Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV (2019) Proc Natl Acad Sci U S A 116: 810-815 IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation. Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J (2017) Oncotarget 8: 43153-43168 The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, Przybysz AJ, Strange K (2009) Mol Cell Biol 29: 2704-15 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). Shajahan AN, Dobbin ZC, Hickman FE, Dakshanamurthy S, Clarke R (2012) J Biol Chem 287: 17682-92 Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. Breitman M, Kook S, Gimenez LE, Lizama BN, Palazzo MC, Gurevich EV, Gurevich VV (2012) J Biol Chem 287: 19653-64 JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases. Zhan X, Kaoud TS, Kook S, Dalby KN, Gurevich VV (2013) J Biol Chem 288: 28535-47 Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. Komalavilas P, Shah PK, Jo H, Lincoln TM (1999) J Biol Chem 274: 34301-9 Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. Engel ME, McDonnell MA, Law BK, Moses HL (1999) J Biol Chem 274: 37413-20 A secreted MMP is required for reepithelialization during wound healing. Stevens LJ, Page-McCaw A (2012) Mol Biol Cell 23: 1068-79 Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Feoktistov I, Goldstein AE, Biaggioni I (1999) Mol Pharmacol 55: 726-34 Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant. Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV (2013) Cell Signal 25: 2613-24 Methotrexate-mediated inhibition of nuclear factor κB activation by distinct pathways in T cells and fibroblast-like synoviocytes. Spurlock CF, Gass HM, Bryant CJ, Wells BC, Olsen NJ, Aune TM (2015) Rheumatology (Oxford) 54: 178-87 The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Hsiang CH, Tunoda T, Whang YE, Tyson DR, Ornstein DK (2006) Prostate 66: 1413-24 Antagonistic effects of TGFbeta1 and BMP-6 on skin keratinocyte differentiation. McDonnell MA, Law BK, Serra R, Moses HL (2001) Exp Cell Res 263: 265-73 Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex. Zhan X, Kaoud TS, Dalby KN, Gurevich VV (2011) Biochemistry 50: 10520-9 Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium. Communal C, Colucci WS, Remondino A, Sawyer DB, Port JD, Wichman SE, Bristow MR, Singh K (2002) J Card Fail 8: 86-92
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