Sonic hedgehog is essential to foregut development. Litingtung Y, Lei L, Westphal H, Chiang C (1998) Nat Genet 20: 58-61 Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Kelly OG, Chan MY, Martinson LA, Kadoya K, Ostertag TM, Ross KG, Richardson M, Carpenter MK, D'Amour KA, Kroon E, Moorman M, Baetge EE, Bang AG (2011) Nat Biotechnol 29: 750-6 Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L (2012) J Clin Invest 122: 3516-28 Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T (2006) J Clin Invest 116: 1484-93 Kindlin-2 controls bidirectional signaling of integrins. Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R (2008) Genes Dev 22: 1325-30 The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A (2013) EMBO J 32: 1393-408 Dual lineage-specific expression of Sox17 during mouse embryogenesis. Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ, Grapin-Botton A, Magnuson MA (2012) Stem Cells 30: 2297-308 BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Yang YP, Anderson RM, Klingensmith J (2010) Hum Mol Genet 19: 3030-42 Fgf8 is required for anterior heart field development. Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN (2006) Development 133: 2435-45 Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Osada SI, Wright CV (1999) Development 126: 3229-40 Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Erter CE, Wilm TP, Basler N, Wright CV, Solnica-Krezel L (2001) Development 128: 3571-83 Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD (2004) Development 131: 4213-24 Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R (2007) Development 134: 535-44 Dominant and context-specific control of endodermal organ allocation by Ptf1a. Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV (2014) Development 141: 4385-94 Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development. Li N, Wei C, Olena AF, Patton JG (2011) Development 138: 1817-26 Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Gannon M, Bader D (1995) Development 121: 2439-50 PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV (1996) Development 122: 983-95 XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Wright CV, Schnegelsberg P, De Robertis EM (1989) Development 105: 787-94 MafA is a dedicated activator of the insulin gene in vivo. Artner I, Hang Y, Guo M, Gu G, Stein R (2008) J Endocrinol 198: 271-9 Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Gannon M, Gamer LW, Wright CV (2001) Dev Biol 238: 185-201 A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo. Becker S, Wang ZJ, Massey H, Arauz A, Labosky P, Hammerschmidt M, St-Jacques B, Bumcrot D, McMahon A, Grabel L (1997) Dev Biol 187: 298-310 Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. Gamer LW, Wright CV (1995) Dev Biol 171: 240-51 Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA (2007) Dev Biol 304: 541-55 Diversification of cardiomyogenic cell lineages in vitro. Yutzey K, Gannon M, Bader D (1995) Dev Biol 170: 531-41 Homeobox-containing genes in teratocarcinoma embryoid bodies: a possible role for Hox-D12 (Hox-4.7) in establishing the extraembryonic endoderm lineage in the mouse. Labosky PA, Weir MP, Grabel LB (1993) Dev Biol 159: 232-44 Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. Cha YR, Takahashi S, Wright CV (2006) Dev Biol 290: 246-64 Endodermal expression of Nkx6 genes depends differentially on Pdx1. Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P, Beta Cell Biology Consortium (2005) Dev Biol 288: 487-501 Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction. Tanaka ST, Ishii K, Demarco RT, Pope JC, Brock JW, Hayward SW (2010) J Urol 183: 386-91 Transcriptional dynamics of endodermal organ formation. Sherwood RI, Chen TY, Melton DA (2009) Dev Dyn 238: 29-42 Relationship between fibronectin expression during gastrulation and heart formation in the rat embryo. Suzuki HR, Solursh M, Baldwin HS (1995) Dev Dyn 204: 259-77 A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA (2012) Genesis 50: 384-92
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