Dan Roden, M.D.

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Publications

The following timeline graph is generated from all co-authored publications.

1. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Rasmussen-Torvik LJ, Stallings SC, Gordon AS, Almoguera B, Basford MA, Bielinski SJ, Brautbar A, Brilliant MH, Carrell DS, Connolly JJ, Crosslin DR, Doheny KF, Gallego CJ, Gottesman O, Kim DS, Leppig KA, Li R, Lin S, Manzi S, Mejia AR, Pacheco JA, Pan V, Pathak J, Perry CL, Peterson JF, Prows CA, Ralston J, Rasmussen LV, Ritchie MD, Sadhasivam S, Scott SA, Smith M, Vega A, Vinks AA, Volpi S, Wolf WA, Bottinger E, Chisholm RL, Chute CG, Haines JL, Harley JB, Keating B, Holm IA, Kullo IJ, Jarvik GP, Larson EB, Manolio T, McCarty CA, Nickerson DA, Scherer SE, Williams MS, Roden DM, Denny JC (2014) Clin Pharmacol Ther 96(4): 482-9
   › Primary publication · 24960519 (PubMed) · PMC4169732 (PubMed Central)
2. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ÅT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J, CARe Consortium, COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Polašek O, Wright AF, Griffin M, Daly MJ, DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U, eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM, HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Ärnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH, Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C (2014) Nat Genet 46(8): 826-36
   › Primary publication · 24952745 (PubMed) · PMC4124521 (PubMed Central)
3. Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations. Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC (2014) PLoS One 9(6): e100322
   › Primary publication · 24949630 (PubMed) · PMC4065041 (PubMed Central)
4. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M (2014) Clin Pharmacol Ther 96(4): 423-8
   › Primary publication · 24918167 (PubMed) · PMC4169720 (PubMed Central)
5. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM (2014) Circulation 130(3): 224-34
   › Primary publication · 24895457 (PubMed) · PMC4101031 (PubMed Central)
6. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM (2014) Clin Pharmacol Ther 96(3): 370-9
   › Primary publication · 24853734 (PubMed) · PMC4171106 (PubMed Central)
7. Biobanks and electronic medical records: enabling cost-effective research. Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM (2014) Sci Transl Med 6(234): 234cm3
   › Primary publication · 24786321 (PubMed) · PMC4226414 (PubMed Central)
8. Whole-exome sequencing in familial atrial fibrillation. Weeke P, Muhammad R, Delaney JT, Shaffer C, Mosley JD, Blair M, Short L, Stubblefield T, Roden DM, Darbar D, National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project (2014) Eur Heart J 35(36): 2477-83
   › Primary publication · 24727801 (PubMed) · PMC4169871 (PubMed Central)
9. Personalized medicine to treat arrhythmias. Roden DM (2014) Curr Opin Pharmacol : 61-7
   › Primary publication · 24721655 (PubMed) · PMC3984450 (PubMed Central)
10. Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. Jeff JM, Armstrong LL, Ritchie MD, Denny JC, Kho AN, Basford MA, Wolf WA, Pacheco JA, Li R, Chisholm RL, Roden DM, Hayes MG, Crawford DC (2014) PLoS One 9(3): e86931
    › Primary publication · 24595071 (PubMed) · PMC3940426 (PubMed Central)
11. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM (2014) J Am Coll Cardiol 63(14): 1430-7
    › Primary publication · 24561134 (PubMed) · PMC4018823 (PubMed Central)
12. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG (2014) Curr Drug Metab 15(2): 209-17
    › Primary publication · 24479687 (PubMed) · PMC3977533 (PubMed Central)
13. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM (2013) PLoS One 8(12): e81503
    › Primary publication · 24349080 (PubMed) · PMC3861317 (PubMed Central)
14. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, Rasmussen LV, Crosslin DR, Crane PK, Pathak J, Bielinski SJ, Pendergrass SA, Xu H, Hindorff LA, Li R, Manolio TA, Chute CG, Chisholm RL, Larson EB, Jarvik GP, Brilliant MH, McCarty CA, Kullo IJ, Haines JL, Crawford DC, Masys DR, Roden DM (2013) Nat Biotechnol 31(12): 1102-10
    › Primary publication · 24270849 (PubMed) · PMC3969265 (PubMed Central)
15. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Van Driest SL, Shi Y, Bowton EA, Schildcrout JS, Peterson JF, Pulley J, Denny JC, Roden DM (2014) Clin Pharmacol Ther 95(4): 423-31
    › Primary publication · 24253661 (PubMed) · PMC3961508 (PubMed Central)
16. Characterization of statin dose response in electronic medical records. Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, Wilke RA, Denny JC (2014) Clin Pharmacol Ther 95(3): 331-8
    › Primary publication · 24096969 (PubMed) · PMC3944214 (PubMed Central)
17. Genomic medicine, precision medicine, personalized medicine: what's in a name? Roden DM, Tyndale RF (2013) Clin Pharmacol Ther 94(2): 169-72
    › Primary publication · 23872826 (PubMed) · PMC3965175 (PubMed Central)
18. Relation of morbid obesity and female gender to risk of procedural complications in patients undergoing atrial fibrillation ablation. Shoemaker MB, Muhammad R, Farrell M, Parvez B, White BW, Streur M, Stubblefield T, Rytlewski J, Parvathaneni S, Nagarakanti R, Roden DM, Saavedra P, Ellis C, Whalen SP, Darbar D (2013) Am J Cardiol 111(3): 368-73
    › Primary publication · 23168290 (PubMed) · PMC3546280 (PubMed Central)
19. Cardiovascular pharmacogenomics: current status and future directions-report of a national heart, lung, and blood institute working group. Musunuru K, Roden DM, Boineau R, Bristow MR, McCaffrey TA, Newton-Cheh C, Paltoo DN, Rosenberg Y, Wohlgemuth JG, Zineh I, Hasan AA (2012) J Am Heart Assoc 1(2): e000554
    › Primary publication · 23130127 (PubMed) · PMC3487365 (PubMed Central)
20. Systems biology and cardiac arrhythmias. Grace AA, Roden DM (2012) Lancet 380(9852): 1498-508
    › Primary publication · 23101717 (PubMed) · PMC3745651 (PubMed Central)
21. Drug-induced arrhythmia: pharmacogenomic prescribing? Behr ER, Roden D (2013) Eur Heart J 34(2): 89-95
    › Primary publication · 23091201 (PubMed) · PMC3538275 (PubMed Central)
22. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Rasmussen-Torvik LJ, Pacheco JA, Wilke RA, Thompson WK, Ritchie MD, Kho AN, Muthalagu A, Hayes MG, Armstrong LL, Scheftner DA, Wilkins JT, Zuvich RL, Crosslin D, Roden DM, Denny JC, Jarvik GP, Carlson CS, Kullo IJ, Bielinski SJ, McCarty CA, Li R, Manolio TA, Crawford DC, Chisholm RL (2012) Clin Transl Sci 5(5): 394-9
    › Primary publication · 23067351 (PubMed) · PMC3521536 (PubMed Central)
23. Leveraging the electronic health record to implement genomic medicine. Kullo IJ, Jarvik GP, Manolio TA, Williams MS, Roden DM (2013) Genet Med 15(4): 270-1
    › Primary publication · 23018749 (PubMed) · PMC4206937 (PubMed Central)
24. Strategies for personalized medicine-based research and implementation in the clinical workflow. Lieb W, Völzke H, Pulley JM, Roden DM, Kroemer HK (2012) Clin Pharmacol Ther 92(4): 443-5
    › Primary publication · 22910438 (PubMed)
25. Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D (2012) J Am Coll Cardiol 60(13): 1173-81
    › Primary publication · 22818067 (PubMed) · PMC3448817 (PubMed Central)
26. The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. Behr ER, January C, Schulze-Bahr E, Grace AA, Kääb S, Fiszman M, Gathers S, Buckman S, Youssef A, Pirmohamed M, Roden D (2013) Eur Heart J 34(26): 1958-63
    › Primary publication · 22752616 (PubMed) · PMC3703308 (PubMed Central)
27. Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation. Parvez B, Vaglio J, Rowan S, Muhammad R, Kucera G, Stubblefield T, Carter S, Roden D, Darbar D (2012) J Am Coll Cardiol 60(6): 539-45
    › Primary publication · 22726630 (PubMed) · PMC3411889 (PubMed Central)
28. Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM (2012) Circ Res 111(3): 322-32
