Regulation of a Golgi flippase by phosphoinositides and an ArfGEF. Natarajan P, Liu K, Patil DV, Sciorra VA, Jackson CL, Graham TR (2009) Nat Cell Biol 11: 1421-6 Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N (2007) Circ Res 100: 96-104 Flippases and vesicle-mediated protein transport. Graham TR (2004) Trends Cell Biol 14: 670-7 Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. Chen CY, Ingram MF, Rosal PH, Graham TR (1999) J Cell Biol 147: 1223-36 Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport. Xu P, Baldridge RD, Chi RJ, Burd CG, Graham TR (2013) J Cell Biol 202: 875-86 Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. Baldridge RD, Graham TR (2012) Proc Natl Acad Sci U S A 109: E290-8 Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases. Baldridge RD, Graham TR (2013) Proc Natl Acad Sci U S A 110: E358-67 Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Natarajan P, Wang J, Hua Z, Graham TR (2004) Proc Natl Acad Sci U S A 101: 10614-9 Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast. Zhou X, Graham TR (2009) Proc Natl Acad Sci U S A 106: 16586-91 Arl1 gets into the membrane remodeling business with a flippase and ArfGEF. Graham TR (2013) Proc Natl Acad Sci U S A 110: 2691-2 Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA (2005) Proc Natl Acad Sci U S A 102: 17071-6 Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Gall WE, Geething NC, Hua Z, Ingram MF, Liu K, Chen SI, Graham TR (2002) Curr Biol 12: 1623-7 Increased susceptibility of the sickle cell membrane Ca2+ + Mg(2+)-ATPase to t-butylhydroperoxide: protective effects of ascorbate and desferal. Moore RB, Hulgan TM, Green JW, Jenkins LD (1992) Blood 79: 1334-41 HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N (2013) Antioxid Redox Signal 19: 1185-97 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy. Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ (2017) Circ Heart Fail 10: Plasma membrane Ca(2+) -ATPase associates with CLP36, alpha-actinin and actin in human platelets. Bozulic LD, Malik MT, Powell DW, Nanez A, Link AJ, Ramos KS, Dean WL (2007) Thromb Haemost 97: 587-97 Altered force-frequency response in non-failing hearts with decreased SERCA pump-level. Huke S, Liu LH, Biniakiewicz D, Abraham WT, Periasamy M (2003) Cardiovasc Res 59: 668-77 Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia. Konradi C, Westin JE, Carta M, Eaton ME, Kuter K, Dekundy A, Lundblad M, Cenci MA (2004) Neurobiol Dis 17: 219-36 CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM (2007) J Mol Cell Cardiol 42: 196-205 SERCA pump level is a critical determinant of Ca(2+)homeostasis and cardiac contractility. Periasamy M, Huke S (2001) J Mol Cell Cardiol 33: 1053-63 Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane. Chen S, Wang J, Muthusamy BP, Liu K, Zare S, Andersen RJ, Graham TR (2006) Traffic 7: 1503-17 Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail. Zhou X, Sebastian TT, Graham TR (2013) J Biol Chem 288: 31807-15 Two Ca2+-dependent ATPases in rat liver plasma membrane. The previously purified (Ca2+-Mg2+)-ATPase is not a Ca2+-pump but an ecto-ATPase. Lin SH, Russell WE (1988) J Biol Chem 263: 12253-8 Type IV P-type ATPases distinguish mono- versus diacyl phosphatidylserine using a cytofacial exit gate in the membrane domain. Baldridge RD, Xu P, Graham TR (2013) J Biol Chem 288: 19516-27 P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes. Liu K, Surendhran K, Nothwehr SF, Graham TR (2008) Mol Biol Cell 19: 3526-35 Phosphatidylserine translocation at the yeast trans-Golgi network regulates protein sorting into exocytic vesicles. Hankins HM, Sere YY, Diab NS, Menon AK, Graham TR (2015) Mol Biol Cell 26: 4674-85 An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system. Hua Z, Fatheddin P, Graham TR (2002) Mol Biol Cell 13: 3162-77 Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue. Muthusamy BP, Raychaudhuri S, Natarajan P, Abe F, Liu K, Prinz WA, Graham TR (2009) Mol Biol Cell 20: 2920-31 Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD/Sla1p endocytic pathway. Liu K, Hua Z, Nepute JA, Graham TR (2007) Mol Biol Cell 18: 487-500 Inactivation of single Ca2+ channels in rat sensory neurons by extracellular Ca2+. Galli A, Ferroni A, Bertollini L, Mazzanti M (1994) J Physiol 477: 15-26 Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study. Zhao J, Zhu X, Shrubsole MJ, Ness RM, Hibler EA, Cai Q, Long J, Chen Z, Jiang M, Kabagambe EK, Zhang B, Hou L, Smalley WE, Edwards TL, Giovannucci EL, Zheng W, Dai Q (2017) Mol Carcinog 56: 2258-2266 Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. McDuffee AT, Senisterra G, Huntley S, Lepock JR, Sekhar KR, Meredith MJ, Borrelli MJ, Morrow JD, Freeman ML (1997) J Cell Physiol 171: 143-51 Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. Winder DG, Conn PJ (1995) J Neurochem 64: 592-9 Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger. Linck B, Bokník P, Huke S, Kirchhefer U, Knapp J, Lüss H, Müller FU, Neumann J, Tanriseven Z, Vahlensieck U, Baba HA, Jones LR, Philipson KD, Schmitz W (2000) J Pharmacol Exp Ther 294: 648-57 A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics. Hutter MC, Krebs J, Meiler J, Griesinger C, Carafoli E, Helms V (2002) Chembiochem 3: 1200-8 Mitochondrial calcium handling within the interstitial cells of Cajal. Means SA, Cheng LK (2014) Am J Physiol Gastrointest Liver Physiol 307: G107-21 Antioxidant network expression abrogates oxidative posttranslational modifications in mice. Mital R, Zhang W, Cai M, Huttinger ZM, Goodman LA, Wheeler DG, Ziolo MT, Dwyer KM, d'Apice AJ, Zweier JL, He G, Cowan PJ, Gumina RJ (2011) Am J Physiol Heart Circ Physiol 300: H1960-70
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.