Keyword Connections

•  Alissa Weaver
•  Anna Vilgelm
•  Austin Kirschner
•  BethAnn McLaughlin
•  Carlos Arteaga

•  Charles Hong
•  Eugenia Gurevich
•  James Goldenring
•  James Lewis Jr.
•  Peggy Kendall

•  Robert Macdonald
•  Roger Colbran
•  Serk In Park
•  Yan Liu

Resources

• No matching connections

Communities

• Goldenring Lab
• Hong Lab
• Richmond Lab

Publications

• Cancer-drug discovery and cardiovascular surveillance.
  Groarke JD, Cheng S, Moslehi J
  (2013) N Engl J Med 369: 1779-81
• Erlotinib in lung cancer.
  Pao W, Ladanyi M, Miller VA, Lung Cancer Oncogenome Group
  (2005) N Engl J Med 353: 1739-41; author reply 1739-41
• Cardiovascular Toxic Effects of Targeted Cancer Therapies.
  Moslehi JJ
  (2016) N Engl J Med 375: 1457-1467
• Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred.
  Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE
  (2001) N Engl J Med 345: 319-24
• Reversible cardiomyopathy associated with sunitinib and sorafenib.
  Uraizee I, Cheng S, Moslehi J
  (2011) N Engl J Med 365: 1649-50
• Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.
  Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, Kovacevic Z, Lesovoy V, Schmidt-Wolf IG, Barbarash O, Gokmen E, O'Toole T, Lustgarten S, Moore L, Motzer RJ, Global ARCC Trial
  (2007) N Engl J Med 356: 2271-81
• RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
  Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, Reis-Filho JS, Kong X, Koya RC, Flaherty KT, Chapman PB, Kim MJ, Hayward R, Martin M, Yang H, Wang Q, Hilton H, Hang JS, Noe J, Lambros M, Geyer F, Dhomen N, Niculescu-Duvaz I, Zambon A, Niculescu-Duvaz D, Preece N, Robert L, Otte NJ, Mok S, Kee D, Ma Y, Zhang C, Habets G, Burton EA, Wong B, Nguyen H, Kockx M, Andries L, Lestini B, Nolop KB, Lee RJ, Joe AK, Troy JL, Gonzalez R, Hutson TE, Puzanov I, Chmielowski B, Springer CJ, McArthur GA, Sosman JA, Lo RS, Ribas A, Marais R
  (2012) N Engl J Med 366: 207-15
• Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
  Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J
  (2012) N Engl J Med 367: 1694-703
• Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators.
  Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O'Hanesian MA, Wagner GS, Kleiman NS, Harrell FE, Califf RM, Topol EJ
  (1996) N Engl J Med 335: 1333-41
• Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
  Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R
  (2012) Nature 483: 100-3
• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
  Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K
  (2010) Nature 467: 596-9
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
  Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB
  (2011) Nature 480: 387-90
• Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
  Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
  (1995) Nature 378: 584-92
• Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
  Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
  (2012) Nature 487: 505-9
• Comprehensive molecular portraits of human breast tumours.
  Cancer Genome Atlas Network
  (2012) Nature 490: 61-70
• Integrin-linked kinase is an adaptor with essential functions during mouse development.
  Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R
  (2009) Nature 461: 1002-6
• TBP-associated factors are not generally required for transcriptional activation in yeast.
  Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl K
  (1996) Nature 383: 188-91
• Syk tyrosine kinase required for mouse viability and B-cell development.
  Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
  (1995) Nature 378: 303-6
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.
  Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV
  (1996) Nature 383: 716-9
• Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
  Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW
  (2005) Nature 436: 807-11
• Immunology: TRIM5 does double duty.
  Aiken C, Joyce S
  (2011) Nature 472: 305-6
• Leptin regulation of bone resorption by the sympathetic nervous system and CART.
  Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
  (2005) Nature 434: 514-20
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• p19ARF directly and differentially controls the functions of c-Myc independently of p53.
  Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR
  (2004) Nature 431: 712-7