Colleen Lawrence
Last active: 1/11/2013

Colleen Lawrence, Ph.D.

Profile

My graduate research focused on studying enzymes associated with the break down of plant material.  This research has pratical implications for the use of plant waste to generate alternative fuels such as ethanol.  As a postdoctoral fellow, I studied how lipid electrophiles such as 4-Hydroxynonenal (HNE) mediate changes in the inflammatory response.  I currently work for the Beta Cell Biology Consortium (BCBC) and am involved with data curation and scientific writing.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues. McGrath CE, Tallman KA, Porter NA, Marnett LJ (2011) Chem Res Toxicol 24(3): 357-70
    › Primary publication · 21291287 (PubMed) · PMC3062932 (PubMed Central)
  2. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M (2010) Angew Chem Int Ed Engl 49(41): 7481-5
    › Primary publication · 20814997 (PubMed) · PMC3011974 (PubMed Central)
  3. Site-directed mutagenesis to probe catalysis by a Thermobifida fusca beta-1,3-glucanase (Lam81A). McGrath CE, Vuong TV, Wilson DB (2009) Protein Eng Des Sel 22(6): 375-82
    › Primary publication · 19435780 (PubMed)
  4. Characterization of a Thermobifida fusca beta-1,3-glucanase (Lam81A) with a potential role in plant biomass degradation. McGrath CE, Wilson DB (2006) Biochemistry 45(47): 14094-100
    › Primary publication · 17115704 (PubMed)
  5. The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. Perrino FW, Blans P, Harvey S, Gelhaus SL, McGrath C, Akman SA, Jenkins GS, LaCourse WR, Fishbein JC (2003) Chem Res Toxicol 16(12): 1616-23
    › Primary publication · 14680376 (PubMed)
  6. Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz. Navamal M, McGrath C, Stewart J, Blans P, Villamena F, Zweier J, Fishbein JC (2002) J Org Chem 67(26): 9406-13
    › Citation · 12492345 (PubMed)

Featured Affiliation

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    Contact Information

    Vanderbilt University Center for Stem Cell Biology
    9465 MRB-IV
    Nashville, TN 37232
    United States
    615-875-6096 (p)
    Email

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Actinomycetales Algorithms Animals Bacterial Proteins Base Sequence Biomass Carboxymethylcellulose Sodium Catalytic Domain Diffusion DNA Adducts DNA Damage DNA Primers Electrophoresis, Polyacrylamide Gel enzymology Free Radicals Gene Expression Regulation, Neoplastic Glucan Endo-1,3-beta-D-Glucosidase HIV-1 Humans Interferon-gamma Kinetics lipid electorphiles Lipopolysaccharides microarray microscopy Mutagenesis, Insertional Oligonucleotides Plants Protein Binding Proteomics Sequence Alignment Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Structure-Activity Relationship Sulfhydryl Compounds Thymus Gland