4(2): e4580
    › Primary publication · 19238201 (PubMed) · PMC2640460 (PubMed Central)
  47. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL (2009) Cancer Res 69(2): 475-82
    › Primary publication · 19147560 (PubMed) · PMC2629389 (PubMed Central)
  48. Microenvironment driven invasion: a multiscale multimodel investigation. Anderson AR, Rejniak KA, Gerlee P, Quaranta V (2009) J Math Biol 58(4-5): 579-624
    › Primary publication · 18839176 (PubMed)
  49. Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression. Tripathi M, Nandana S, Yamashita H, Ganesan R, Kirchhofer D, Quaranta V (2008) J Biol Chem 283(45): 30576-84
    › Primary publication · 18784072 (PubMed) · PMC2576550 (PubMed Central)
  50. A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. Kam Y, Guess C, Estrada L, Weidow B, Quaranta V (2008) BMC Cancer : 198
    › Primary publication · 18625060 (PubMed) · PMC2491634 (PubMed Central)
  51. Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Quaranta V, Rejniak KA, Gerlee P, Anderson AR (2008) Semin Cancer Biol 18(5): 338-48
    › Primary publication · 18524624 (PubMed) · PMC3789515 (PubMed Central)
  52. Integrative mathematical oncology. Anderson AR, Quaranta V (2008) Nat Rev Cancer 8(3): 227-34
    › Primary publication · 18273038 (PubMed)
  53. Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Georgescu W, Jourquin J, Estrada L, Anderson AR, Quaranta V, Wikswo JP (2008) Lab Chip 8(2): 238-44
    › Primary publication · 18231661 (PubMed) · PMC4357342 (PubMed Central)
  54. Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization. Klees RF, Salasznyk RM, Ward DF, Crone DE, Williams WA, Harris MP, Boskey A, Quaranta V, Plopper GE (2008) Exp Cell Res 314(4): 763-73
    › Primary publication · 18206871 (PubMed) · PMC2268764 (PubMed Central)
  55. Modeling of effects of nutrient gradients on cell proliferation in microfluidic bioreactor. Hu G, Quaranta V, Li D (2007) Biotechnol Prog 23(6): 1347-54
    › Primary publication · 17935347 (PubMed)
  56. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Anderson AR, Weaver AM, Cummings PT, Quaranta V (2006) Cell 127(5): 905-15
    › Primary publication · 17129778 (PubMed)
  57. Dispersal of epithelial cancer cell colonies by lysophosphatidic acid (LPA). Jourquin J, Yang N, Kam Y, Guess C, Quaranta V (2006) J Cell Physiol 206(2): 337-46
    › Primary publication · 16110477 (PubMed)
  58. A simplified laminin nomenclature. Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD (2005) Matrix Biol 24(5): 326-32
    › Primary publication · 15979864 (PubMed)
  59. Mathematical modeling of cancer: the future of prognosis and treatment. Quaranta V, Weaver AM, Cummings PT, Anderson AR (2005) Clin Chim Acta 357(2): 173-9
    › Primary publication · 15907826 (PubMed)
  60. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. Hintermann E, Yang N, O'Sullivan D, Higgins JM, Quaranta V (2005) J Biol Chem 280(9): 8004-15
    › Primary publication · 15579904 (PubMed)
  61. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain. Koshikawa N, Minegishi T, Sharabi A, Quaranta V, Seiki M (2005) J Biol Chem 280(1): 88-93
    › Primary publication · 15525652 (PubMed)
  62. Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors. Hintermann E, Quaranta V (2004) Matrix Biol 23(2): 75-85
    › Primary publication · 15246107 (PubMed)
  63. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. Wang H, Fu W, Im JH, Zhou Z, Santoro SA, Iyer V, DiPersio CM, Yu QC, Quaranta V, Al-Mehdi A, Muschel RJ (2004) J Cell Biol 164(6): 935-41
    › Primary publication · 15024036 (PubMed) · PMC2172296 (PubMed Central)
  64. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, Knöfler M, Andreae F, Wagner O, Quaranta V, Desoye G (2004) J Cell Sci 117(Pt 8): 1319-28
    › Primary publication · 15020672 (PubMed)
  65. The internal affairs of an integrin. Quaranta V, Jones JC (1991) Trends Cell Biol 1(1): 2-4
    › Primary publication · 14731802 (PubMed)
  66. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V (2004) FASEB J 18(2): 364-6
    › Primary publication · 14688206 (PubMed)
  67. Cancer invasion: watch your neighbourhood! Quaranta V, Giannelli G (2003) Tumori 89(4): 343-8
    › Primary publication · 14606634 (PubMed)
