Aaron Bowman
Associate Professor, Pediatrics, Neurology and Biochemistry
Last active: 4/11/2018


Gene-environment interactions underlying neurological and neurodevelopment disorders.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells. Dos Santos AA, López-Granero C, Farina M, Rocha JBT, Bowman AB, Aschner M (2018) Food Chem Toxicol : 328-336
    › Primary publication · 29428217 (PubMed)
  2. Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming. Armstrong LC, Westlake G, Snow JP, Cawthon B, Armour E, Bowman AB, Ess KC (2017) Hum Mol Genet 26(23): 4629-4641
    › Primary publication · 28973543 (PubMed) · PMC5886307 (PubMed Central)
  3. From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Neely MD, Davison CA, Aschner M, Bowman AB (2017) Toxicol Sci 159(2): 366-379
    › Primary publication · 28962525 (PubMed) · PMC5837701 (PubMed Central)
  4. Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders. Bryan MR, Bowman AB (2017) Adv Neurobiol : 113-142
    › Primary publication · 28889265 (PubMed) · PMC6559248 (PubMed Central)
  5. Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line. Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB (2018) Neurotoxicology : 185-194
    › Primary publication · 28780388 (PubMed) · PMC5796869 (PubMed Central)
  6. Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease. Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V (2017) Sci Rep 7(1): 5280
    › Primary publication · 28706199 (PubMed) · PMC5509685 (PubMed Central)
  7. Phenotypic Discordance in Siblings with Identical Compound Heterozygous PARK2 Mutations. Isaacs D, Claassen D, Bowman AB, Hedera P (2017) Brain Sci 7(7)
    › Primary publication · 28672806 (PubMed) · PMC5532584 (PubMed Central)
  8. Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease. Pfalzer AC, Bowman AB (2017) Curr Environ Health Rep 4(2): 223-228
    › Primary publication · 28417441 (PubMed) · PMC5515274 (PubMed Central)
  9. Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells. Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, Lippmann ES (2017) Fluids Barriers CNS 14(1): 9
    › Primary publication · 28407791 (PubMed) · PMC5390351 (PubMed Central)
  10. BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia. López-Granero C, Antunes Dos Santos A, Ferrer B, Culbreth M, Chakraborty S, Barrasa A, Gulinello M, Bowman AB, Aschner M (2017) Psychoneuroendocrinology : 92-98
    › Primary publication · 28324704 (PubMed) · PMC5985819 (PubMed Central)
  11. Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model. Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB (2017) Biochim Biophys Acta Mol Basis Dis 1863(6): 1596-1604
    › Primary publication · 28213125 (PubMed) · PMC5515276 (PubMed Central)
  12. Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP (2016) J Neuroinflammation 13(1): 306
    › Primary publication · 27955696 (PubMed) · PMC5153753 (PubMed Central)
  13. Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease. Osmand AP, Bichell TJ, Bowman AB, Bates GP (2016) J Huntingtons Dis 5(4): 343-346
    › Primary publication · 27886014 (PubMed) · PMC5181660 (PubMed Central)
  14. "Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies". Peres TV, Schettinger MR, Chen P, Carvalho F, Avila DS, Bowman AB, Aschner M (2016) BMC Pharmacol Toxicol 17(1): 57
    › Primary publication · 27814772 (PubMed) · PMC5097420 (PubMed Central)
  15. Sex- and structure-specific differences in antioxidant responses to methylmercury during early development. Ruszkiewicz JA, Bowman AB, Farina M, Rocha JBT, Aschner M (2016) Neurotoxicology : 118-126
    › Primary publication · 27456245 (PubMed) · PMC5991801 (PubMed Central)
