Rational use of analgesic and antiinflammatory drugs. Crofford LJ (2001) N Engl J Med 345: 1844-6 Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ, Burk RF (1992) J Clin Invest 90: 2502-7 Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ (2010) Proc Natl Acad Sci U S A 107: 2699-704 Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA (2002) Proc Natl Acad Sci U S A 99: 7130-5 Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies. Sherrod SD, McLean JA (2016) Clin Chem 62: 77-83 New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Aronoff DM, Oates JA, Boutaud O (2006) Clin Pharmacol Ther 79: 9-19 Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Study Group (2015) Crit Care Med 43: 534-41 Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ, Ware LB (2013) Crit Care Med 41: 784-90 Toward feedback-controlled anesthesia: voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions. Kivlehan F, Garay F, Guo J, Chaum E, Lindner E (2012) Anal Chem 84: 7670-6 Chronic pain-related changes in endogenous opioid analgesia: a case report. Bruehl S, Chung OY, Chont M (2010) Pain 148: 167-71 Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Boutaud O, Roberts LJ (2011) Free Radic Biol Med 51: 1062-7 Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. Dixon SC, Nagle CM, Wentzensen N, Trabert B, Beeghly-Fadiel A, Schildkraut JM, Moysich KB, deFazio A, Australian Ovarian Cancer Study Group, Risch HA, Rossing MA, Doherty JA, Wicklund KG, Goodman MT, Modugno F, Ness RB, Edwards RP, Jensen A, Kjær SK, Høgdall E, Berchuck A, Cramer DW, Terry KL, Poole EM, Bandera EV, Paddock LE, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Pearce CL, Wu AH, Pike MC, Webb PM (2017) Br J Cancer 116: 1223-1228 Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. Law BK, Waltner-Law ME, Entingh AJ, Chytil A, Aakre ME, Nørgaard P, Moses HL (2000) J Biol Chem 275: 38261-7 Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR (2003) J Biol Chem 278: 13480-6 Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. Du J, Luan J, Liu H, Daniel TO, Peiper S, Chen TS, Yu Y, Horton LW, Nanney LB, Strieter RM, Richmond A (2002) J Leukoc Biol 71: 141-53 Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog. Moore MC, Werner U, Smith MS, Farmer TD, Cherrington AD (2013) Am J Physiol Endocrinol Metab 305: E1473-82 PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. Clyman RI, Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, Heuchan AM, Carey WA, Derrick M, Fernandez E, Sankar M, Leone T, Perez J, Serize A, PDA-TOLERATE (PDA: TO LEave it alone or Respond And Treat Early) Trial Investigators (2019) J Pediatr 205: 41-48.e6 Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O (2016) Mitochondrion 28: 88-95 Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats. Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A (2019) Toxicol Appl Pharmacol 372: 19-32 Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice. Pumford NR, Halmes NC, Martin BM, Cook RJ, Wagner C, Hinson JA (1997) J Pharmacol Exp Ther 280: 501-5 Perioperative intravenous acetaminophen attenuates lipid peroxidation in adults undergoing cardiopulmonary bypass: a randomized clinical trial. Billings FT, Petracek MR, Roberts LJ, Pretorius M (2015) PLoS One 10: e0117625 Protein targets of reactive electrophiles in human liver microsomes. Shin NY, Liu Q, Stamer SL, Liebler DC (2007) Chem Res Toxicol 20: 859-67 Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA (2009) Org Biomol Chem 7: 5103-12 Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment. Lewis TR, Shelton EL, Van Driest SL, Kannankeril PJ, Reese J (2018) Semin Fetal Neonatal Med 23: 232-238 N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Bender RP, Lindsey RH, Burden DA, Osheroff N (2004) Biochemistry 43: 3731-9 Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial. Stein CM, Griffin MR, Taylor JA, Pichert JW, Brandt KD, Ray WA (2001) Med Care 39: 436-45 Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial. Ray WA, Stein CM, Byrd V, Shorr R, Pichert JW, Gideon P, Arnold K, Brandt KD, Pincus T, Griffin MR (2001) Med Care 39: 425-35 Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat. Pannala VR, Wall ML, Estes SK, Trenary I, O'Brien TP, Printz RL, Vinnakota KC, Reifman J, Shiota M, Young JD, Wallqvist A (2018) Sci Rep 8: 11678 Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. El-Khuffash A, Jain A, Corcoran D, Shah PS, Hooper CW, Brown N, Poole SD, Shelton EL, Milne GL, Reese J, McNamara PJ (2014) Pediatr Res 76: 238-44 Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation. Yin H, Vergeade A, Shi Q, Zackert WE, Gruenberg KC, Bokiej M, Amin T, Ying W, Masterson TS, Zinkel SS, Oates JA, Boutaud O, Roberts LJ (2012) Biochem Biophys Res Commun 423: 224-8 Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog. Johnson KM, Farmer T, Schurr K, Patrick Donahue E, Farmer B, Neal D, Cherrington AD (2011) Endocrine 39: 229-34 Pharmacological closure of the patent ductus arteriosus: when treatment still makes sense. Gillam-Krakauer M, Hagadorn JI, Reese J (2019) J Perinatol 39: 1439-1441 Parental knowledge of different acetaminophen concentrations for infants and children. Barrett TW, Norton VC (2000) Acad Emerg Med 7: 718-21 High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study. Lipworth L, Abdel-Kader K, Morse J, Stewart TG, Kabagambe EK, Parr SK, Birdwell KA, Matheny ME, Hung AM, Blot WJ, Ikizler TA, Siew ED (2016) BMC Nephrol 17: 189
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