  68. Tissue remodelling in liver diseases. Giannelli G, Quaranta V, Antonaci S (2003) Histol Histopathol 18(4): 1267-74
    › Primary publication · 12973693 (PubMed)
  69. Tales from the crypt[ic] sites of the extracellular matrix. Schenk S, Quaranta V (2003) Trends Cell Biol 13(7): 366-75
    › Primary publication · 12837607 (PubMed)
  70. Remodeling of the microenvironment by aggressive melanoma tumor cells. Hendrix MJ, Seftor EA, Kirschmann DA, Quaranta V, Seftor RE (2003) Ann N Y Acad Sci : 151-61
    › Primary publication · 12814947 (PubMed)
  71. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. Schenk S, Hintermann E, Bilban M, Koshikawa N, Hojilla C, Khokha R, Quaranta V (2003) J Cell Biol 161(1): 197-209
    › Primary publication · 12695504 (PubMed) · PMC2172889 (PubMed Central)
  72. Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration. Pirilä E, Sharabi A, Salo T, Quaranta V, Tu H, Heljasvaara R, Koshikawa N, Sorsa T, Maisi P (2003) Biochem Biophys Res Commun 303(4): 1012-7
    › Primary publication · 12684035 (PubMed)
  73. De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods. Gao C, Mao S, Ronca F, Zhuang S, Quaranta V, Wirsching P, Janda KD (2003) J Immunol Methods 274(1-2): 185-97
    › Primary publication · 12609544 (PubMed)
  74. Motility cues in the tumor microenvironment. Quaranta V (2002) Differentiation 70(9-10): 590-8
    › Primary publication · 12492500 (PubMed)
  75. Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling. Hintermann E, Haake SK, Christen U, Sharabi A, Quaranta V (2002) Infect Immun 70(10): 5846-56
    › Primary publication · 12228316 (PubMed) · PMC128337 (PubMed Central)
  76. Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer. Bilban M, Buehler LK, Head S, Desoye G, Quaranta V (2002) BMC Genomics 3(1): 19
    › Primary publication · 12123529 (PubMed) · PMC117791 (PubMed Central)
  77. Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts. Faccio R, Grano M, Colucci S, Villa A, Giannelli G, Quaranta V, Zallone A (2002) J Cell Sci 115(Pt 14): 2919-29
    › Primary publication · 12082152 (PubMed)
  78. Normalizing DNA microarray data. Bilban M, Buehler LK, Head S, Desoye G, Quaranta V (2002) Curr Issues Mol Biol 4(2): 57-64
    › Primary publication · 11931570 (PubMed)
  79. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Zent R, Bush KT, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nigám SK (2001) Dev Biol 238(2): 289-302
    › Primary publication · 11784011 (PubMed)
  80. Characterization of morphological and cytoskeletal changes in MCF10A breast epithelial cells plated on laminin-5: comparison with breast cancer cell line MCF7. Kiosses WB, Hahn KM, Giannelli G, Quaranta V (2001) Cell Commun Adhes 8(1): 29-44
    › Primary publication · 11775027 (PubMed)
  81. Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, Bilban M, Stetler-Stevenson WG, Quaranta V, Hendrix MJ (2001) Cancer Res 61(17): 6322-7
    › Primary publication · 11522618 (PubMed)
  82. The LG3 module of laminin-5 harbors a binding site for integrin alpha3beta1 that promotes cell adhesion, spreading, and migration. Shang M, Koshikawa N, Schenk S, Quaranta V (2001) J Biol Chem 276(35): 33045-53
    › Primary publication · 11395486 (PubMed)
  83. Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. Hintermann E, Bilban M, Sharabi A, Quaranta V (2001) J Cell Biol 153(3): 465-78
    › Primary publication · 11331299 (PubMed) · PMC2190561 (PubMed Central)
  84. Human hepatocellular carcinoma (HCC) cells require both alpha3beta1 integrin and matrix metalloproteinases activity for migration and invasion. Giannelli G, Bergamini C, Fransvea E, Marinosci F, Quaranta V, Antonaci S (2001) Lab Invest 81(4): 613-27
    › Primary publication · 11304581 (PubMed)
  85. Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5. Plopper GE, Huff JL, Rust WL, Schwartz MA, Quaranta V (2000) Mol Cell Biol Res Commun 4(2): 129-35
    › Primary publication · 11170844 (PubMed)
  86. Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. Cirulli V, Beattie GM, Klier G, Ellisman M, Ricordi C, Quaranta V, Frasier F, Ishii JK, Hayek A, Salomon DR (2000) J Cell Biol 150(6): 1445-60
    › Primary publication · 10995448 (PubMed) · PMC2150716 (PubMed Central)
