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Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition. Kaikita K, Fogo AB, Ma L, Schoenhard JA, Brown NJ, Vaughan DE (2001) Circulation 104: 839-44 CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG (2016) Circ Res 118: 1233-43 GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W (2010) Circ Res 106: 328-36 cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA (2005) Circ Res 96: 100-9 Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis. Smith LH, Dixon JD, Stringham JR, Eren M, Elokdah H, Crandall DL, Washington K, Vaughan DE (2006) Blood 107: 132-4 AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide. Shearer J, Fueger PT, Vorndick B, Bracy DP, Rottman JN, Clanton JA, Wasserman DH (2004) Diabetes 53: 1429-35 NO synthase inhibition increases aldosterone in humans. Muldowney JA, Davis SN, Vaughan DE, Brown NJ (2004) Hypertension 44: 739-45 Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition. Brown NJ, Muldowney JA, Vaughan DE (2006) Hypertension 47: 441-8 Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Widder JD, Guzik TJ, Mueller CF, Clempus RE, Schmidt HH, Dikalov SI, Griendling KK, Jones DP, Harrison DG (2007) Arterioscler Thromb Vasc Biol 27: 762-8 Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. Kaikita K, Schoenhard JA, Painter CA, Ripley RT, Brown NJ, Fogo AB, Vaughan DE (2002) J Mol Cell Cardiol 34: 617-27 Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes. Gunawardana SC, Head WS, Piston DW (2008) Am J Physiol Endocrinol Metab 294: E1097-108 Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Moore MC, Dicostanzo CA, Smith MS, Farmer B, Rodewald TD, Neal DW, Williams PE, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294: E768-77 Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice. Rottman JN, Bracy D, Malabanan C, Yue Z, Clanton J, Wasserman DH (2002) Am J Physiol Endocrinol Metab 283: E116-23 AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo. Shearer J, Fueger PT, Rottman JN, Bracy DP, Martin PH, Wasserman DH (2004) Am J Physiol Endocrinol Metab 287: E871-7 Insulin and heregulin-beta1 upregulate guanylyl cyclase C expression in rat hepatocytes: reversal by phosphodiesterase-3 inhibition. Scheving LA, Russell WE (2001) Cell Signal 13: 665-72 Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J (2014) Am J Physiol Heart Circ Physiol 307: H732-40 Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Dikalova AE, Góngora MC, Harrison DG, Lambeth JD, Dikalov S, Griendling KK (2010) Am J Physiol Heart Circ Physiol 299: H673-9 Heat shock protein 90-eNOS interactions mature with postnatal age in the pulmonary circulation of the piglet. Aschner JL, Zeng H, Kaplowitz MR, Zhang Y, Slaughter JC, Fike CD (2009) Am J Physiol Lung Cell Mol Physiol 296: L555-64 Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J (2004) Am J Physiol Regul Integr Comp Physiol 287: R652-60 Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wall. Reese J, O'Mara PW, Poole SD, Brown N, Tolentino C, Eckman DM, Aschner JL (2009) Prostaglandins Other Lipid Mediat 88: 89-96 Release of multiple endothelium-derived relaxing factors from porcine coronary arteries. Myers PR, Guerra R, Harrison DG (1992) J Cardiovasc Pharmacol 20: 392-400
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