Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. Anandatheerthavarada HK, Amuthan G, Biswas G, Robin MA, Murali R, Waterman MR, Avadhani NG (2001) EMBO J 20: 2394-403 Flavodoxin as a model for the P450-interacting domain of NADPH cytochrome P450 reductase. Jenkins CM, Waterman MR (1999) Drug Metab Rev 31: 195-203 Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities. Jenkins CM, Waterman MR (1994) J Biol Chem 269: 27401-8 Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE (2008) J Biol Chem 283: 8183-9 Negatively charged anabaena flavodoxin residues (Asp144 and Glu145) are important for reconstitution of cytochrome P450 17alpha-hydroxylase activity. Jenkins CM, Genzor CG, Fillat MF, Waterman MR, Gómez-Moreno C (1997) J Biol Chem 272: 22509-13 NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase. Jenkins CM, Waterman MR (1998) Biochemistry 37: 6106-13 Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. Dong MS, Yamazaki H, Guo Z, Guengerich FP (1996) Arch Biochem Biophys 327: 11-9 Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction. Jenkins CM, Pikuleva I, Kagawa N, Waterman MR (1997) Arch Biochem Biophys 347: 93-102
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.