Keyword Connections

•  Amy Major
•  Daniel Moore
•  Eric Sebzda

•  Jonathan Irish
•  Peggy Kendall
•  Rachel Bonami

•  Subramaniam Sriram
•  Thomas Aune

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Communities

• James (Tom) Thomas Laboratory

Publications

• Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
  Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes TrialNet Abatacept Study Group
  (2011) Lancet 378: 412-9
• Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
  Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR
  (2017) Nature 545: 243-247
• T cells from patients with Parkinson's disease recognize α-synuclein peptides.
  Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A
  (2017) Nature 546: 656-661
• Reciprocal regulation between natural killer cells and autoreactive T cells.
  Shi FD, Van Kaer L
  (2006) Nat Rev Immunol 6: 751-60
• Organ-specific features of natural killer cells.
  Shi FD, Ljunggren HG, La Cava A, Van Kaer L
  (2011) Nat Rev Immunol 11: 658-71
• alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles.
  Van Kaer L
  (2005) Nat Rev Immunol 5: 31-42
• Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
  Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M
  (2012) Cell 148: 447-57
• Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
  (2006) Science 311: 1774-5
• Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases.
  Grijalva CG, Chen L, Delzell E, Baddley JW, Beukelman T, Winthrop KL, Griffin MR, Herrinton LJ, Liu L, Ouellet-Hellstrom R, Patkar NM, Solomon DH, Lewis JD, Xie F, Saag KG, Curtis JR
  (2011) JAMA 306: 2331-9
• Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster.
  Winthrop KL, Baddley JW, Chen L, Liu L, Grijalva CG, Delzell E, Beukelman T, Patkar NM, Xie F, Saag KG, Herrinton LJ, Solomon DH, Lewis JD, Curtis JR
  (2013) JAMA 309: 887-95
• Natural killer cells determine the outcome of B cell-mediated autoimmunity.
  Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG
  (2000) Nat Immunol 1: 245-51
• Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.
  Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA
  (2008) Nat Immunol 9: 658-66
• Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
  Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN
  (2007) Nat Med 13: 492-7
• Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
  Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC
  (2016) Nat Med 22: 1482-1487
• Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
  Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD
  (2016) Nat Neurosci 19: 243-52
• Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.
  Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL
  (2008) Endocr Rev 29: 603-30
• Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.
  Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y
  (2006) J Exp Med 203: 2603-11
• Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology.
  Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD
  (2010) J Exp Med 207: 1907-21
• Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.
  Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G
  (2009) J Exp Med 206: 2407-16
• Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.
  Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, Joyce S, Sriram S, Koezuka Y, Van Kaer L
  (2001) J Exp Med 194: 1801-11
• Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis.
  Olivares-Villagómez D, Wang Y, Lafaille JJ
  (1998) J Exp Med 188: 1883-94
• Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus.
  Harris RC, Brenner BM, Seifter JL
  (1986) J Clin Invest 77: 724-33
• FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
  Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW
  (2015) J Clin Invest 125: 1111-23
• Comeback kids: CD8(+) suppressor T cells are back in the game.
  Van Kaer L
  (2010) J Clin Invest 120: 3432-4
• Novel antibody markers of unstable atherosclerotic lesions.
  Bloch DB, Wang TJ, Gerszten RE
  (2008) J Clin Invest 118: 2675-7
• Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile.
  Joyce S, Van Kaer L
  (2008) Cell Host Microbe 3: 275-7
• Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice.
  Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L
  (1999) Immunol Rev 169: 31-44
• Regulatory T cells in spontaneous autoimmune encephalomyelitis.
  Furtado GC, Olivares-Villagómez D, Curotto de Lafaille MA, Wensky AK, Latkowski JA, Lafaille JJ
  (2001) Immunol Rev 182: 122-34
• Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation.
  Hao J, Campagnolo D, Liu R, Piao W, Shi S, Hu B, Xiang R, Zhou Q, Vollmer T, Van Kaer L, La Cava A, Shi FD
  (2011) Ann Neurol 69: 721-34
• Type 2 diabetes mellitus--an autoimmune disease?
  Velloso LA, Eizirik DL, Cnop M
  (2013) Nat Rev Endocrinol 9: 750-5
• Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells.
  Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA
  (2009) Gut 58: 1267-74
• Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
  Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP
  (2018) Nat Commun 9: 260
• Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.
  Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, Heinegård D, Hudson BG
  (1984) Proc Natl Acad Sci U S A 81: 3838-42
• Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.
  Martin DA, Zheng L, Siegel RM, Huang B, Fisher GH, Wang J, Jackson CE, Puck JM, Dale J, Straus SE, Peter ME, Krammer PH, Fesik S, Lenardo MJ
  (1999) Proc Natl Acad Sci U S A 96: 4552-7
• CD318 is a ligand for CD6.
  Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F
  (2017) Proc Natl Acad Sci U S A 114: E6912-E6921