Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB (2014) Cancer Res 74: 2062-72 Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P (2003) Mol Cell Biol 23: 3052-66 Systemic bile acids induce insulin resistance in a TGR5-independent manner. Syring KE, Cyphert TJ, Beck TC, Flynn CR, Mignemi NA, McGuinness OP (2019) Am J Physiol Endocrinol Metab 316: E782-E793 Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization. Lertpiriyapong K, Gamazon ER, Feng Y, Park DS, Pang J, Botka G, Graffam ME, Ge Z, Fox JG (2012) PLoS One 7: e42842 PLC-gamma1 regulates fibronectin assembly and cell aggregation. Crooke CE, Pozzi A, Carpenter GF (2009) Exp Cell Res 315: 2207-14 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Merchant NB, Rogers CM, Trivedi B, Morrow J, Coffey RJ (2005) Surgery 138: 415-21
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.