Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P (2011) Gastroenterology 141: 2140-53 Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD (2005) J Clin Invest 115: 1765-76 Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM (2015) Gut 64: 720-30 Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P (2014) Gut 63: 622-34 Sex-specific genetic predictors of Alzheimer's disease biomarkers. Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ (2018) Acta Neuropathol 136: 857-872 Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Shiou SR, Singh AB, Moorthy K, Datta PK, Washington MK, Beauchamp RD, Dhawan P (2007) Cancer Res 67: 1571-9 Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB (2011) Oncogene 30: 3234-47 Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner. Gowrikumar S, Ahmad R, Uppada SB, Washington MK, Shi C, Singh AB, Dhawan P (2019) Oncogene 38: 5321-5337 HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Krishnan M, Singh AB, Smith JJ, Sharma A, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD, Dhawan P (2010) Oncogene 29: 305-12 Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling. Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P, Singh AB (2017) Oncogene 36: 6592-6604 Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Bhat AA, Pope JL, Smith JJ, Ahmad R, Chen X, Washington MK, Beauchamp RD, Singh AB, Dhawan P (2015) Oncogene 34: 4570-80 Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB (2014) Mucosal Immunol 7: 1340-53 Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. Sharma A, Bhat AA, Krishnan M, Singh AB, Dhawan P (2013) Carcinogenesis 34: 2610-21 Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner. Singh AB, Sharma A, Dhawan P (2012) Carcinogenesis 33: 2538-47 STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT (2013) J Immunol 190: 1849-58 Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis. Pope JL, Ahmad R, Bhat AA, Washington MK, Singh AB, Dhawan P (2014) Mol Cancer 13: 167 STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB (2011) Inflamm Bowel Dis 17: 2224-34 Smad7 induces hepatic metastasis in colorectal cancer. Halder SK, Rachakonda G, Deane NG, Datta PK (2008) Br J Cancer 99: 957-65 Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. Singh AB, Harris RC (2004) J Biol Chem 279: 3543-52 The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R (2014) J Biol Chem 289: 8532-44 Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR (2012) Mol Biol Cell 23: 2302-18 Rab25 regulates integrin expression in polarized colonic epithelial cells. Krishnan M, Lapierre LA, Knowles BC, Goldenring JR (2013) Mol Biol Cell 24: 818-31 Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA, El-Rifai W (2005) Am J Pathol 167: 577-84 Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Lioni M, Brafford P, Andl C, Rustgi A, El-Deiry W, Herlyn M, Smalley KS (2007) Am J Pathol 170: 709-21 Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP (2016) J Neuroinflammation 13: 306 Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. Bhat AA, Sharma A, Pope J, Krishnan M, Washington MK, Singh AB, Dhawan P (2012) PLoS One 7: e37174 Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ. Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS (2014) Invest Ophthalmol Vis Sci 55: 8232-40 The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing. Mittendorf KF, Kroncke BM, Meiler J, Sanders CR (2014) Biochemistry 53: 6139-41 Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Smith JJ, Deane NG, Dhawan P, Beauchamp RD (2008) Surgery 144: 353-66 The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells. Foster CD, Varghese LS, Gonzales LW, Margulies SS, Guttentag SH (2010) Pediatr Res 67: 585-90 Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK, Sosa-Pineda B (2012) Dev Dyn 241: 583-94 Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. Mittal MK, Myers JN, Bailey CK, Misra S, Chaudhuri G (2010) Mol Biol Rep 37: 1221-7 Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens. Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J (2015) Biochem Biophys Res Commun 459: 87-93
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.