  87. Cell migration through extracellular matrix: membrane-type metalloproteinases make the way. Quaranta V (2000) J Cell Biol 149(6): 1167-70
    › Primary publication · 10851014 (PubMed) · PMC2175116 (PubMed Central)
  88. DNA microarrays: a novel approach to investigate genomics in trophoblast invasion--a review. Bilban M, Head S, Desoye G, Quaranta V (2000) Placenta : S99-105
    › Primary publication · 10831133 (PubMed)
  89. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. Koshikawa N, Giannelli G, Cirulli V, Miyazaki K, Quaranta V (2000) J Cell Biol 148(3): 615-24
    › Primary publication · 10662785 (PubMed) · PMC2174802 (PubMed Central)
  90. Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids. Giannelli G, Pozzi A, Stetler-Stevenson WG, Gardner HA, Quaranta V (1999) Am J Pathol 154(4): 1193-201
    › Primary publication · 10233857 (PubMed) · PMC1866557 (PubMed Central)
  91. Molecular cloning and characterization of CD4 in an aquatic mammal, the white whale Delphinapterus leucas. Romano TA, Ridgway SH, Felten DL, Quaranta V (1999) Immunogenetics 49(5): 376-83
    › Primary publication · 10199913 (PubMed)
  92. Evidence that laminin-5 is a component of the tooth surface internal basal lamina, supporting epithelial cell adhesion. Mullen LM, Richards DW, Quaranta V (1999) J Periodontal Res 34(1): 16-24
    › Primary publication · 10086882 (PubMed)
  93. Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins. Vivinus-Nebot M, Ticchioni M, Mary F, Hofman P, Quaranta V, Rousselle P, Bernard A (1999) J Cell Biol 144(3): 563-74
    › Primary publication · 9971749 (PubMed) · PMC2132916 (PubMed Central)
  94. Migration of breast epithelial cells on Laminin-5: differential role of integrins in normal and transformed cell types. Plopper GE, Domanico SZ, Cirulli V, Kiosses WB, Quaranta V (1998) Breast Cancer Res Treat 51(1): 57-69
    › Primary publication · 9877029 (PubMed)
  95. Mode of adsorption and orientation of an extracellular matrix protein affect its cell-adhesion-promoting activity. Fitchmun MI, Falk-Marzillier J, Marshall E, Cruz G, Jones JC, Quaranta V (1998) Anal Biochem 265(1): 1-7
    › Primary publication · 9866700 (PubMed)
  96. Characterization of a tight molecular complex between integrin alpha 6 beta 4 and laminin-5 extracellular matrix. Falk-Marzillier J, Domanico SZ, Pelletier A, Mullen L, Quaranta V (1998) Biochem Biophys Res Commun 251(1): 49-55
    › Primary publication · 9790905 (PubMed)
  97. Activation of alphav beta3 integrin on human osteoclast-like cells stimulates adhesion and migration in response to osteopontin. Faccio R, Grano M, Colucci S, Zallone AZ, Quaranta V, Pelletier AJ (1998) Biochem Biophys Res Commun 249(2): 522-5
    › Primary publication · 9712729 (PubMed)
  98. Differential regulation of integrins and extracellular matrix binding in epidermal differentiation and squamous tumor progression. Tennenbaum T, Belanger AJ, Quaranta V, Yuspa SH (1996) J Investig Dermatol Symp Proc 1(2): 157-61
    › Primary publication · 9627711 (PubMed)
  99. Alphav integrins mediate adhesion and migration of breast carcinoma cell lines. Wong NC, Mueller BM, Barbas CF, Ruminski P, Quaranta V, Lin EC, Smith JW (1998) Clin Exp Metastasis 16(1): 50-61
    › Primary publication · 9502077 (PubMed)
  100. Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Domanico SZ, Pelletier AJ, Havran WL, Quaranta V (1997) Mol Biol Cell 8(11): 2253-65
    › Primary publication · 9362067 (PubMed) · PMC25706 (PubMed Central)
  101. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997) Science 277(5323): 225-8
    › Primary publication · 9211848 (PubMed)
  102. Integrins and laminins in tissue remodeling. Quaranta V, Plopper GE (1997) Kidney Int 51(5): 1441-6
    › Primary publication · 9150456 (PubMed)
  103. Coating of titanium alloy with soluble laminin-5 promotes cell attachment and hemidesmosome assembly in gingival epithelial cells: potential application to dental implants. Tamura RN, Oda D, Quaranta V, Plopper G, Lambert R, Glaser S, Jones JC (1997) J Periodontal Res 32(3): 287-94
    › Primary publication · 9138194 (PubMed)
