Our research is focused on Sonic hedgehog (Shh) signaling in development and cancer. We study how Shh protein distribution and signaling are regulated and how this regulation affects the identity and number of neural progenitors/stem cells in the central nervous system. We use stem cell cultures and mouse genetics to address these crucial questions, with emphasis on 1) neural stem cells/progenitors involved in the establishment of the brain circuitry and 2) tumor stem cells in the initiation and progression of pediatric tumors.
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MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordApoptosis brain circuitry brain tumors cancer Cell Lineage central nervous system Cilia Culture Media, Serum-Free development Disease Models, Animal Endoderm Extracellular Signal-Regulated MAP Kinases Fetus Fibroblast Growth Factor 8 Flow Cytometry Gene Expression Regulation, Neoplastic Hippocampus Homeodomain Proteins Humans LIM-Homeodomain Proteins Lymphocytes MAP Kinase Kinase Kinases medulloblastoma Mutation Myelin Sheath neural progenitors neural progenitors/stem cells Neurons Oxazoles Rahbdomyosarcoma Rats Receptors, Cell Surface Resting Phase, Cell Cycle RNA, Messenger Sarcoma Sarcoma Sonic hedgehog Stress, Physiological Trachea Tracheal Diseases Transplantation, Heterologous tumor stem cells Up-Regulation