    › Primary publication · 22723299 (PubMed) · PMC3412150 (PubMed Central)
29. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER (2012) J Am Coll Cardiol 60(9): 841-50
    › Primary publication · 22682551 (PubMed) · PMC3753216 (PubMed Central)
30. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB, American Heart Association Advocacy Coordinating Committee (2012) Circulation 126(1): 142-57
    › Primary publication · 22645291 (PubMed) · PMC3721666 (PubMed Central)
31. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M, Clinical Pharmacogenomics Implementation Consortium (CPIC) (2012) Clin Pharmacol Ther 92(1): 112-7
    › Primary publication · 22617227 (PubMed) · PMC3384438 (PubMed Central)
32. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Jirjis JN, Roden DM (2012) Clin Pharmacol Ther 92(1): 87-95
    › Primary publication · 22588608 (PubMed) · PMC3581305 (PubMed Central)
33. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM (2013) Pharmacogenomics J 13(4): 325-9
    › Primary publication · 22584458 (PubMed) · PMC3422407 (PubMed Central)
34. Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM (2012) Cardiovasc Res 95(3): 300-7
    › Primary publication · 22562703 (PubMed) · PMC3633400 (PubMed Central)
35. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Delaney JT, Muhammad R, Blair MA, Kor K, Fish FA, Roden DM, Darbar D (2012) Europace 14(10): 1428-32
    › Primary publication · 22562657 (PubMed) · PMC3458578 (PubMed Central)
36. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, Smith JG, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter JI, Steinbeck G, Launer LJ, Davies RW, Borkovich M, Harris TB, Lin H, Völker U, Völzke H, Milan DJ, Hofman A, Boerwinkle E, Chen LY, Soliman EZ, Voight BF, Li G, Chakravarti A, Kubo M, Tedrow UB, Rose LM, Ridker PM, Conen D, Tsunoda T, Furukawa T, Sotoodehnia N, Xu S, Kamatani N, Levy D, Nakamura Y, Parvez B, Mahida S, Furie KL, Rosand J, Muhammad R, Psaty BM, Meitinger T, Perz S, Wichmann HE, Witteman JC, Kao WH, Kathiresan S, Roden DM, Uitterlinden AG, Rivadeneira F, McKnight B, Sjögren M, Newman AB, Liu Y, Gollob MH, Melander O, Tanaka T, Stricker BH, Felix SB, Alonso A, Darbar D, Barnard J, Chasman DI, Heckbert SR, Benjamin EJ, Gudnason V, Kääb S (2012) Nat Genet 44(6): 670-5
    › Primary publication · 22544366 (PubMed) · PMC3366038 (PubMed Central)
37. Relation of the severity of obstructive sleep apnea in response to anti-arrhythmic drugs in patients with atrial fibrillation or atrial flutter. Monahan K, Brewster J, Wang L, Parvez B, Goyal S, Roden DM, Darbar D (2012) Am J Cardiol 110(3): 369-72
    › Primary publication · 22516529 (PubMed) · PMC3398182 (PubMed Central)
38. Clopidogrel: a case for indication-specific pharmacogenetics. Johnson JA, Roden DM, Lesko LJ, Ashley E, Klein TE, Shuldiner AR (2012) Clin Pharmacol Ther 91(5): 774-6
    › Primary publication · 22513313 (PubMed) · PMC3382015 (PubMed Central)
39. Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. Delaney JT, Jeff JM, Brown NJ, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC (2012) PLoS One 7(2): e32338
    › Primary publication · 22384221 (PubMed) · PMC3285683 (PubMed Central)
40. Genetic determinants of response to cardiovascular drugs. Wells QS, Delaney JT, Roden DM (2012) Curr Opin Cardiol 27(3): 253-61
    › Primary publication · 22382501 (PubMed) · PMC3874723 (PubMed Central)
41. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2012) Pharmacogenomics 13(4): 407-18
    › Primary publication · 22329724 (PubMed) · PMC3361510 (PubMed Central)
42. A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M (2012) Circ Arrhythm Electrophysiol 5(1): 163-72
    › Primary publication · 22247482 (PubMed) · PMC4274644 (PubMed Central)
43. Modeling drug exposure data in electronic medical records: an application to warfarin. Liu M, Jiang M, Kawai VK, Stein CM, Roden DM, Denny JC, Xu H (2011) AMIA Annu Symp Proc : 815-23
