Research in the Kon lab has focused on exploring connections between chronic kidney disease (CKD) and cardiovascular disease (CVD) especially on mechanisms underlying CKD-associated dysfunction in macrophage lipid handling and inflammatory function. This field has gained urgency because of strong epidemiologic evidence that individuals with any degree of renal dysfunction are at a tremendously increased risk for developing CVD. Our studies have established that even in the absence of long-standing CKD and concomitant risk factors, CKD in childhood causes specific lipoprotein abnormalities linked to maintenance of normal vascular function, including inflammatory responses in macrophages and production of adhesion molecules by endothelial cells. In more recent studies, we show that that kidneys are involved in lipoprotein homeostasis and that kidney disease modifies lipoprotein structure, composition, and function which in turn modulate cells in the renal parenchyma. We are especially interested in the role of renal lymphatic vessels which transport lipoproteins out of the interstitial compartment, and we propose are key mediators of the renal response to injury. The laboratory utilizes molecular approach, cellular physiology techniques, and genetically modified mouse models as well as rat models of renal injury to understand how lymphatic vessels affect kidney disease.
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MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term Keyword11-beta-Hydroxysteroid Dehydrogenase Type 2 Adiponectin Adiposity Apoptosis Atherosclerosis bcl-2-Associated X Protein Body Weight CKD Comorbidity Dietary Fats Disease Models, Animal Glomerular Mesangium Glomerulosclerosis, Focal Segmental HDL Hematopoietic Stem Cells HIV-1 Interleukin-2 Receptor alpha Subunit Lipoprotein Lymphatic Vessels Matrix Metalloproteinase 2 Mitogen-Activated Protein Kinase 3 Myocardial Infarction NF-kappa B Pioglitazone Podocytes Rats Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, CCR2 RNA, Messenger Thiazolidinediones Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta1 Up-Regulation Water-Electrolyte Balance