  104. Rapid disruption of an astrocyte interaction with the extracellular matrix mediated by integrin alpha 6 beta 4 during focal cerebral ischemia/reperfusion. Wagner S, Tagaya M, Koziol JA, Quaranta V, del Zoppo GJ (1997) Stroke 28(4): 858-65
    › Primary publication · 9099208 (PubMed)
  105. Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. Baker SE, Hopkinson SB, Fitchmun M, Andreason GL, Frasier F, Plopper G, Quaranta V, Jones JC (1996) J Cell Sci : 2509-20
    › Primary publication · 8923212 (PubMed)
  106. Morphogenetic effects of soluble laminin-5 on cultured epithelial cells and tissue explants. Baker SE, DiPasquale AP, Stock EL, Quaranta V, Fitchmun M, Jones JC (1996) Exp Cell Res 228(2): 262-70
    › Primary publication · 8912719 (PubMed)
  107. Changes in expression of monoclonal antibody epitopes on laminin-5r induced by cell contact. Plopper G, Falk-Marzillier J, Glaser S, Fitchmun M, Giannelli G, Romano T, Jones JC, Quaranta V (1996) J Cell Sci : 1965-73
    › Primary publication · 8832419 (PubMed)
  108. Human osteoclast-like cells selectively recognize laminin isoforms, an event that induces migration and activates Ca2+ mediated signals. Colucci S, Giannelli G, Grano M, Faccio R, Quaranta V, Zallone AZ (1996) J Cell Sci : 1527-35
    › Primary publication · 8799839 (PubMed)
  109. Altered expression of basement membrane proteins and their integrin receptors in lichen planus: possible pathogenetic role of gelatinases A and B. Giannelli G, Brassard J, Foti C, Stetler-Stevenson WG, Falk-Marzillier J, Zambonin-Zallone A, Schiraldi O, Quaranta V (1996) Lab Invest 74(6): 1091-104
    › Primary publication · 8667613 (PubMed)
  110. Evidence for a K+ channel requirement in spreading of rat basophilic leukemia cells on fibronectin-coated surfaces. Zigrino P, Gaietta G, Zambonin-Zallone A, Pelletier AJ, Quaranta V (1996) Biochem Biophys Res Commun 221(1): 51-8
    › Primary publication · 8660342 (PubMed)
  111. Activation of the integrin alpha v beta 3 involves a discrete cation-binding site that regulates conformation. Pelletier AJ, Kunicki T, Quaranta V (1996) J Biol Chem 271(3): 1364-70
    › Primary publication · 8576125 (PubMed)
  112. A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle. Collo G, Starr L, Quaranta V (1993) J Biol Chem 268(25): 19019-24
    › Primary publication · 8360188 (PubMed)
  113. Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent. Feltri ML, Scherer SS, Nemni R, Kamholz J, Vogelbacker H, Scott MO, Canal N, Quaranta V, Wrabetz L (1994) Development 120(5): 1287-301
    › Primary publication · 8026337 (PubMed)
  114. Psoriatic lesions in patients with chronic liver disease are distinct from psoriasis vulgaris lesions, as judged on basis of integrin adhesion receptors. Giannelli G, Savoia P, Schiraldi O, Lospalluti M, De Luca M, Marchisio PC, Quaranta V (1994) Hepatology 20(1 Pt 1): 56-65
    › Primary publication · 8020905 (PubMed)
  115. Quantitative measurement of alpha 6 beta 1 and alpha 6 beta 4 integrin internalization under cross-linking conditions: a possible role for alpha 6 cytoplasmic domains. Gaietta G, Redelmeier TE, Jackson MR, Tamura RN, Quaranta V (1994) J Cell Sci : 3339-49
    › Primary publication · 7706390 (PubMed)
  116. Immunolocalization of integrins in the normal and neoplastic colonic epithelium. Koukoulis GK, Virtanen I, Moll R, Quaranta V, Gould VE (1993) Virchows Arch B Cell Pathol Incl Mol Pathol 63(6): 373-83
    › Primary publication · 7686700 (PubMed)
  117. A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Tennenbaum T, Belanger AJ, Glick AB, Tamura R, Quaranta V, Yuspa SH (1995) Proc Natl Acad Sci U S A 92(15): 7041-5
    › Primary publication · 7624366 (PubMed) · PMC41467 (PubMed Central)
  118. Gradient of integrin alpha 6A distribution in the myocardium during early heart development. Collo G, Domanico SZ, Klier G, Quaranta V (1995) Cell Adhes Commun 3(2): 101-13
    › Primary publication · 7583004 (PubMed)
  119. Rapid spreading and mature hemidesmosome formation in HaCaT keratinocytes induced by incubation with soluble laminin-5r. Hormia M, Falk-Marzillier J, Plopper G, Tamura RN, Jones JC, Quaranta V (1995) J Invest Dermatol 105(4): 557-61
    › Primary publication · 7561158 (PubMed)