    › Primary publication · 22195139 (PubMed) · PMC3243123 (PubMed Central)
44. A common β1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation. Parvez B, Chopra N, Rowan S, Vaglio JC, Muhammad R, Roden DM, Darbar D (2012) J Am Coll Cardiol 59(1): 49-56
    › Primary publication · 22192668 (PubMed) · PMC3245828 (PubMed Central)
45. Predicting clopidogrel response using DNA samples linked to an electronic health record. Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2012) Clin Pharmacol Ther 91(2): 257-63
    › Primary publication · 22190063 (PubMed) · PMC3621954 (PubMed Central)
46. Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation. Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG (2011) PLoS One 6(11): e27808
    › Primary publication · 22114699 (PubMed) · PMC3218053 (PubMed Central)
47. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, Zhang T, Stallmeyer B, Zumhagen S, Denjoy I, Bardai A, Van Gelder IC, Jamshidi Y, Dalageorgou C, Marshall V, Jeffery S, Shakir S, Camm AJ, Steinbeck G, Perz S, Lichtner P, Meitinger T, Peters A, Wichmann HE, Ingram C, Bradford Y, Carter S, Norris K, Ritchie MD, George AL, Roden DM (2012) Circ Cardiovasc Genet 5(1): 91-9
    › Primary publication · 22100668 (PubMed) · PMC3288202 (PubMed Central)
48. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M (2011) Am J Hum Genet 89(4): 529-42
    › Primary publication · 21981779 (PubMed) · PMC3188836 (PubMed Central)
49. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE (2011) PLoS One 6(9): e24593
    › Primary publication · 21980348 (PubMed) · PMC3184087 (PubMed Central)
50. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM (2011) Clin Pharmacol Ther 90(5): 674-84
    › Primary publication · 21956618 (PubMed) · PMC3329222 (PubMed Central)
51. Cardiovascular pharmacogenomics. Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A, Wilke RA (2011) Circ Res 109(7): 807-20
    › Primary publication · 21921273 (PubMed) · PMC3201825 (PubMed Central)
52. Pharmacogenomics: application to the management of cardiovascular disease. Johnson JA, Cavallari LH, Beitelshees AL, Lewis JP, Shuldiner AR, Roden DM (2011) Clin Pharmacol Ther 90(4): 519-31
    › Primary publication · 21918509 (PubMed) · PMC3190669 (PubMed Central)
53. Pharmacogenetics: call to action. Relling MV, Guchelaar HJ, Roden DM, Klein TE (2011) Clin Pharmacol Ther 90(4): 507; author reply 507-8
    › Primary publication · 21881564 (PubMed)
54. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM (2011) Circulation 124(9): 1001-11
    › Primary publication · 21824921 (PubMed) · PMC3297976 (PubMed Central)
55. Atrial fibrillation and flutter outcomes and risk determination (AFFORD): design and rationale. Barrett TW, Storrow AB, Jenkins CA, Harrell FE, Miller KF, Moser KM, Russ S, Roden DM, Darbar D (2011) J Cardiol 58(2): 124-30
    › Primary publication · 21820279 (PubMed) · PMC3169197 (PubMed Central)
56. Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy. Gong IY, Tirona RG, Schwarz UI, Crown N, Dresser GK, Larue S, Langlois N, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Carrier M, Forgie M, Wells PS, Kim RB (2011) Blood 118(11): 3163-71
    › Primary publication · 21725053 (PubMed)
57. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, Johnson JA, Roden DM, Klein TE, Shuldiner AR, Clinical Pharmacogenetics Implementation Consortium (2011) Clin Pharmacol Ther 90(2): 328-32
    › Primary publication · 21716271 (PubMed) · PMC3234301 (PubMed Central)
58. Refining repolarization reserve. Roden DM, Abraham RL (2011) Heart Rhythm 8(11): 1756-7
    › Primary publication · 21708111 (PubMed) · PMC3923504 (PubMed Central)
59. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2011) J Am Med Inform Assoc 18(4): 387-91
    › Primary publication · 21672908 (PubMed) · PMC3128409 (PubMed Central)
60. Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels. Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsao PS, Tsau PS, Kohane I, Roden DM, Altman RB (2011) Clin Pharmacol Ther 90(1): 133-42
    › Primary publication · 21613990 (PubMed) · PMC3216673 (PubMed Central)
61. The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions. Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D (2011) Clin Pharmacol Ther 89(6): 784-5
    › Primary publication · 21593754 (PubMed)
62. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. Turner SD, Berg RL, Linneman JG, Peissig PL, Crawford DC, Denny JC, Roden DM, McCarty CA, Ritchie MD, Wilke RA (2011) PLoS One 6(5): e19586
    › Primary publication · 21589926 (PubMed) · PMC3092760 (PubMed Central)
63. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM (2011) Circ Res 109(1): 38-46
    › Primary publication · 21566215 (PubMed) · PMC3135383 (PubMed Central)
64. Left atrial hypertension after repeated catheter ablations for atrial fibrillation. Shoemaker MB, Hemnes AR, Robbins IM, Langberg JJ, Ellis CR, Aznaurov SG, Fredi JL, Slosky DA, Roden DM, Murray KT, Piana RN, Mendes LA, Whalen SP (2011) J Am Coll Cardiol 57(19): 1918-9
    › Primary publication · 21545950 (PubMed)
65. Pharmacogenomics: the genetics of variable drug responses. Roden DM, Wilke RA, Kroemer HK, Stein CM (2011) Circulation 123(15): 1661-70
    › Primary publication · 21502584 (PubMed) · PMC3093198 (PubMed Central)
66. Personalized medicine and the genotype-phenotype dilemma. Roden DM (2011) J Interv Card Electrophysiol 31(1): 17-23
    › Primary publication · 21476088 (PubMed) · PMC3123434 (PubMed Central)
67. Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers. Kannankeril PJ, Norris KJ, Carter S, Roden DM (2011) Heart Rhythm 8(10): 1530-4
    › Primary publication · 21420510 (PubMed) · PMC3154568 (PubMed Central)
68. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Holm H, Gudbjartsson DF, Sulem P, Masson G, Helgadottir HT, Zanon C, Magnusson OT, Helgason A, Saemundsdottir J, Gylfason A, Stefansdottir H, Gretarsdottir S, Matthiasson SE, Thorgeirsson GM, Jonasdottir A, Sigurdsson A, Stefansson H, Werge T, Rafnar T, Kiemeney LA, Parvez B, Muhammad R, Roden DM, Darbar D, Thorleifsson G, Walters GB, Kong A, Thorsteinsdottir U, Arnar DO, Stefansson K (2011) Nat Genet 43(4): 316-20
    › Primary publication · 21378987 (PubMed) · PMC3066272 (PubMed Central)
69. Pharmacogenomics at the tipping point: challenges and opportunities. Roden DM, Tyndale RF (2011) Clin Pharmacol Ther 89(3): 323-7
    › Primary publication · 21326256 (PubMed)
70. SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study. Jeff JM, Brown-Gentry K, Buxbaum SG, Sarpong DF, Taylor HA, George AL, Roden DM, Crawford DC (2011) Circ Cardiovasc Genet 4(2): 139-44
    › Primary publication · 21325150 (PubMed) · PMC3080430 (PubMed Central)
71. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA, eMERGE Team (2011) BMC Med Genomics : 13
    › Primary publication · 21269473 (PubMed) · PMC3038887 (PubMed Central)
72. The emerging role of electronic medical records in pharmacogenomics. Wilke RA, Xu H, Denny JC, Roden DM, Krauss RM, McCarty CA, Davis RL, Skaar T, Lamba J, Savova G (2011) Clin Pharmacol Ther 89(3): 379-86
    › Primary publication · 21248726 (PubMed) · PMC3204342 (PubMed Central)
73. Genetic testing in subjects with no clinical abnormality: the tip of a huge iceberg. Roden DM (2011) J Am Coll Cardiol 57(1): 60-2
    › Primary publication · 21185502 (PubMed)
74. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Fishman GI, Chugh SS, Dimarco JP, Albert CM, Anderson ME, Bonow RO, Buxton AE, Chen PS, Estes M, Jouven X, Kwong R, Lathrop DA, Mascette AM, Nerbonne JM, O'Rourke B, Page RL, Roden DM, Rosenbaum DS, Sotoodehnia N, Trayanova NA, Zheng ZJ (2010) Circulation 122(22): 2335-48
    › Primary publication · 21147730 (PubMed) · PMC3016224 (PubMed Central)
75. Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pendergrass S, Dudek SM, Roden DM, Crawford DC, Ritchie MD (2011) Pac Symp Biocomput : 265-75
