Hak-Joon Sung
Assistant Professor of Biomedical Engineering, Assistant Professor of Medicine-Cardiovascular Medicine
Last active: 2/12/2015


Dr. Sung Joined Vanderbilt University as an assistant professor of Biomedical Engineering in 2009. He was a resident faculty member at the New Jersey Center for Biomaterials, Rutgers University from 2006 to 2009.  He conducted his postdoctoral and graduate studies at Georgia Institute of Technology (joint program with Emory University School of Medicine) from 2001 to 2006. He had previous master degree training in Medical Engineering and undergraduate training in Biochemistry at Yonsei University in South Korea.  His current research is focused on application of advanced combinatorial biomaterial systems for stem cell and vascular engineering.   


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response. Lee SH, Boire TC, Lee JB, Gupta MK, Zachman AL, Rath R, Sung HJ (2014) J Mater Chem B 2(41): 7109-7113
    › Primary publication · 25343029 (PubMed) · PMC4203664 (PubMed Central)
  2. Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ (2014) Biomaterials 35(36): 9635-48
    › Primary publication · 25154665 (PubMed) · PMC4164579 (PubMed Central)
  3. Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications. Lee SH, Gupta MK, Bang JB, Bae H, Sung HJ (2013) Adv Healthc Mater 2(6): 908-15
    › Primary publication · 25136729 (PubMed) · PMC4146500 (PubMed Central)
  4. Polymeric stent materials dysregulate macrophage and endothelial cell functions: implications for coronary artery stent. Wang X, Zachman AL, Chun YW, Shen FW, Hwang YS, Sung HJ (2014) Int J Cardiol 174(3): 688-95
    › Primary publication · 24820736 (PubMed) · PMC4070878 (PubMed Central)
  5. Combined usage of stem cells in end-stage heart failure therapies. Wang X, Zachman AL, Haglund NA, Maltais S, Sung HJ (2014) J Cell Biochem 115(7): 1217-24
    › Primary publication · 24753018 (PubMed)
  6. Therapeutic application of nanotechnology in cardiovascular and pulmonary regeneration. Chun YW, Crowder SW, Mehl SC, Wang X, Bae H, Sung HJ (2013) Comput Struct Biotechnol J : e201304005
    › Primary publication · 24688735 (PubMed) · PMC3962146 (PubMed Central)
  7. Cancer Stem Cells under Hypoxia as a Chemoresistance Factor in Breast and Brain. Crowder SW, Balikov DA, Hwang YS, Sung HJ (2014) Curr Pathobiol Rep 2(1): 33-40
    › Primary publication · 24587979 (PubMed) · PMC3935368 (PubMed Central)
  8. Neurovascular unit on a chip: implications for translational applications. Alcendor DJ, Block FE, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP (2013) Stem Cell Res Ther : S18
    › Primary publication · 24564885 (PubMed) · PMC4029462 (PubMed Central)
  9. Femtosecond laser-patterned nanopore arrays for surface-mediated peptide treatment. Zachman AL, Hofmeister LH, Costa L, Boire TC, Hwang YS, Hofmeister WH, Sung HJ (2014) Nanomedicine 10(1): 11-4
    › Primary publication · 24090768 (PubMed) · PMC3877160 (PubMed Central)
  10. Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells. Crowder SW, Prasai D, Rath R, Balikov DA, Bae H, Bolotin KI, Sung HJ (2013) Nanoscale 5(10): 4171-6
    › Primary publication · 23592029 (PubMed) · PMC3672224 (PubMed Central)
  11. Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia. Crowder SW, Horton LW, Lee SH, McClain CM, Hawkins OE, Palmer AM, Bae H, Richmond A, Sung HJ (2013) FASEB J 27(7): 2788-98
    › Primary publication · 23568779 (PubMed) · PMC3688746 (PubMed Central)
  12. Poly(ε-caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells. Crowder SW, Liang Y, Rath R, Park AM, Maltais S, Pintauro PN, Hofmeister W, Lim CC, Wang X, Sung HJ (2013) Nanomedicine (Lond) 8(11): 1763-76
    › Primary publication · 23530764 (PubMed) · PMC3809159 (PubMed Central)
  13. Stem cell therapy for chronic heart failure: an updated appraisal. Maltais S, Joggerst SJ, Hatzopoulos A, DiSalvo TG, Zhao D, Sung HJ, Wang X, Byrne JG, Naftilan AJ (2013) Expert Opin Biol Ther 13(4): 503-16
    › Primary publication · 23289619 (PubMed) · PMC4928684 (PubMed Central)
  14. Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films. Zachman AL, Page JM, Prabhakar G, Guelcher SA, Sung HJ (2013) Acta Biomater 9(2): 4964-75
    › Primary publication · 23128157 (PubMed) · PMC3606556 (PubMed Central)
  15. Cell interaction study method using novel 3D silica nanoneedle gradient arrays. Rajput D, Crowder SW, Hofmeister L, Costa L, Sung HJ, Hofmeister W (2013) Colloids Surf B Biointerfaces : 111-6
    › Primary publication · 23006558 (PubMed) · PMC3513632 (PubMed Central)
  16. UV laser-ablated surface textures as potential regulator of cellular response. Chandra P, Lai K, Sung HJ, Murthy NS, Kohn J (2010) Biointerphases 5(2): 53-9
