PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M (2001) Proc Natl Acad Sci U S A 98: 1065-70 A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1. Kagawa N, Ogo A, Takahashi Y, Iwamatsu A, Waterman MR (1994) J Biol Chem 269: 18716-9 Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. Bischof LJ, Kagawa N, Moskow JJ, Takahashi Y, Iwamatsu A, Buchberg AM, Waterman MR (1998) J Biol Chem 273: 7941-8 The homeodomain protein Pbx1 is involved in cAMP-dependent transcription of human CYP17. Ogo A, Waterman MR, McAllister JM, Kagawa N (1997) Arch Biochem Biophys 348: 226-31 The bovine CYP17 promoter contains a transcriptional regulatory element cooperatively bound by tale homeodomain proteins. Bischof LJ, Kagawa N, Waterman MR (1998) Endocr Res 24: 489-95
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