    › Primary publication · 21121054 (PubMed) · PMC3065108 (PubMed Central)
76. Pharmacogenomics: will the promise be fulfilled? Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D (2011) Nat Rev Genet 12(1): 69-73
    › Primary publication · 21116304 (PubMed) · PMC3098748 (PubMed Central)
77. Drug-induced long QT syndrome. Kannankeril P, Roden DM, Darbar D (2010) Pharmacol Rev 62(4): 760-81
    › Primary publication · 21079043 (PubMed) · PMC2993258 (PubMed Central)
78. Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds. Skinner JR, Crawford J, Smith W, Aitken A, Heaven D, Evans CA, Hayes I, Neas KR, Stables S, Koelmeyer T, Denmark L, Vuletic J, Maxwell F, White K, Yang T, Roden DM, Leren TP, Shelling A, Love DR, Cardiac Inherited Disease Group New Zealand (2011) Heart Rhythm 8(3): 412-9
    › Primary publication · 21070882 (PubMed)
79. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, Roden DM, Denny JC (2011) Heart Rhythm 8(2): 271-7
    › Primary publication · 21044898 (PubMed) · PMC3057498 (PubMed Central)
80. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg JR, Roden DM, Haines JL, Crawford DC (2010) Genet Med 12(10): 648-50
    › Primary publication · 20733501 (PubMed) · PMC2952033 (PubMed Central)
81. A clinical prediction model to estimate risk for 30-day adverse events in emergency department patients with symptomatic atrial fibrillation. Barrett TW, Martin AR, Storrow AB, Jenkins CA, Harrell FE, Russ S, Roden DM, Darbar D (2011) Ann Emerg Med 57(1): 1-12
    › Primary publication · 20728962 (PubMed) · PMC3008754 (PubMed Central)
82. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JSSG, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, Myerburg RJ, Jouven X, Kääb S, Dekker LRC, Tan HL, Tanck MWT, Wilde AAM (2010) Nat Genet 42(8): 688-691
    › Primary publication · 20622880 (PubMed) · PMC3966292 (PubMed Central)
83. Responding to the clopidogrel warning by the US food and drug administration: real life is complicated. Roden DM, Shuldiner AR (2010) Circulation 122(5): 445-8
    › Primary publication · 20585014 (PubMed) · PMC2921991 (PubMed Central)
84. Principles of human subjects protections applied in an opt-out, de-identified biobank. Pulley J, Clayton E, Bernard GR, Roden DM, Masys DR (2010) Clin Transl Sci 3(1): 42-8
    › Primary publication · 20443953 (PubMed) · PMC3075971 (PubMed Central)
85. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM (2010) Am J Hum Genet 86(4): 560-72
    › Primary publication · 20362271 (PubMed) · PMC2850440 (PubMed Central)
86. Voltage-gated sodium channels are required for heart development in zebrafish. Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM (2010) Circ Res 106(8): 1342-50
    › Primary publication · 20339120 (PubMed) · PMC2869449 (PubMed Central)
87. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, Council on Cardiovascular Nursing, American College of Cardiology Foundation (2010) J Am Coll Cardiol 55(9): 934-47
    › Primary publication · 20185054 (PubMed) · PMC3057430 (PubMed Central)
88. Common variants in KCNN3 are associated with lone atrial fibrillation. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV, Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton-Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WH, Vasan RS, Nöthen MM, MacRae CA, Stricker BH, Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V, Psaty BM, Roden DM, Meitinger T, Wichmann HE, Witteman JC, Barnard J, Arking DE, Benjamin EJ, Heckbert SR, Kääb S (2010) Nat Genet 42(3): 240-4
    › Primary publication · 20173747 (PubMed) · PMC2871387 (PubMed Central)
89. KCNH2 pharmacogenomics summary. Oshiro C, Thorn CF, Roden DM, Klein TE, Altman RB (2010) Pharmacogenet Genomics 20(12): 775-7
    › Primary publication · 20150828 (PubMed) · PMC3086352 (PubMed Central)
90. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the American College of Cardiology Foundation (2010) Circulation 121(8): 1047-60
