Judsen Schneider
Last active: 6/29/2012

Profile

 

My interest in diabetes began in college.  Here, I had two externship opportunities at Baptist Hospital, in Nashville, TN with a Hospitalist/Critical Care service, gathering statistics on the readmission rate (return for the same diagnosis) and overall quality of care for diabetic patients.  Having had extensive contact with patients themselves I saw the struggle that these patients undergo on a daily basis.  After graduating from college in 2003, I became a technician in the laboratory of Christopher Ferris, MD, PhD.  Here, I worked on developing a treatment for diabetic gastroparesis, a late-stage disorder that limits the transit of food from the stomach through the pylorus. 

I decided to go to graduate school and joined Vanderbilt's IGP program in 2004.  As a graduate student, I worked in the laboratory of David Miller, Ph.D. studying a basic question in neurobiology:  How do neurons choose appropriate synaptic partners?  We used a tiny nematode, C. elegans for these studies due to its simplistic and well-characterized nervous system.  Here, we identified that the transcription factor, unc-4, regulates synaptic specificity in one subtype of motor neuron, by altering sensitivity to the morphogen Wnt.   After receiving my Ph.D. in December 2009, I did a short post-doc with David Miller.   

I returned to the field of diabetes by joining Mark Magnuson's lab in May 2010.  My research interests include the development and differentiation of pancreatic progenitor cells and adult/embryonic stem cell differentiation.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Schneider J, Skelton RL, Von Stetina SE, Middelkoop TC, van Oudenaarden A, Korswagen HC, Miller DM (2012) Development 139(12): 2234-45
    › Primary publication · 22619391 (PubMed) · PMC3357913 (PubMed Central)
  2. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E (2010) Nat Chem Biol 6(11): 829-36
    › Primary publication · 20890287 (PubMed) · PMC3681608 (PubMed Central)