Valentina Kon
Last active: 4/2/2021

Profile

Research in the Kon lab has focused on exploring connections between chronic kidney disease (CKD) and cardiovascular disease (CVD) especially on mechanisms underlying CKD-associated dysfunction in macrophage lipid handling and inflammatory function. This field has gained urgency because of strong epidemiologic evidence that individuals with any degree of renal dysfunction are at a tremendously increased risk for developing CVD. Our studies have established that even in the absence of long-standing CKD and concomitant risk factors, CKD in childhood causes specific lipoprotein abnormalities linked to maintenance of normal vascular function, including inflammatory responses in macrophages and production of adhesion molecules by endothelial cells. In more recent studies, we show that that kidneys are involved in lipoprotein homeostasis and that kidney disease modifies lipoprotein structure, composition, and function which in turn modulate cells in the renal parenchyma. We are especially interested in the role of renal lymphatic vessels which transport lipoproteins out of the interstitial compartment, and we propose are key mediators of the renal response to injury. The laboratory utilizes molecular approach, cellular physiology techniques, and genetically modified mouse models as well as rat models of renal injury to understand how lymphatic vessels affect kidney disease.

Publications

The following timeline graph is generated from all co-authored publications.

  1. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Yamamoto S, Yancey PG, Zuo Y, Ma LJ, Kaseda R, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V (2011) Arterioscler Thromb Vasc Biol 31(12): 2856-64
    › Primary publication · 21979434 (PubMed) · PMC3227118 (PubMed Central)
  2. Podocyte injury damages other podocytes. Matsusaka T, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I (2011) J Am Soc Nephrol 22(7): 1275-85
    › Primary publication · 21719786 (PubMed) · PMC3137575 (PubMed Central)
  3. Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases. Sampson UK, Perati PR, Prins PA, Pham W, Liu Z, Harrell FE, Linton MF, Gore JC, Kon V, Fazio S (2011) J Ultrasound Med 30(6): 773-84
    › Primary publication · 21632991 (PubMed) · PMC3810347 (PubMed Central)
  4. Protective effects of PPARĪ³ agonist in acute nephrotic syndrome. Zuo Y, Yang HC, Potthoff SA, Najafian B, Kon V, Ma LJ, Fogo AB (2012) Nephrol Dial Transplant 27(1): 174-81
    › Primary publication · 21565943 (PubMed) · PMC3276311 (PubMed Central)
  5. Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside. Ma J, Matsusaka T, Yang HC, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I (2011) Pediatr Res 70(1): 83-9
    › Primary publication · 21451433 (PubMed) · PMC3113658 (PubMed Central)
  6. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Ma LJ, Corsa BA, Zhou J, Yang H, Li H, Tang YW, Babaev VR, Major AS, Linton MF, Fazio S, Hunley TE, Kon V, Fogo AB (2011) Am J Physiol Renal Physiol 300(5): F1203-13
    › Primary publication · 21367915 (PubMed) · PMC3094053 (PubMed Central)
  7. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Yamamoto S, Zuo Y, Ma J, Yancey PG, Hunley TE, Motojima M, Fogo AB, Linton MF, Fazio S, Ichikawa I, Kon V (2011) Nephrol Dial Transplant 26(8): 2491-7
    › Primary publication · 21245127 (PubMed) · PMC3203394 (PubMed Central)
  8. Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection. Matsusaka T, Kobayashi K, Kon V, Pastan I, Fogo AB, Ichikawa I (2011) Am J Physiol Renal Physiol 300(3): F792-800
    › Primary publication · 21177778 (PubMed) · PMC3064125 (PubMed Central)
  9. Atherosclerosis in chronic kidney disease: the role of macrophages. Kon V, Linton MF, Fazio S (2011) Nat Rev Nephrol 7(1): 45-54
    › Primary publication · 21102540 (PubMed) · PMC3810304 (PubMed Central)
  10. The glomerulus--a view from the inside--the endothelial cell. Fogo AB, Kon V (2010) Int J Biochem Cell Biol 42(9): 1388-97
    › Primary publication · 20541032 (PubMed)