Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Zhang B, Beeghly-Fadiel A, Long J, Zheng W (2011) Lancet Oncol 12: 477-88 The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D (2015) Mol Cell 59: 998-1010 Checkpoint signaling from a single DNA interstrand crosslink. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Mol Cell 35: 704-15 Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback. de Bruin RA, Kalashnikova TI, Chahwan C, McDonald WH, Wohlschlegel J, Yates J, Russell P, Wittenberg C (2006) Mol Cell 23: 483-96 Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY (2012) Genes Dev 26: 1780-96 Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ (2000) Genes Dev 14: 1448-59 Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments. Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H (2012) J Cell Biol 199: 285-301 Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids. Pauta M, Rotllan N, Vales F, Fernandez-Hernando A, Allen RM, Ford DA, Marí M, Jiménez W, Baldán A, Morales-Ruiz M, Fernández-Hernando C (2013) J Hepatol 59: 731-7 Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer. Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ES, Liu L, Luo Z, Sun HL, Cui R, Wei H, Kim T, Lee TJ, Jeon YJ, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM (2013) Proc Natl Acad Sci U S A 110: 15043-8 CK1 is required for a mitotic checkpoint that delays cytokinesis. Johnson AE, Chen JS, Gould KL (2013) Curr Biol 23: 1920-6 Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress. Liu Y, Bertram CC, Shi Q, Zinkel SS (2011) Cell Death Differ 18: 841-52 The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice. Biswas S, Shi Q, Wernick A, Aiello A, Zinkel SS (2013) Cell Death Differ 20: 869-77 SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP (2013) Clin Cancer Res 19: 560-70 Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. Liu Y, Hawkins OE, Su Y, Vilgelm AE, Sobolik T, Thu YM, Kantrow S, Splittgerber RC, Short S, Amiri KI, Ecsedy JA, Sosman JA, Kelley MC, Richmond A (2013) EMBO Mol Med 5: 149-66 Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses. Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ (2015) J Pathol 236: 421-32 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Spurlock CF, Tossberg JT, Fuchs HA, Olsen NJ, Aune TM (2012) Arthritis Rheum 64: 1780-9 Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Maas K, Westfall M, Pietenpol J, Olsen NJ, Aune T (2005) Arthritis Rheum 52: 1047-57 Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN (2014) Oncotarget 5: 5637-50 no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila. Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA (2009) Development 136: 449-59 The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA (2007) J Cell Sci 120: 3565-77 In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells. Ratliff M, Alter S, McAvoy K, Frasca D, Wright JA, Zinkel SS, Khan WN, Blomberg BB, Riley RL (2015) Aging Cell 14: 382-90 Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis. Overstreet JM, Wang Y, Wang X, Niu A, Gewin LS, Yao B, Harris RC, Zhang MZ (2017) FASEB J 31: 4407-4421 Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase. King JB, Gross J, Lovly CM, Rohrs H, Piwnica-Worms H, Townsend RR (2006) Anal Chem 78: 2171-81 Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Chen Z, Xiao Z, Chen J, Ng SC, Sowin T, Sham H, Rosenberg S, Fesik S, Zhang H (2003) Mol Cancer Ther 2: 543-8 The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W (2012) Mol Cancer Ther 11: 763-74 Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Boddy MN, Shanahan P, McDonald WH, Lopez-Girona A, Noguchi E, Yates III JR, Russell P (2003) Mol Cell Biol 23: 5939-46 Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks. Herzberg K, Bashkirov VI, Rolfsmeier M, Haghnazari E, McDonald WH, Anderson S, Bashkirova EV, Yates JR, Heyer WD (2006) Mol Cell Biol 26: 8396-409 Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H (2008) Mol Cell Biol 28: 5874-85 The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Eischen CM, Lozano G (2014) Hum Mutat 35: 728-37 The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W (2013) Cancer 119: 904-14 Nonstructural protein σ1s mediates reovirus-induced cell cycle arrest and apoptosis. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS (2013) J Virol 87: 12967-79 Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. Guler GD, Liu H, Vaithiyalingam S, Arnett DR, Kremmer E, Chazin WJ, Fanning E (2012) J Biol Chem 287: 6469-81 Rapid activation of ATR by ionizing radiation requires ATM and Mre11. Myers JS, Cortez D (2006) J Biol Chem 281: 9346-50 Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H (2003) J Biol Chem 278: 21767-73 Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function. Johnson AE, Collier SE, Ohi MD, Gould KL (2012) J Biol Chem 287: 25741-8 Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. Cortez D (2003) J Biol Chem 278: 37139-45 Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast. Wang Y, Li WZ, Johnson AE, Luo ZQ, Sun XL, Feoktistova A, McDonald WH, McLeod I, Yates JR, Gould KL, McCollum D, Jin QW (2012) Mol Biol Cell 23: 3348-56 The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Den Haese GJ, Walworth N, Carr AM, Gould KL (1995) Mol Biol Cell 6: 371-85 ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Ball HL, Myers JS, Cortez D (2005) Mol Biol Cell 16: 2372-81
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