AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P (2005) Cell 120: 663-74 APOBEC3G complexes decrease human immunodeficiency virus type 1 production. Martin KL, Johnson M, D'Aquila RT (2011) J Virol 85: 9314-26 Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. Aiken C (1997) J Virol 71: 5871-7 Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles. Wyma DJ, Kotov A, Aiken C (2000) J Virol 74: 9381-7 Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. Schneidewind A, Brockman MA, Yang R, Adam RI, Li B, Le Gall S, Rinaldo CR, Craggs SL, Allgaier RL, Power KA, Kuntzen T, Tung CS, LaBute MX, Mueller SM, Harrer T, McMichael AJ, Goulder PJ, Aiken C, Brander C, Kelleher AD, Allen TM (2007) J Virol 81: 12382-93 Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail. Jiang J, Aiken C (2007) J Virol 81: 9999-10008 Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag. Zhou J, Chen CH, Aiken C (2006) J Virol 80: 12095-101 A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41. Davis MR, Jiang J, Zhou J, Freed EO, Aiken C (2006) J Virol 80: 2405-17 Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. Zhou J, Yuan X, Dismuke D, Forshey BM, Lundquist C, Lee KH, Aiken C, Chen CH (2004) J Virol 78: 922-9 Structural requirements for recognition of the human immunodeficiency virus type 1 core during host restriction in owl monkey cells. Forshey BM, Shi J, Aiken C (2005) J Virol 79: 869-75 Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV. Hicar MD, Chen X, Briney B, Hammonds J, Wang JJ, Kalams S, Spearman PW, Crowe JE (2010) J Acquir Immune Defic Syndr 54: 223-35 Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. Zhou J, Huang L, Hachey DL, Chen CH, Aiken C (2005) J Biol Chem 280: 42149-55 Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, Yeh JI (2011) J Mol Biol 406: 371-86 Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein. Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF (2016) J Mol Biol 428: 1637-55 HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S (2009) PLoS One 4: e6687 Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein. Chukwuma VU, Hicar MD, Chen X, Nicholas KJ, Joyner A, Kalams SA, Landucci G, Forthal DN, Spearman PW, Crowe JE (2015) PLoS One 10: e0133509 Nef enhances HIV-1 infectivity via association with the virus assembly complex. Qi M, Aiken C (2008) Virology 373: 287-97 Rheumatoid arthritis is associated with IgG antibodies to human endogenous retrovirus gag matrix: a potential pathogenic mechanism of disease? Nelson PN, Roden D, Nevill A, Freimanis GL, Trela M, Ejtehadi HD, Bowman S, Axford J, Veitch AM, Tugnet N, Rylance PB (2014) J Rheumatol 41: 1952-60
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