Chin Chiang
Professor of Cell and Developmental Biol
Last active: 7/23/2021


Our research is focused on Sonic hedgehog (Shh) signaling in development and cancer. We study how Shh protein distribution and signaling are regulated and how this regulation affects the identity and number of neural progenitors/stem cells in the central nervous system. We use stem cell cultures and mouse genetics to address these crucial questions, with emphasis on 1) neural stem cells/progenitors involved in the establishment of the brain circuitry and 2) tumor stem cells in the initiation and progression of pediatric tumors.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model. Fleming JT, Brignola E, Chen L, Guo Y, Zhao S, Wang Q, Li B, Correa H, Ermilov AN, Dlugosz AA, Chiang C (2019) Mol Cancer Res 17(5): 1024-1035
    › Primary publication · 30683671 (PubMed) · PMC6497566 (PubMed Central)
  2. Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Cheng FY, Fleming JT, Chiang C (2018) Dev Biol 440(2): 152-166
    › Primary publication · 29792854 (PubMed) · PMC6014626 (PubMed Central)
  3. Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex. Ryan KE, Kim PS, Fleming JT, Brignola E, Cheng FY, Litingtung Y, Chiang C (2017) Dev Biol 432(1): 165-177
    › Primary publication · 28974424 (PubMed) · PMC5694378 (PubMed Central)
  4. The Purkinje neuron: A central orchestrator of cerebellar neurogenesis. Fleming J, Chiang C (2015) Neurogenesis (Austin) 2(1): e1025940
    › Primary publication · 27604220 (PubMed) · PMC4973588 (PubMed Central)
  5. BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J (2016) Oncotarget 7(28): 43504-43517
    › Primary publication · 27259270 (PubMed) · PMC5190040 (PubMed Central)
  6. Consensus Paper: Cerebellar Development. Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerkov√° G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R (2016) Cerebellum 15(6): 789-828
    › Primary publication · 26439486 (PubMed) · PMC4846577 (PubMed Central)
  7. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC (2015) Cell Rep 11(1): 43-50
    › Primary publication · 25818300 (PubMed) · PMC4394042 (PubMed Central)
  8. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression. Chiang C, Ihrie RA (2014) Cancer Cell 26(6): 773-774
    › Primary publication · 25490438 (PubMed)