Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. Swart P, Swart AC, Waterman MR, Estabrook RW, Mason JI (1993) J Clin Endocrinol Metab 77: 98-102 Conformational selection dominates binding of steroids to human cytochrome P450 17A1. Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ (2019) J Biol Chem 294: 10028-10041 Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR (2012) J Biol Chem 287: 10613-22 Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism. Mathew RP, Najjar JL, Lorenz RA, Mayes DE, Russell WE (2002) J Pediatr 141: 91-8 Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species. Brock BJ, Waterman MR (1999) Biochemistry 38: 1598-606 The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Katagiri M, Kagawa N, Waterman MR (1995) Arch Biochem Biophys 317: 343-7 Expression of a full-length cDNA encoding bovine adrenal cytochrome P450C21. Lorence MC, Trant JM, Mason JI, Bhasker CR, Fujii-Kuriyama Y, Estabrook RW, Waterman MR (1989) Arch Biochem Biophys 273: 79-88 Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy. Blind RD, Pineda-Torra I, Xu Y, Xu HE, Garabedian MJ (2012) Biochem Biophys Res Commun 420: 839-44 Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli. Arase M, Waterman MR, Kagawa N (2006) Biochem Biophys Res Commun 344: 400-5
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.