  120. The activation state of the integrin alpha IIb beta 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation. Pelletier AJ, Kunicki T, Ruggeri ZM, Quaranta V (1995) J Biol Chem 270(30): 18133-40
    › Primary publication · 7543096 (PubMed)
  121. A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6. Lehmann M, Rabenandrasana C, Tamura R, Lissitzky JC, Quaranta V, Pichon J, Marvaldi J (1994) Cancer Res 54(8): 2102-7
    › Primary publication · 7513610 (PubMed)
  122. Integrin cytoplasmic domains mediate inside-out signal transduction. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH (1994) J Cell Biol 124(6): 1047-59
    › Primary publication · 7510712 (PubMed) · PMC2119979 (PubMed Central)
  123. Lysis of cultured human melanoma M10 cells by polyclonal xenoantibodies to melanoma-associated antigens. Curry RA, Quaranta V, Pellegrino MA, Ferrone S (1981) Cancer Res 41(2): 463-6
    › Primary publication · 7448792 (PubMed)
  124. Natural cytotoxicity and antibody-dependent cellular cytotoxicity of human lymphocytes depleted of HLA-DR bearing cells with monoclonal HLA-DR antibodies. Ng AK, Indiveri F, Pellegrino MA, Molinaro GA, Quaranta V, Ferrone S (1980) J Immunol 124(5): 2336-40
    › Primary publication · 7365259 (PubMed)
  125. Tissue distribution of Ia-like antigens in different species: analysis with monoclonal antibodies. Natali PG, Quaranta V, Nicotra MR, Apollonj C, Pellegrino MA, Ferrone S (1981) Transplant Proc 13(1 Pt 2): 1026-9
    › Primary publication · 7022914 (PubMed)
  126. Expression of Ia-like antigens on the vasculature of human kidney. Natali PG, De Martino C, Marcellini M, Quaranta V, Ferrone S (1981) Clin Immunol Immunopathol 20(1): 11-20
    › Primary publication · 7021026 (PubMed)
  127. Expression of Ia-like antigens in normal human nonlymphoid tissues. Natali PG, De Martino C, Quaranta V, Nicotra MR, Frezza F, Pellegrino MA, Ferrone S (1981) Transplantation 31(1): 75-8
    › Primary publication · 7015604 (PubMed)
  128. Changes in Ia-like antigen expression on malignant human cells. Natali PG, De Martino C, Quaranta V, Bigotti A, Pellegrino MA, Ferrone S (1981) Immunogenetics 12(3-4): 409-13
    › Primary publication · 7009419 (PubMed)
  129. Level of Ia-like antigens on human B and T lymphocytes. Wilson BS, Indiveri F, Quaranta V, Pellegrino MA, Ferrone S (1981) Transplant Proc 13(1 Pt 2): 1033-4
    › Primary publication · 6973853 (PubMed)
  130. Characterization of DR antigens on cultured melanoma cells by using monoclonal antibodies. Wilson BS, Indiveri F, Molinaro GA, Quaranta V, Ferrone S (1980) Transplant Proc 12(1): 125-9
    › Primary publication · 6966094 (PubMed)
  131. Serological, functional, and immunochemical characterization of a monoclonal antibody (MoAb Q2/70) to human Ia-like antigens. Quaranta V, Indiveri F, Glassy MC, Ng A, Russo C, Molinaro GA, Pellegrino MA, Ferrone S (1980) Hum Immunol 1(3): 211-23
    › Primary publication · 6790480 (PubMed)
  132. Ia-like antigens on freshly explanted human melanoma. Natali PG, Cordiali-Fei P, Cavaliere R, Di Filippo F, Quaranta V, Pellegrino MA, Ferrone S (1981) Clin Immunol Immunopathol 19(2): 250-9
    › Primary publication · 6784988 (PubMed)
  133. Use of monoclonal antibodies to investigate immunologic cross-reactivity of histocompatibility antigens from various animal species. Russo C, Indiveri F, Quaranta V, Molinaro GA, Pellegrino MA, Ferrone S (1980) Transplant Proc 12(3): 376-9
    › Primary publication · 6784298 (PubMed)
  134. Monoclonal and polyclonal xenoantibodies to the HLA-A, B, C antigenic molecular complex do not affect the functional activity of C3 receptors. Indiveri F, Pellegrino MA, Quaranta V, Molinaro GA, Ferrone S (1980) Immunobiology 158(1-2): 17-21
    › Primary publication · 6782009 (PubMed)
  135. HLA complex and immune response in health and disease. Quaranta V (1983) Clin Physiol Biochem 1(2-5): 173-8
    › Primary publication · 6597048 (PubMed)
  136. Characterization of human null cells isolated from peripheral lymphocytes by a simultaneous double-rosetting procedure. Ng AK, Indiveri F, Russo C, Quaranta V, Pellegrino MA, Ferrone S (1981) Scand J Immunol 14(3): 225-31
    › Primary publication · 6460312 (PubMed)
