Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Benning SD, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Cole D, Kessler RM, Zald DH (2010) Nat Neurosci 13: 419-21 Evidence against dopamine D1/D2 receptor heteromers. Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA (2015) Mol Psychiatry 20: 1373-85 A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype. Doyle SE, Ramôa C, Garber G, Newman J, Toor Z, Lynch WJ (2014) Biol Psychiatry 76: 810-5 Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia. Konradi C, Heckers S (2001) Biol Psychiatry 50: 729-42 PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R (2015) Neuropsychopharmacology 40: 927-37 Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses. Joffe ME, Turner BD, Delpire E, Grueter BA (2018) Neuropsychopharmacology 43: 2383-2389 Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Schramm-Sapyta NL, Olsen CM, Winder DG (2006) Neuropsychopharmacology 31: 1444-51 Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA (2001) J Neurosci 21: 7397-403 Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, Carlezon WA (2006) J Neurosci 26: 11665-9 Psychostimulant-induced Fos protein expression in the thalamic paraventricular nucleus. Deutch AY, Bubser M, Young CD (1998) J Neurosci 18: 10680-7 Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E, Neve RL, Nestler EJ, Carlezon WA (2009) J Neurosci 29: 1855-9 AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis. Reissner KJ, Uys JD, Schwacke JH, Comte-Walters S, Rutherford-Bethard JL, Dunn TE, Blumer JB, Schey KL, Kalivas PW (2011) J Neurosci 31: 5648-58 Mechanisms Associated With Physical Activity Behavior: Insights From Rodent Experiments. Roberts MD, Ruegsegger GN, Brown JD, Booth FW (2017) Exerc Sport Sci Rev 45: 217-222 Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Dong Y, Dani JA, Blakely RD (2013) Biochem Pharmacol 86: 1084-8 Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA (2009) Mol Pharmacol 75: 704-12 Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behaviour. Roberts MD, Toedebusch RG, Wells KD, Company JM, Brown JD, Cruthirds CL, Heese AJ, Zhu C, Rottinghaus GE, Childs TE, Booth FW (2014) J Physiol 592: 2119-35 Cocaine-induced locomotor activity in rats selectively bred for low and high voluntary running behavior. Brown JD, Green CL, Arthur IM, Booth FW, Miller DK (2015) Psychopharmacology (Berl) 232: 673-81 Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Salvatore MF, Garcia-Espana A, Goldstein M, Deutch AY, Haycock JW (2000) J Neurochem 75: 225-32 Mechanisms underlying methamphetamine-induced dopamine transporter complex formation. Hadlock GC, Baucum AJ, King JL, Horner KA, Cook GA, Gibb JW, Wilkins DG, Hanson GR, Fleckenstein AE (2009) J Pharmacol Exp Ther 329: 169-74 Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases. Wittmann M, Marino MJ, Henze DA, Seabrook GR, Conn PJ (2005) J Pharmacol Exp Ther 313: 594-603 Dopaminergic regulation of orexin neurons. Bubser M, Fadel JR, Jackson LL, Meador-Woodruff JH, Jing D, Deutch AY (2005) Eur J Neurosci 21: 2993-3001 Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex. Maple AM, Perna MK, Parlaman JP, Stanwood GD, Brown RW (2007) Eur J Neurosci 26: 2532-8 Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts. Stanwood GD, Parlaman JP, Levitt P (2006) Eur J Neurosci 24: 806-18 The distribution and origin of the calretinin-containing innervation of the nucleus accumbens of the rat. Bubser M, Scruggs JL, Young CD, Deutch AY (2000) Eur J Neurosci 12: 1591-8 The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. Brog JS, Salyapongse A, Deutch AY, Zahm DS (1993) J Comp Neurol 338: 255-78 Phenotypic and molecular differences between rats selectively bred to voluntarily run high vs. low nightly distances. Roberts MD, Brown JD, Company JM, Oberle LP, Heese AJ, Toedebusch RG, Wells KD, Cruthirds CL, Knouse JA, Ferreira JA, Childs TE, Brown M, Booth FW (2013) Am J Physiol Regul Integr Comp Physiol 304: R1024-35 Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats. Uys JD, Grey AC, Wiggins A, Schwacke JH, Schey KL, Kalivas PW (2010) J Mass Spectrom 45: 97-103 Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running. Ruegsegger GN, Brown JD, Kovarik MC, Miller DK, Booth FW (2016) Neuroscience 339: 525-537 Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Deutch AY, Cameron DS (1992) Neuroscience 46: 49-56 Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Rosin DL, Clark WA, Goldstein M, Roth RH, Deutch AY (1992) Neuroscience 48: 831-9 Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Deutch AY, Clark WA, Roth RH (1990) Brain Res 521: 311-5 Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Bubser M, Deutch AY (1998) Brain Res 787: 304-10 Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG (2008) Physiol Genomics 32: 283-98 Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance. Weiland BJ, Heitzeg MM, Zald D, Cummiford C, Love T, Zucker RA, Zubieta JK (2014) Psychiatry Res 223: 244-52 Apathy is associated with volume of the nucleus accumbens in patients infected with HIV. Paul RH, Brickman AM, Navia B, Hinkin C, Malloy PF, Jefferson AL, Cohen RA, Tate DF, Flanigan TP (2005) J Neuropsychiatry Clin Neurosci 17: 167-71 Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Bubser M, Deutch AY (1999) Synapse 32: 13-22 LTP in the mouse nucleus accumbens is developmentally regulated. Schramm NL, Egli RE, Winder DG (2002) Synapse 45: 213-9 A novel mouse brain slice preparation of the hippocampo-accumbens pathway. Matthews RT, Coker O, Winder DG (2004) J Neurosci Methods 137: 49-60
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