Keyword Connections

•  Alexander Gelbard
•  Ann Richmond
•  Damian Maseda

•  Daniel Moore
•  David Aronoff
•  Jacek Hawiger

•  Joern-Hendrik Weitkamp
•  Manuel Ascano
•  Mary Zutter

Resources

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Communities

• James (Tom) Thomas Laboratory

Publications

• Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
  Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C
  (2014) Nature 514: 372-375
• Immunology: TRIM5 does double duty.
  Aiken C, Joyce S
  (2011) Nature 472: 305-6
• Matrix metalloproteinases and the regulation of tissue remodelling.
  Page-McCaw A, Ewald AJ, Werb Z
  (2007) Nat Rev Mol Cell Biol 8: 221-33
• The roles of TGFβ in the tumour microenvironment.
  Pickup M, Novitskiy S, Moses HL
  (2013) Nat Rev Cancer 13: 788-99
• NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.
  van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T
  (2018) Cell 175: 1744-1755.e15
• Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
  Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW
  (2016) Cell 166: 1471-1484.e18
• Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.
  Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, Kwon YD, Pancera M, Taft J, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CC, Wu CY, Bewley CA, Burton DR, Koff WC, Connors M, Crispin M, Baxa U, Korber BT, Wong CH, Mascola JR, Kwong PD
  (2016) Cell 165: 813-26
• HIF-1alpha is essential for myeloid cell-mediated inflammation.
  Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS
  (2003) Cell 112: 645-57
• Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice.
  Lawrance SK, Karlsson L, Price J, Quaranta V, Ron Y, Sprent J, Peterson PA
  (1989) Cell 58: 583-94
• The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
  International HIV Controllers Study, Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao M
  (2010) Science 330: 1551-7
• Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
  Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC
  (1999) Science 286: 113-7
• Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
  Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K
  (2016) Science 351: 711-4
• Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.
  Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT
  (2014) Science 346: 861-5
• Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.
  Brown CB, Boyer AS, Runyan RB, Barnett JV
  (1999) Science 283: 2080-2
• Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
  Peek RM, Fiske C, Wilson KT
  (2010) Physiol Rev 90: 831-58
• Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine.
  Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W
  (1990) JAMA 263: 1641-5
• Natural killer cells determine the outcome of B cell-mediated autoimmunity.
  Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG
  (2000) Nat Immunol 1: 245-51
• Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.
  Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H
  (2011) Nat Immunol 12: 1086-95
• A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS.
  Boothby M, Lee K
  (2011) Nat Immunol 12: 811-2
• The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
  Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H
  (2009) Nat Immunol 10: 769-77
• Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
  Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R
  (2014) Cancer Cell 25: 719-34
• NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
  Beilke JN, Kuhl NR, Van Kaer L, Gill RG
  (2005) Nat Med 11: 1059-65
• Assessing the effect of pneumococcal conjugate vaccines: what is the value of routinely collected surveillance data?
  Grijalva CG, Moore MR, Griffin MR
  (2011) Lancet Infect Dis 11: 724-6
• The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
  Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD
  (2009) Immunity 30: 566-75
• CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.
  Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L
  (1997) Immunity 6: 469-77
• CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.
  Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D
  (2014) Immunity 41: 451-464
• Follicular B cell trafficking within the spleen actively restricts humoral immune responses.
  Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E
  (2010) Immunity 33: 254-65
• Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
  Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD
  (2016) Nat Neurosci 19: 243-52
• Cardio-Immuno-Oncology.
  Zaha VG, Meijers WC, Moslehi J
  (2020) Circulation 141: 87-89
• Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
  Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S
  (2011) Circulation 124: S3-9
• Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.
  Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L
  (2016) Nat Rev Clin Oncol 13: 674-690
• Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice.
  Clark JA, Flick RB, Pai LY, Szalayova I, Key S, Conley RK, Deutch AY, Hutson PH, Mezey E
  (2008) Mol Psychiatry 13: 498-506
• Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
  Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M
  (2017) Mol Psychiatry 22: 13-23
• Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.
  Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL
  (2008) Endocr Rev 29: 603-30
• The case for conducting a randomized clinical trial to assess the efficacy of a single dose of prophylactic HPV vaccines among adolescents.
  Kreimer AR, Sherman ME, Sahasrabuddhe VV, Safaeian M
  (2015) J Natl Cancer Inst 107:
• Repetitive weekly cycles of interleukin-2. II. Clinical and immunologic effects of dose, schedule, and addition of indomethacin.
  Sosman JA, Kohler PC, Hank JA, Moore KH, Bechhofer R, Storer B, Sondel PM
  (1988) J Natl Cancer Inst 80: 1451-61
• The role of toxins in Clostridium difficile infection.
  Chandrasekaran R, Lacy DB
  (2017) FEMS Microbiol Rev 41: 723-750
• Immune cell populations in cutaneous delayed-type hypersensitivity.
  Platt JL, Grant BW, Eddy AA, Michael AF
  (1983) J Exp Med 158: 1227-42