  16. Linear and Curvilinear Trajectories of Cortical Loss with Advancing Age and Disease Duration in Parkinson's Disease. Claassen DO, Dobolyi DG, Isaacs DA, Roman OC, Herb J, Wylie SA, Neimat JS, Donahue MJ, Hedera P, Zald DH, Landman BA, Bowman AB, Dawant BM, Rane S (2016) Aging Dis 7(3): 220-9
    › Primary publication · 27330836 (PubMed) · PMC4898918 (PubMed Central)
  17. Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Bryan MR, Aschner M, Ess KC, Bowman AB (2016) PLoS One 11(3): e0150372
    › Primary publication · 26982737 (PubMed) · PMC4794230 (PubMed Central)
  18. Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, Wikswo JP (2015) Biomicrofluidics 9(5): 054124
    › Primary publication · 26576206 (PubMed) · PMC4627929 (PubMed Central)
  19. Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice. Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ (2015) Proc Natl Acad Sci U S A 112(45): 14078-83
    › Primary publication · 26508634 (PubMed) · PMC4653197 (PubMed Central)
  20. SLC30A10: A novel manganese transporter. Chen P, Bowman AB, Mukhopadhyay S, Aschner M (2015) Worm 4(3): e1042648
    › Primary publication · 26430566 (PubMed) · PMC4588552 (PubMed Central)
  21. Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype. Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB (2015) J Huntingtons Dis 4(1): 17-36
    › Primary publication · 26333255 (PubMed) · PMC4657874 (PubMed Central)
  22. RNASeq in C. elegans Following Manganese Exposure. Parmalee NL, Maqbool SB, Ye B, Calder B, Bowman AB, Aschner M (2015) Curr Protoc Toxicol : 11.20.1-11.20.17
    › Primary publication · 26250396 (PubMed) · PMC4539565 (PubMed Central)
  23. Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes. Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC (2015) Biomaterials : 52-64
    › Primary publication · 26204225 (PubMed) · PMC4550551 (PubMed Central)
  24. Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. Kwakye GF, Paoliello MM, Mukhopadhyay S, Bowman AB, Aschner M (2015) Int J Environ Res Public Health 12(7): 7519-40
    › Primary publication · 26154659 (PubMed) · PMC4515672 (PubMed Central)
  25. Manganese homeostasis in the nervous system. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M (2015) J Neurochem 134(4): 601-10
    › Primary publication · 25982296 (PubMed) · PMC4516557 (PubMed Central)
  26. Manganese Is Essential for Neuronal Health. Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M (2015) Annu Rev Nutr : 71-108
    › Primary publication · 25974698 (PubMed) · PMC6525788 (PubMed Central)
  27. Manganese-induced Neurotoxicity: From to Humans. Chen P, Chakraborty S, Peres TV, Bowman AB, Aschner M (2015) Toxicol Res (Camb) 4(2): 191-202
    › Primary publication · 25893090 (PubMed) · PMC4399965 (PubMed Central)
  28. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, Bowman AB, Aschner M (2015) Metallomics 7(5): 847-56
    › Primary publication · 25769119 (PubMed) · PMC4431931 (PubMed Central)
  29. Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB (2015) Metallomics 7(2): 363-70
    › Primary publication · 25599126 (PubMed) · PMC4326616 (PubMed Central)
  30. Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease. Chen P, DeWitt MR, Bornhorst J, Soares FA, Mukhopadhyay S, Bowman AB, Aschner M (2015) Metallomics 7(2): 289-98
    › Primary publication · 25531510 (PubMed) · PMC4479152 (PubMed Central)
  31. A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease. Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB (2015) Hum Mol Genet 24(7): 1929-44
    › Primary publication · 25489053 (PubMed) · PMC4355025 (PubMed Central)
  32. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB (2014) Sci Rep : 6801
    › Primary publication · 25348053 (PubMed) · PMC4210885 (PubMed Central)
  33. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S (2014) J Neurosci 34(42): 14079-95
    › Primary publication · 25319704 (PubMed) · PMC4198546 (PubMed Central)