    › Primary publication · 20142454 (PubMed) · PMC3056123 (PubMed Central)
91. Brugada syndrome: lots of questions, some answers. Roden DM (2010) Heart Rhythm 7(1): 47-9
    › Primary publication · 20129284 (PubMed)
92. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D (2009) Circ Cardiovasc Genet 2(5): 499-506
    › Primary publication · 20031626 (PubMed) · PMC2801871 (PubMed Central)
93. Arrhythmia pharmacogenomics: methodological considerations. Roden DM, Kannankeri PJ, Darbar D (2009) Curr Pharm Des 15(32): 3734-41
    › Primary publication · 19925424 (PubMed) · PMC2788624 (PubMed Central)
94. Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome. Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI (2009) Circ Arrhythm Electrophysiol 2(4): 417-26
    › Primary publication · 19808498 (PubMed) · PMC2748886 (PubMed Central)
95. Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM (2009) Circ Arrhythm Electrophysiol 2(3): 268-75
    › Primary publication · 19808477 (PubMed) · PMC2727725 (PubMed Central)
96. Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study. Watanabe H, Watanabe T, Sasaki S, Nagai K, Roden DM, Aizawa Y (2009) Am Heart J 158(4): 629-36
    › Primary publication · 19781424 (PubMed)
97. Cardiovascular effects of noncardiovascular drugs. Raj SR, Stein CM, Saavedra PJ, Roden DM (2009) Circulation 120(12): 1123-32
    › Primary publication · 19770411 (PubMed) · PMC2773827 (PubMed Central)
98. Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, Wilde AA (2009) Heart Rhythm 6(9): 1335-41
    › Primary publication · 19716089 (PubMed) · PMC2779019 (PubMed Central)
99. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA (2009) Circulation 120(7): 553-9
    › Primary publication · 19652097 (PubMed) · PMC2771327 (PubMed Central)
100. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D (2009) Heart Rhythm 6(9): 1327-32
     › Primary publication · 19648063 (PubMed) · PMC2740737 (PubMed Central)
101. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K (2009) Nat Genet 41(8): 876-8
     › Primary publication · 19597491 (PubMed) · PMC2740741 (PubMed Central)
102. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD (2009) Pharmacogenomics 10(6): 1043-53
     › Primary publication · 19530973 (PubMed) · PMC2746955 (PubMed Central)
103. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM (2009) J Cardiovasc Pharmacol 54(1): 63-71
     › Primary publication · 19528813 (PubMed) · PMC3745652 (PubMed Central)
104. Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation. Yang T, Kanki H, Zhang W, Roden DM (2009) Br J Pharmacol 157(6): 952-61
     › Primary publication · 19522859 (PubMed) · PMC2737654 (PubMed Central)
105. Clopidogrel and the concept of high-risk pharmacokinetics. Roden DM, Stein CM (2009) Circulation 119(16): 2127-30
     › Primary publication · 19398674 (PubMed)
106. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC (2009) Nat Med 15(4): 380-3
     › Primary publication · 19330009 (PubMed) · PMC2904954 (PubMed Central)
107. A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation. Husser D, Stridh M, Sörnmo L, Roden DM, Darbar D, Bollmann A (2009) Circ Arrhythm Electrophysiol 2(1): 24-8
     › Primary publication · 19305639 (PubMed) · PMC2658819 (PubMed Central)
108. Estimation of the warfarin dose with clinical and pharmacogenetic data. International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA (2009) N Engl J Med 360(8): 753-64
     › Primary publication · 19228618 (PubMed) · PMC2722908 (PubMed Central)
109. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT (2009) Eur Heart J 30(7): 813-9
     › Primary publication · 19141561 (PubMed) · PMC2663727 (PubMed Central)
110. Repolarization reserve: a moving target. Roden DM (2008) Circulation 118(10): 981-2
     › Primary publication · 18765386 (PubMed)

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