    › Primary publication · 20831349 (PubMed)
  17. Interplay of anionic charge, poly(ethylene glycol), and iodinated tyrosine incorporation within tyrosine-derived polycarbonates: Effects on vascular smooth muscle cell adhesion, proliferation, and motility. Johnson PA, Luk A, Demtchouk A, Patel H, Sung HJ, Treiser MD, Gordonov S, Sheihet L, Bolikal D, Kohn J, Moghe PV (2010) J Biomed Mater Res A 93(2): 505-14
    › Primary publication · 19585568 (PubMed) · PMC2845728 (PubMed Central)
  18. High-content profiling of cell responsiveness to graded substrates based on combinyatorially variant polymers. Liu E, Treiser MD, Patel H, Sung HJ, Roskov KE, Kohn J, Becker ML, Moghe PV (2009) Comb Chem High Throughput Screen 12(7): 646-55
    › Primary publication · 19531022 (PubMed) · PMC3061568 (PubMed Central)
  19. Synthetic polymeric substrates as potent pro-oxidant versus anti-oxidant regulators of cytoskeletal remodeling and cell apoptosis. Sung HJ, Chandra P, Treiser MD, Liu E, Iovine CP, Moghe PV, Kohn J (2009) J Cell Physiol 218(3): 549-57
    › Primary publication · 19016472 (PubMed)
  20. Profiling cell-biomaterial interactions via cell-based fluororeporter imaging. Treiser MD, Liu E, Dubin RA, Sung HJ, Kohn J, Moghe PV (2007) Biotechniques 43(3): 361-6, 368
    › Primary publication · 17907579 (PubMed)
  21. Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types. Sung HJ, Yee A, Eskin SG, McIntire LV (2007) Am J Physiol Cell Physiol 293(1): C87-94
    › Primary publication · 17314265 (PubMed)
  22. Oxidative stress produced with cell migration increases synthetic phenotype of vascular smooth muscle cells. Sung HJ, Eskin SG, Sakurai Y, Yee A, Kataoka N, McIntire LV (2005) Ann Biomed Eng 33(11): 1546-54
    › Primary publication · 16341922 (PubMed)
  23. In vitro bioassay of endotoxin using fluorescein as a pH indicator in a macrophage cell culture system. Lee DH, Sung HJ, Han DW, Lee MS, Ryu GH, Aihara M, Takatori K, Park JC (2005) Yonsei Med J 46(2): 268-74
    › Primary publication · 15861501 (PubMed) · PMC2823024 (PubMed Central)
  24. Matrix metalloproteinase 9 facilitates collagen remodeling and angiogenesis for vascular constructs. Sung HJ, Johnson CE, Lessner SM, Magid R, Drury DN, Galis ZS (2005) Tissue Eng 11(1-2): 267-76
    › Primary publication · 15738681 (PubMed)
  25. The use of temperature-composition combinatorial libraries to study the effects of biodegradable polymer blend surfaces on vascular cells. Sung HJ, Su J, Berglund JD, Russ BV, Meredith JC, Galis ZS (2005) Biomaterials 26(22): 4557-67
    › Primary publication · 15722125 (PubMed)
  26. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Sung HJ, Meredith C, Johnson C, Galis ZS (2004) Biomaterials 25(26): 5735-42
    › Primary publication · 15147819 (PubMed)
  27. Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Khatri JJ, Johnson C, Magid R, Lessner SM, Laude KM, Dikalov SI, Harrison DG, Sung HJ, Rong Y, Galis ZS (2004) Circulation 109(4): 520-5
    › Primary publication · 14744973 (PubMed)
  28. Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Johnson C, Sung HJ, Lessner SM, Fini ME, Galis ZS (2004) Circ Res 94(2): 262-8
    › Primary publication · 14670843 (PubMed) · PMC6716372 (PubMed Central)
  29. Liposomal entrapment of cefoxitin to improve cellular viability and function in human saphenous veins. Park JC, Suh H, Sung HJ, Han DW, Lee DH, Park BJ, Park YH, Cho BK (2003) Artif Organs 27(7): 623-30
    › Primary publication · 12823417 (PubMed)

Featured Affiliation

  • Sung Lab
    Assistant Professor of Biomedical Engineering, Assistant Professor of Medicine-Cardiovascular Medicine
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Contact Information

Department of Biomedical Engineering
Stevenson Center #5921
Nashville, TN 37235-1631
United States
615-322-6986 (p)
615-343-7919 (f)

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Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

and Tissue Engineering Biological Assay Cell- and Tissue-Based Therapy Cell Adhesion Cell Death Cell Physiological Phenomena Combinatorial Biomaterials and Biointerface Coronary Artery Bypass Culture Media Cytoskeleton Engineering Aspect of Cardiovascular Medicine Fibroblasts Graphite Heart Intracellular Space In Vitro Techniques Materials Testing Matrix Metalloproteinase 9 Matrix Metalloproteinase Inhibitors Mice, Inbred Strains Molecular Structure Myocytes, Smooth Muscle Myosin Heavy Chains Neovascularization, Pathologic Neovascularization, Physiologic Organoselenium Compounds Peptides Peripheral Arterial Disease Peroxides Phosphoproteins Silicon Dioxide Stem Cell Engineering Sterilization Tumor Suppressor Protein p53