Profile

I completed my graduate studies in molecular virology followed by postdoctoral training in mouse functional genomics, in particular, genome wide mutagenesis by gene entrapment.  My initial research was focused on development of new replaceable poly (A) trap gene trap strategies that would allow genes disrupted in individual ES cell clones to be engineered by Cre-mediated recombination to allow post-entrapment modifications of the locus.  Later on, I worked on functional characterization of mice with gene trap mutations in dymectin (Dym) and Ttc18 genes.  We established Dym as a novel vesicular traffic gene which, when mutated, is responsible for chondrodysplasia in mice and men.  We also showed that Ttc18 is evolutionary conserved gene involved in motile cilia function and primary ciliary diskinesia pathogenesis

 

 

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA (2017) Diabetes
    › Primary publication · 28550109 (PubMed)
  2. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Osipovich AB, Gangula R, Vianna PG, Magnuson MA (2016) Development 143(24): 4595-4607
    › Primary publication · 27864380 (PubMed)
  3. Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming. Clayton HW, Osipovich AB, Stancill JS, Schneider JD, Vianna PG, Shanks CM, Yuan W, Gu G, Manduchi E, Stoeckert CJ, Magnuson MA (2016) Cell Rep 17(8): 2028-2041
    › Primary publication · 27851966 (PubMed) · PMC5131369 (PubMed Central)
  4. Insm1 promotes neurogenic proliferation in delaminated otic progenitors. Lorenzen SM, Duggan A, Osipovich AB, Magnuson MA, García-Añoveros J (2015) Mech Dev : 233-45
    › Primary publication · 26545349 (PubMed) · PMC4679445 (PubMed Central)
  5. Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M (2015) Diabetes 64(11): 3829-38
    › Primary publication · 26251404 (PubMed) · PMC4613976 (PubMed Central)
  6. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Brouwers B, de Faudeur G, Osipovich AB, Goyvaerts L, Lemaire K, Boesmans L, Cauwelier EJ, Granvik M, Pruniau VP, Van Lommel L, Van Schoors J, Stancill JS, Smolders I, Goffin V, Binart N, in't Veld P, Declercq J, Magnuson MA, Creemers JW, Schuit F, Schraenen A (2014) Cell Metab 20(6): 979-90
    › Citation · 25470546 (PubMed)
  7. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ, Takada S, Magnuson MA (2014) Development 141(15): 2939-49
    › Primary publication · 25053427 (PubMed) · PMC4197673 (PubMed Central)
  8. Pancreas-specific Cre driver lines and considerations for their prudent use. Magnuson MA, Osipovich AB (2013) Cell Metab 18(1): 9-20
    › Primary publication · 23823474 (PubMed) · PMC3732107 (PubMed Central)
  9. Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Chen SX, Osipovich AB, Ustione A, Potter LA, Hipkens S, Gangula R, Yuan W, Piston DW, Magnuson MA (2011) Dis Model Mech 4(4): 537-47
    › Primary publication · 21324933 (PubMed) · PMC3124063 (PubMed Central)
  10. Dyggve-Melchior-Clausen syndrome: chondrodysplasia resulting from defects in intracellular vesicle traffic. Osipovich AB, Jennings JL, Lin Q, Link AJ, Ruley HE (2008) Proc Natl Acad Sci U S A 105(42): 16171-6
    › Primary publication · 18852472 (PubMed) · PMC2571016 (PubMed Central)
  11. Subunit 1 of the prefoldin chaperone complex is required for lymphocyte development and function. Cao S, Carlesso G, Osipovich AB, Llanes J, Lin Q, Hoek KL, Khan WN, Ruley HE (2008) J Immunol 181(1): 476-84
    › Primary publication · 18566413 (PubMed)
  12. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, Donahue SL, Moore-Jarrett T, Cao S, Osipovich AB, Ruley HE (2006) Nucleic Acids Res 34(20): e139
    › Primary publication · 17062627 (PubMed) · PMC1635309 (PubMed Central)
  13. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, Singh A, Ruley HE (2005) Genome Res 15(3): 428-35
    › Primary publication · 15741512 (PubMed) · PMC551569 (PubMed Central)
  14. Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment. Osipovich AB, White-Grindley EK, Hicks GG, Roshon MJ, Shaffer C, Moore JH, Ruley HE (2004) Nucleic Acids Res 32(9): 2912-24
    › Primary publication · 15155860 (PubMed) · PMC419606 (PubMed Central)