  137. Stimulation of human T lymphocytes by PHA-activated autologous T lymphocytes: analysis of the role of Ia-like antigens with monoclonal antibodies. Russo C, Indiveri F, Quaranta V, Molinaro GA, Pellegrino MA, Ferrone S (1981) Immunogenetics 12(3-4): 267-74
    › Primary publication · 6451578 (PubMed)
  138. Ia-like antigens on human T lymphocytes: relationship to other surface markers, role in mixed lymphocyte reactions, and structural profile. Indiveri F, Wilson BS, Russo C, Quaranta V, Pellegrino MA, Ferrone S (1980) J Immunol 125(6): 2673-8
    › Primary publication · 6448901 (PubMed)
  139. Effect of polyclonal and monoclonal HLA-DR xenoantibodies on xenogeneic mixed lymphocyte reactions. Russo C, Quaranta V, Indiveri F, Pellegrino MA, Ferrone S (1980) Immunogenetics 11(4): 413-6
    › Primary publication · 6448810 (PubMed)
  140. The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Glenner GG, Wong CW, Quaranta V, Eanes ED (1984) Appl Pathol 2(6): 357-69
    › Primary publication · 6242724 (PubMed)
  141. A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3). Quaranta V, Majdic O, Stingl G, Liszka K, Honigsmann H, Knapp W (1984) J Immunol 132(4): 1900-5
    › Primary publication · 6199417 (PubMed)
  142. A recurrent idiotype on monoclonal anti-human Ia antibodies. Quaranta V, Zanetti M, Reisfeld RA (1982) J Exp Med 156(5): 1551-6
    › Primary publication · 6182263 (PubMed) · PMC2186848 (PubMed Central)
  143. The monoclonal xenoantibody Q6/64 recognizes a determinant expressed by certain gene products of the A and B loci of the HLA region. Quaranta V, Pellegrino MA, Ferrone S (1981) Immunogenetics 14(5): 403-13
    › Primary publication · 6174438 (PubMed)
  144. Effect of tunicamycin on the assembly and antigenicity of HLA antigens: analysis with monoclonal antibodies. Wilson BS, Glassy MC, Quaranta V, Ng AK, Ferrone S (1981) Scand J Immunol 14(2): 201-5
    › Primary publication · 6171878 (PubMed)
  145. HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13. Indiveri F, Russo C, Quaranta V, Pellegrino MA, Ferrone S (1981) Cell Immunol 62(2): 406-11
    › Primary publication · 6169455 (PubMed)
  146. Cross-reactivity between human and murine lymphocyte antigens. IV. Reactivity of H-2 alloantisera with HLA-A, B antigens. Quaranta V, Pellegrino MA, Callahan GN, Ferrone S (1981) Immunogenetics 13(4): 311-7
    › Primary publication · 6168581 (PubMed)
  147. The free and the beta 2-microglobulin-associated heavy chains of HLA-A, B alloantigens share the antigenic determinant recognized by the monoclonal antibody Q1/28. Quaranta V, Walker LE, Ruberto G, Pellegrino MA, Ferrone S (1981) Immunogenetics 13(4): 285-95
    › Primary publication · 6168579 (PubMed)
  148. Distribution of antigenic determinants recognized by three monoclonal antibodies (Q2/70, Q5/6 and Q5/13) on human Ia-like alloantigens and on their subunits. Quaranta V, Tanigaki N, Ferrone S (1981) Immunogenetics 12(1-2): 175-82
    › Primary publication · 6162791 (PubMed)
  149. Isolation of Ia-like antigen-bearing cells from human peripheral lymphocytes through the use of a monoclonal antibody to framework determinants of Ia-like antigens. Indiveri F, Ng AK, Russo C, Quaranta V, Pellegrino MA, Ferrone S (1980) J Immunol Methods 39(4): 343-54
    › Primary publication · 6161968 (PubMed)
  150. Serologic and immunochemical characterization of the specificity of four monoclonal antibodies to distinct antigenic determinants expressed on subpopulations of human Ia-like antigens. Quaranta V, Pellegrino MA, Ferrone S (1981) J Immunol 126(2): 548-52
    › Primary publication · 6161181 (PubMed)
  151. Monoclonal antibodies to HLA-A,B, and Ia-like antigens inhibit colony formation by human myeloid progenitor cells. Fitchen JH, Ferrone S, Quaranta V, Molinaro GA, Cline MJ (1980) J Immunol 125(5): 2004-8
    › Primary publication · 6159398 (PubMed)
  152. Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent. Quaranta V, Walker LE, Pellegrino MA, Ferrone S (1980) J Immunol 125(4): 1421-5
    › Primary publication · 6157732 (PubMed)
  153. Ammonium chloride interferes with a distinct step in the biosynthesis and cell surface expression of human melanoma-type chondroitin sulfate proteoglycan. Harper JR, Quaranta V, Reisfeld RA (1986) J Biol Chem 261(8): 3600-6
