p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. Aono S, Nakagawa S, Reynolds AB, Takeichi M (1999) J Cell Biol 145: 551-62 Urinary isothiocyanate levels, brassica, and human breast cancer. Fowke JH, Chung FL, Jin F, Qi D, Cai Q, Conaway C, Cheng JR, Shu XO, Gao YT, Zheng W (2003) Cancer Res 63: 3980-6 The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Deweese JE, Osheroff N (2009) Nucleic Acids Res 37: 738-48 Model of inhibition of the NPM-ALK kinase activity by herbimycin A. Turturro F, Arnold MD, Frist AY, Pulford K (2002) Clin Cancer Res 8: 240-5 Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease. SantaCruz KS, Yazlovitskaya E, Collins J, Johnson J, DeCarli C (2004) Neurobiol Aging 25: 63-9 Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Burk RF, Hill KE, Nakayama A, Mostert V, Levander XA, Motley AK, Johnson DA, Johnson JA, Freeman ML, Austin LM (2008) Free Radic Biol Med 44: 1617-23 Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, Sawyer DB (2005) J Biol Chem 280: 13148-52 NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation. Kummarapurugu AB, Fischer BM, Zheng S, Milne GL, Ghio AJ, Potts-Kant EN, Foster WM, Soderblom EJ, Dubois LG, Moseley MA, Thompson JW, Voynow JA (2013) J Biol Chem 288: 4681-91 Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase. Dikalov S, Landmesser U, Harrison DG (2002) J Biol Chem 277: 25480-5 Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms. Fowke JH, Shu XO, Dai Q, Jin F, Cai Q, Gao YT, Zheng W (2004) Cancer Epidemiol Biomarkers Prev 13: 1308-15 Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O (2016) Mitochondrion 28: 88-95 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ (1999) J Neurochem 72: 1617-24 Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Bender RP, Osheroff N (2007) Chem Res Toxicol 20: 975-81 PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS (2011) Am J Physiol Lung Cell Mol Physiol 301: L615-22 Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Lovett BD, Strumberg D, Blair IA, Pang S, Burden DA, Megonigal MD, Rappaport EF, Rebbeck TR, Osheroff N, Pommier YG, Felix CA (2001) Biochemistry 40: 1159-70 Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Bender RP, Ham AJ, Osheroff N (2007) Biochemistry 46: 2856-64 Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N (2006) Biochemistry 45: 10140-52 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T (1999) Drug Metab Dispos 27: 1260-6 Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. McCollum GW, Rajaratnam VS, Bullard LE, Yang R, Penn JS (2004) Exp Eye Res 78: 987-95 Role of iron ion chelation by quinones in their reduction, OH-radical generation and lipid peroxidation. Dikalov S, Alov P, Rangelova D (1993) Biochem Biophys Res Commun 195: 113-9
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