  34. PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB (2015) Neurobiol Dis : 204-12
    › Primary publication · 25315681 (PubMed) · PMC4394022 (PubMed Central)
  35. BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity. Stansfield KH, Bichell TJ, Bowman AB, Guilarte TR (2014) J Neurochem 131(5): 655-66
    › Primary publication · 25099302 (PubMed) · PMC4296578 (PubMed Central)
  36. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM (2014) Am J Physiol Cell Physiol 307(5): C415-30
    › Primary publication · 24871858 (PubMed) · PMC4154073 (PubMed Central)
  37. Considerations on manganese (Mn) treatments for in vitro studies. Bowman AB, Aschner M (2014) Neurotoxicology : 141-2
    › Primary publication · 24509086 (PubMed) · PMC4004588 (PubMed Central)
  38. Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation. Srinivasakumar N, Zaboikin M, Tidball AM, Aboud AA, Neely MD, Ess KC, Bowman AB, Schuening FG (2013) PeerJ : e224
    › Primary publication · 24392288 (PubMed) · PMC3869187 (PubMed Central)
  39. Optimization of fluorescence assay of cellular manganese status for high throughput screening. Kumar KK, Aboud AA, Patel DK, Aschner M, Bowman AB (2013) J Biochem Mol Toxicol 27(1): 42-9
    › Primary publication · 23169769 (PubMed) · PMC3774111 (PubMed Central)
  40. Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects. Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB (2012) Neurotoxicology 33(6): 1443-1449
    › Primary publication · 23099318 (PubMed) · PMC3518601 (PubMed Central)
  41. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB (2012) ACS Chem Neurosci 3(6): 482-91
    › Primary publication · 22860217 (PubMed) · PMC3400384 (PubMed Central)
  42. Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism. Madison JL, Wegrzynowicz M, Aschner M, Bowman AB (2012) PLoS One 7(2): e31024
    › Primary publication · 22363539 (PubMed) · PMC3281892 (PubMed Central)
  43. The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Kumar KK, Aboud AA, Bowman AB (2012) Neurotoxicology 33(3): 518-29
    › Primary publication · 22330734 (PubMed) · PMC3358591 (PubMed Central)
  44. Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese. Wegrzynowicz M, Holt HK, Friedman DB, Bowman AB (2012) J Proteome Res 11(2): 1118-32
    › Primary publication · 22191580 (PubMed) · PMC3319668 (PubMed Central)
  45. DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z (2012) Neurobiol Dis 45(3): 923-9
    › Primary publication · 22182693 (PubMed) · PMC3674775 (PubMed Central)
  46. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY (2011) Dev Cell 21(4): 746-57
    › Primary publication · 22014525 (PubMed) · PMC3253850 (PubMed Central)
  47. Role of manganese in neurodegenerative diseases. Bowman AB, Kwakye GF, Herrero Hernández E, Aschner M (2011) J Trace Elem Med Biol 25(4): 191-203
    › Primary publication · 21963226 (PubMed) · PMC3230726 (PubMed Central)
  48. Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response. Grover VK, Valadez JG, Bowman AB, Cooper MK (2011) PLoS One 6(7): e21353
    › Primary publication · 21747935 (PubMed) · PMC3128587 (PubMed Central)
  49. Gender and manganese exposure interactions on mouse striatal neuron morphology. Madison JL, Wegrzynowicz M, Aschner M, Bowman AB (2011) Neurotoxicology 32(6): 896-906
    › Primary publication · 21641932 (PubMed) · PMC3169725 (PubMed Central)
  50. Cellular fura-2 manganese extraction assay (CFMEA). Kwakye GF, Li D, Kabobel OA, Bowman AB (2011) Curr Protoc Toxicol : Unit12.18
    › Primary publication · 21553393 (PubMed) · PMC3661216 (PubMed Central)
  51. Role of astrocytes in brain function and disease. Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M (2011) Toxicol Pathol 39(1): 115-23
    › Primary publication · 21075920 (PubMed) · PMC6218934 (PubMed Central)