    › Primary publication · 3949779 (PubMed)
  154. Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells. Nowell J, Quaranta V (1985) J Exp Med 162(4): 1371-6
    › Primary publication · 3930653 (PubMed) · PMC2187864 (PubMed Central)
  155. Six monoclonal antibodies to human pancreatic cancer antigens. Kajiji SM, Davceva B, Quaranta V (1987) Cancer Res 47(5): 1367-76
    › Primary publication · 3815343 (PubMed)
  156. Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion. Posillico JT, Srikanta S, Eisenbarth G, Quaranta V, Kajiji S, Brown EM (1987) J Clin Endocrinol Metab 64(1): 43-50
    › Primary publication · 3782435 (PubMed)
  157. An ELISA for detection of DNA-bound carcinogen using a monoclonal antibody to N-acetoxy-2-acetylaminofluorene-modified DNA. Ball SS, Quaranta V, Shadravan F, Walford RL (1987) J Immunol Methods 98(2): 195-200
    › Primary publication · 3571986 (PubMed)
  158. Monoclonal antibody-mediated modulation of parathyroid hormone secretion by dispersed parathyroid cells. Posillico JT, Wilson RE, Srikanta SS, Eisenbarth GS, Letarte M, Quackenbush EJ, Quaranta V, Kajaji S, Brown EM (1987) Arch Surg 122(4): 436-42
    › Primary publication · 3551881 (PubMed)
  159. The human invariant chain is the core protein of the human class II-associated proteoglycan. Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD (1986) J Exp Med 164(5): 1422-39
    › Primary publication · 3464690 (PubMed) · PMC2188463 (PubMed Central)
  160. Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes. O'Sullivan DM, Larhammar D, Wilson MC, Peterson PA, Quaranta V (1986) Proc Natl Acad Sci U S A 83(12): 4484-8
    › Primary publication · 3459184 (PubMed) · PMC323758 (PubMed Central)
  161. Sulfated N-linked oligosaccharides in mammalian cells. III. Characterization of a pancreatic carcinoma cell surface glycoprotein with N- and O-sulfate esters on asparagine-linked glycans. Sundblad G, Kajiji S, Quaranta V, Freeze HH, Varki A (1988) J Biol Chem 263(18): 8897-903
    › Primary publication · 3379052 (PubMed)
  162. Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation. O'Sullivan DM, Noonan D, Quaranta V (1987) J Exp Med 166(2): 444-60
    › Primary publication · 3036998 (PubMed) · PMC2189580 (PubMed Central)
  163. The HLA-class II-associated chondroitin sulfate proteoglycan expressed by class II positive T and monocyte-like cell lines is larger than that expressed by EBV-transformed B-lymphoblastoid cell lines. Bono C, Pereira MB, O'Sullivan DM, Quaranta V, Schwartz BD (1987) Hum Immunol 18(4): 315-30
    › Primary publication · 3032875 (PubMed)
  164. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Wong CW, Quaranta V, Glenner GG (1985) Proc Natl Acad Sci U S A 82(24): 8729-32
    › Primary publication · 2934737 (PubMed) · PMC391510 (PubMed Central)
  165. A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. Kajiji S, Tamura RN, Quaranta V (1989) EMBO J 8(3): 673-80
    › Primary publication · 2542022 (PubMed) · PMC400860 (PubMed Central)
  166. Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice. Lawrance SK, Karlsson L, Price J, Quaranta V, Ron Y, Sprent J, Peterson PA (1989) Cell 58(3): 583-94
    › Primary publication · 2527088 (PubMed)
  167. The invariant chain is a phosphorylated subunit of class II molecules. Spiro RC, Quaranta V (1989) J Immunol 143(8): 2589-94
    › Primary publication · 2507633 (PubMed)
  168. A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. Cheresh DA, Smith JW, Cooper HM, Quaranta V (1989) Cell 57(1): 59-69
    › Primary publication · 2467745 (PubMed)
  169. Polarized integrin mediates human keratinocyte adhesion to basal lamina. De Luca M, Tamura RN, Kajiji S, Bondanza S, Rossino P, Cancedda R, Marchisio PC, Quaranta V (1990) Proc Natl Acad Sci U S A 87(17): 6888-92
    › Primary publication · 2395883 (PubMed) · PMC54643 (PubMed Central)
  170. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R (1990) J Biol Chem 265(20): 11502-7
    › Primary publication · 2365683 (PubMed)
  171. Intracellular transport of class II MHC molecules directed by invariant chain. Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL, Quaranta V, Peterson PA (1990) Nature 348(6302): 600-5
