Fluorescent probes of the apoptolidins and their utility in cellular localization studies. DeGuire SM, Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA (2015) Angew Chem Int Ed Engl 54: 961-4 Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO (2022) Nat Chem Biol 18: 360-367 S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Ghavami S, Eshragi M, Ande SR, Chazin WJ, Klonisch T, Halayko AJ, McNeill KD, Hashemi M, Kerkhoff C, Los M (2010) Cell Res 20: 314-31 Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza. Karlström A, Heston SM, Boyd KL, Tuomanen EI, McCullers JA (2011) J Infect Dis 204: 1358-66 Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. Chazal N, Singer G, Aiken C, Hammarskjöld ML, Rekosh D (2001) J Virol 75: 4014-8 Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. Willhite DC, Cover TL, Blanke SR (2003) J Biol Chem 278: 48204-9 The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM (2006) J Biol Chem 281: 26289-97 Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Li Y, Wandinger-Ness A, Goldenring JR, Cover TL (2004) Mol Biol Cell 15: 1946-59 Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D. Ghidu VP, Wang J, Wu B, Liu Q, Jacobs A, Marnett LJ, Sulikowski GA (2008) J Org Chem 73: 4949-55 Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin. Cover TL, Reddy LY, Blaser MJ (1993) Infect Immun 61: 1427-31 Concerted, highly asynchronous, enzyme-catalyzed [4 + 2] cycloaddition in the biosynthesis of spinosyn A; computational evidence. Hess BA, Smentek L (2012) Org Biomol Chem 10: 7503-9 Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation. Aschner JL, Foster SL, Kaplowitz M, Zhang Y, Zeng H, Fike CD (2007) Am J Physiol Lung Cell Mol Physiol 292: L1515-25 Phase II studies of bryostatin-1 in patients with advanced sarcoma and advanced head and neck cancer. Brockstein B, Samuels B, Humerickhouse R, Arietta R, Fishkin P, Wade J, Sosman J, Vokes EE (2001) Invest New Drugs 19: 249-54 Algal Toxin Goniodomin A Binds Potassium Ion Selectively to Yield a Conformationally Altered Complex with Potential Biological Consequences. Tainter CJ, Schley ND, Harris CM, Stec DF, Song AK, Balinski A, May JC, McLean JA, Reece KS, Harris TM (2020) J Nat Prod 83: 1069-1081 The toxin goniodomin, produced by Alexandrium spp., is identical to goniodomin A. Harris CM, Reece KS, Stec DF, Scott GP, Jones WM, Hobbs PLM, Harris TM (2020) Harmful Algae 92: 101707 Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR (2004) Protein Sci 13: 255-68 The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. Chong KM, Leelatian N, Deguire SM, Brockman AA, Earl D, Ihrie RA, Irish JM, Bachmann BO, Sulikowski GA (2016) J Antibiot (Tokyo) 69: 327-30
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