PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR (2006) Cell Metab 4: 491-7 The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR (2002) Mol Cell Biol 22: 3864-74 Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC (2004) Mol Cell Biol 24: 1365-77 The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3. Sen A, Pruijssers AJ, Dermody TS, García-Sastre A, Greenberg HB (2011) J Virol 85: 3717-32 Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Lindquist ME, Mainou BA, Dermody TS, Crowe JE (2011) Virology 413: 103-10 PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. Iida K, Li Y, McGrath BC, Frank A, Cavener DR (2007) BMC Cell Biol 8: 38 Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro. Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR (2014) Eur J Pharmacol 724: 193-203
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