    › Primary publication · 2250716 (PubMed)
  172. Epithelial integrins. Quaranta V (1990) Cell Differ Dev 32(3): 361-5
    › Primary publication · 2151568 (PubMed)
  173. Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V (1990) J Cell Biol 111(4): 1593-604
    › Primary publication · 1976638 (PubMed) · PMC2116232 (PubMed Central)
  174. Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Tamura RN, Cooper HM, Collo G, Quaranta V (1991) Proc Natl Acad Sci U S A 88(22): 10183-7
    › Primary publication · 1946438 (PubMed) · PMC52892 (PubMed Central)
  175. Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules. Koukoulis GK, Virtanen I, Korhonen M, Laitinen L, Quaranta V, Gould VE (1991) Am J Pathol 139(4): 787-99
    › Primary publication · 1928301 (PubMed) · PMC1886301 (PubMed Central)
  176. Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta. Korhonen M, Ylänne J, Laitinen L, Cooper HM, Quaranta V, Virtanen I (1991) Lab Invest 65(3): 347-56
    › Primary publication · 1890813 (PubMed)
  177. A function for the integrin alpha 6 beta 4 in the hemidesmosome. Jones JC, Kurpakus MA, Cooper HM, Quaranta V (1991) Cell Regul 2(6): 427-38
    › Primary publication · 1883873 (PubMed) · PMC361825 (PubMed Central)
  178. The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. Cooper HM, Tamura RN, Quaranta V (1991) J Cell Biol 115(3): 843-50
    › Primary publication · 1833411 (PubMed) · PMC2289180 (PubMed Central)
  179. Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation. de Curtis I, Quaranta V, Tamura RN, Reichardt LF (1991) J Cell Biol 113(2): 405-16
    › Primary publication · 1826298 (PubMed) · PMC2288948 (PubMed Central)
  180. Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. Kurpakus MA, Quaranta V, Jones JC (1991) J Cell Biol 115(6): 1737-50
    › Primary publication · 1757471 (PubMed) · PMC2289215 (PubMed Central)
  181. MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus. Romano TA, Ridgway SH, Quaranta V (1992) J Exp Zool 263(1): 96-104
    › Primary publication · 1645122 (PubMed)
  182. An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA. Starr L, Quaranta V (1992) Biotechniques 13(4): 612-8
    › Primary publication · 1476731 (PubMed)
  183. Integrin distributions in renal cell carcinomas of various grades of malignancy. Korhonen M, Laitinen L, Ylänne J, Koukoulis GK, Quaranta V, Juusela H, Gould VE, Virtanen I (1992) Am J Pathol 141(5): 1161-71
    › Primary publication · 1443050 (PubMed) · PMC1886672 (PubMed Central)
  184. Immunolocalization of integrin alpha 6 beta 4 in mouse junctional epithelium suggests an anchoring function to both the internal and the external basal lamina. Hormia M, Virtanen I, Quaranta V (1992) J Dent Res 71(8): 1503-8
    › Primary publication · 1380525 (PubMed)
  185. [Experimental study of the anti-inflammatory action of pyrasanone in vitro]. Tursi A, Errico G, Quaranta V, Specchia G (1977) Clin Ter 83(3): 319-24
    › Primary publication · 580078 (PubMed)
  186. Serologically detectable human melanoma-associated antigens are not genetically linked to HLA-A and B antigens. Curry RA, Quaranta V, Pellegrino MA, Ferrone S (1979) J Immunol 122(6): 2630-2
    › Primary publication · 448138 (PubMed)
  187. Rosetting of human T lymphocytes with goat red blood cells: effect of treatment with 2-aminoethylisothiouronium bromide (AET) and comparison with AET treated sheep red blood cells. Indiveri F, Pellegrino MA, Molinaro GA, Quaranta V, Ferrone S (1979) J Immunol Methods 30(4): 317-28
    › Primary publication · 315972 (PubMed)
  188. A radioimmunometric antibody-binding assay for evaluation of xenoantisera to melanoma-associated antigens. McCabe RP, Quaranta V, Frugis L, Ferrone S, Reisfeld RA (1979) J Natl Cancer Inst 62(3): 455-63
    › Primary publication · 283276 (PubMed)
  189. Characterization of the specificity of DR monoclonal antibodies. Molinaro GA, Quaranta V, Ferrone S (1979) Transplant Proc 11(4): 1748-50
    › Primary publication · 93799 (PubMed)
  190. Lack of DR antigens on human B-lymphocyte-mouse fibroblast hybrids that express HLA-A,B antigens. Glassy MC, Pellegrino MA, Quaranta V, Molinaro GA, Ferrone S (1979) Transplant Proc 11(4): 1719-21
    › Primary publication · 93795 (PubMed)