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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Sodium Channels are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for Sodium Channels.
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- Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R
(2013) Nat Genet 45: 1044-9 - Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply.
Van Driest SL, Wells QS, Roden DM
(2016) JAMA 315: 2467-8 - Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM
(2016) JAMA 315: 47-57 - Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption.
Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD
(2005) Nat Med 11: 861-6 - Relating form and function of EF-hand calcium binding proteins.
Chazin WJ
(2011) Acc Chem Res 44: 171-9 - Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
Chatzigeorgiou M, Yoo S, Watson JD, Lee WH, Spencer WC, Kindt KS, Hwang SW, Miller DM, Treinin M, Driscoll M, Schafer WR
(2010) Nat Neurosci 13: 861-8 - Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM
(2010) Circulation 122: 2016-21 - Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM
(2011) Circulation 124: 1001-11 - Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.
Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL, Roden DM
(2002) Circulation 105: 1943-8 - Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.
Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM
(2014) Circulation 130: 224-34 - Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.
Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D
(2012) J Am Coll Cardiol 60: 1173-81 - Effect of chemically induced diabetes mellitus on glutamine transport in rat intestine.
Van Voorhis K, Said HM, Abumrad N, Ghishan FK
(1990) Gastroenterology 98: 862-6 - Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125: 2136-50 - Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance.
Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC
(2003) J Clin Invest 112: 554-65 - Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH
(2006) J Clin Invest 116: 1696-702 - Transcription factor ETV1 is essential for rapid conduction in the heart.
Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS
(2016) J Clin Invest 126: 4444-4459 - Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current.
Zhou J, Shin HG, Yi J, Shen W, Williams CP, Murray KT
(2002) Circ Res 91: 540-6 - Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM
(2012) Circ Res 111: 322-32 - Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.
Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR
(2005) Circ Res 97: 1262-9 - Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.
Zhou J, Yi J, Hu N, George AL, Murray KT
(2000) Circ Res 87: 33-8 - Voltage-gated sodium channels are required for heart development in zebrafish.
Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM
(2010) Circ Res 106: 1342-50 - Functional effects of protein kinase C activation on the human cardiac Na+ channel.
Murray KT, Hu NN, Daw JR, Shin HG, Watson MT, Mashburn AB, George AL
(1997) Circ Res 80: 370-6 - Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.
Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM
(2011) Circ Res 109: 38-46 - Loss of protein kinase C inhibition in the beta-T594M variant of the amiloride-sensitive Na+ channel.
Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RY
(1997) Proc Natl Acad Sci U S A 94: 9962-6
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