Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Podust LM, Poulos TL, Waterman MR (2001) Proc Natl Acad Sci U S A 98: 3068-73 Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. Pappas PG, Perfect JR, Cloud GA, Larsen RA, Pankey GA, Lancaster DJ, Henderson H, Kauffman CA, Haas DW, Saccente M, Hamill RJ, Holloway MS, Warren RM, Dismukes WE (2001) Clin Infect Dis 33: 690-9 Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14). Sohnle PG, Hunter MJ, Hahn B, Chazin WJ (2000) J Infect Dis 182: 1272-5 Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host. Bodily K, Perfect JR, Procop G, Washington MK, Affronti J (1996) Gastrointest Endosc 43: 518-21 Retroperitoneal fibrosis secondary to actinomycosis with no intrauterine device. Milam MR, Schultenover SJ, Crispens M, Parker L (2004) Obstet Gynecol 104: 1134-6 Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR (2010) J Biol Chem 285: 25582-90 Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI (2017) J Biol Chem 292: 6728-6743 Comparison of pharmacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised adolescents and healthy adults. Driscoll TA, Frangoul H, Nemecek ER, Murphey DK, Yu LC, Blumer J, Krance RA, Baruch A, Liu P (2011) Antimicrob Agents Chemother 55: 5780-9 Comparison of pharmacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised children and healthy adults. Driscoll TA, Yu LC, Frangoul H, Krance RA, Nemecek E, Blumer J, Arrieta A, Graham ML, Bradfield SM, Baruch A, Liu P (2011) Antimicrob Agents Chemother 55: 5770-9 Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology. Bellamine A, Lepesheva GI, Waterman MR (2004) J Lipid Res 45: 2000-7 Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI (2016) J Lipid Res 57: 1552-63 Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51). Lepesheva GI, Villalta F, Waterman MR (2011) Adv Parasitol 75: 65-87 Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. Qureshi A, Subathra M, Grey A, Schey K, Del Poeta M, Luberto C (2010) PLoS One 5: e15587 The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Yang S, Wei S, Pozzi A, Capdevila JH (2009) Arch Biochem Biophys 489: 82-91 Hepatic uptake of the novel antifungal agent caspofungin. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB (2005) Drug Metab Dispos 33: 676-82 Peripheral blood eosinophilia as a clue to the diagnosis of an occult Coccidioides infection. Simons CM, Stratton CW, Kim AS (2011) Hum Pathol 42: 449-53 Candida infection in very low birth-weight infants: outcome and nephrotoxicity of treatment with liposomal amphotericin B (AmBisome). Weitkamp JH, Poets CF, Sievers R, Musswessels E, Groneck P, Thomas P, Bartmann P (1998) Infection 26: 11-5 Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. Weitkamp JH, Ozdas A, LaFleur B, Potts AL (2008) J Perinatol 28: 405-11 Nikkomycin Z is an effective inhibitor of the chytrid fungus linked to global amphibian declines. Holden WM, Fites JS, Reinert LK, Rollins-Smith LA (2014) Fungal Biol 118: 48-60 Antimicrobial dosing in acute renal replacement. Fissell WH (2013) Adv Chronic Kidney Dis 20: 85-93 Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents. Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL (1999) Yeast 15: 755-63 Treatment of amphibians infected with chytrid fungus: learning from failed trials with itraconazole, antimicrobial peptides, bacteria, and heat therapy. Woodhams DC, Geiger CC, Reinert LK, Rollins-Smith LA, Lam B, Harris RN, Briggs CJ, Vredenburg VT, Voyles J (2012) Dis Aquat Organ 98: 11-25 Nondisseminated histoplasmosis of the trachea. Bhojwani N, Hartman JB, Taylor DC, Herbert M, Corriveau M (2016) Clin Respir J 10: 255-8 Ritual Samoan body tattooing and associated sporotrichosis. Choong KY, Roberts LJ (1996) Australas J Dermatol 37: 50-3
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.