Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. Levin GP, Robinson-Cohen C, de Boer IH, Houston DK, Lohman K, Liu Y, Kritchevsky SB, Cauley JA, Tanaka T, Ferrucci L, Bandinelli S, Patel KV, Hagström E, Michaëlsson K, Melhus H, Wang T, Wolf M, Psaty BM, Siscovick D, Kestenbaum B (2012) JAMA 308: 1898-905 Sunlight and reduced risk of cancer: is the real story vitamin D? Egan KM, Sosman JA, Blot WJ (2005) J Natl Cancer Inst 97: 161-3 ACP Journal Club. Review: cholecalciferol (vitamin D3) reduces mortality in adults; other forms of vitamin D do not. Murff HJ (2011) Ann Intern Med 155: JC5-04 Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. Egan JB, Thompson PA, Ashbeck EL, Conti DV, Duggan D, Hibler E, Jurutka PW, Leroy EC, Martínez ME, Mount D, Jacobs ET (2010) Cancer Res 70: 1496-504 Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD (2010) Arterioscler Thromb Vasc Biol 30: 2648-54 Vitamin D receptor gene polymorphisms are linked to and associated with adult height. Xiong DH, Xu FH, Liu PY, Shen H, Long JR, Elze L, Recker RR, Deng HW (2005) J Med Genet 42: 228-34 A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. Liu PY, Zhang YY, Lu Y, Long JR, Shen H, Zhao LJ, Xu FH, Xiao P, Xiong DH, Liu YJ, Recker RR, Deng HW (2005) J Med Genet 42: 221-7 Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro. Li X, Okada Y, Pilbeam CC, Lorenzo JA, Kennedy CR, Breyer RM, Raisz LG (2000) Endocrinology 141: 2054-61 Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. Halder SK, Osteen KG, Al-Hendy A (2013) Hum Reprod 28: 2407-16 Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women. Dorjgochoo T, Delahanty R, Lu W, Long J, Cai Q, Zheng Y, Gu K, Gao YT, Zheng W, Shu XO (2011) Cancer Epidemiol Biomarkers Prev 20: 2313-6 Lactose, calcium source and age affect calcium bioavailability in rats. Buchowski MS, Miller DD (1991) J Nutr 121: 1746-54 1,25-dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells. Halder SK, Osteen KG, Al-Hendy A (2013) Biol Reprod 89: 150 Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. Hibler EA, Jurutka PW, Egan JB, Hu C, LeRoy EC, Martinez ME, Thompson PA, Jacobs ET (2010) J Steroid Biochem Mol Biol 121: 438-41 Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, Long J, Cohen SS, Li G, Hollis BW, Smith JR, Blot WJ (2011) PLoS One 6: e28623 Oral vitamin D supplementation reduces the incidence of eucalcemic PTH elevation after surgery for primary hyperparathyroidism. Beyer TD, Solorzano CC, Prinz RA, Babu A, Nilubol N, Patel S (2007) Surgery 141: 777-83 Associations between circulating 1,25(OH)₂D concentration and odds of metachronous colorectal adenoma. Hibler EA, Molmenti CL, Lance P, Jurutka PW, Jacobs ET (2014) Cancer Causes Control 25: 809-17 Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Bea JW, Jurutka PW, Hibler EA, Lance P, Martínez ME, Roe DJ, Sardo Molmenti CL, Thompson PA, Jacobs ET (2015) Metabolism 64: 447-59 Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. Long JR, Zhao LJ, Liu PY, Lu Y, Dvornyk V, Shen H, Liu YJ, Zhang YY, Xiong DH, Xiao P, Deng HW (2004) BMC Genet 5: 11 Association of estrogen receptor alpha and vitamin D receptor gene polymorphisms with bone mineral density in Chinese males. Long JR, Zhang YY, Liu PY, Liu YJ, Shen H, Dvornyk V, Zhao LJ, Deng HW (2004) Calcif Tissue Int 74: 270-6 Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: review of epidemiologic literature. Neuhouser ML, Kristal AR, Penson DF (2004) Urology 64: 201-11 Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women. Zhang YY, Long JR, Liu PY, Liu YJ, Shen H, Zhao LJ, Deng HW (2003) Biochem Biophys Res Commun 308: 777-83 In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells. Mittal MK, Myers JN, Misra S, Bailey CK, Chaudhuri G (2008) Biochem Biophys Res Commun 372: 30-4 Interaction effects between estrogen receptor alpha gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese. Long J, Liu P, Zhang Y, Shen H, Liu Y, Dvornyk V, Deng HW (2003) J Hum Genet 48: 514-519 Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese women. Xu H, Long JR, Li MX, Deng HW (2005) Acta Pharmacol Sin 26: 860-4 Vitamin D receptor gene as a candidate gene for Parkinson disease. Butler MW, Burt A, Edwards TL, Zuchner S, Scott WK, Martin ER, Vance JM, Wang L (2011) Ann Hum Genet 75: 201-10 Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. Dvornyk V, Long JR, Liu PY, Shen H, Recker RR, Deng HW (2006) Gynecol Endocrinol 22: 552-6 Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass. Dvornyk V, Liu PY, Long JR, Zhang YY, Lei SF, Recker RR, Deng HW (2005) Chin Med J (Engl) 118: 1235-44
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.