Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. Okubo S, Niimura F, Nishimura H, Takemoto F, Fogo A, Matsusaka T, Ichikawa I (1997) J Clin Invest 99: 855-60 Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Brown NJ (2013) Nat Rev Nephrol 9: 459-69 Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ (2009) Kidney Int 75: 936-44 Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ (2012) Kidney Int 82: 643-51 Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ (2011) Diabetologia 54: 2152-63 Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown NJ (2009) Endocrinology 150: 2229-36 Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption. Martinerie L, Viengchareun S, Meduri G, Kim HS, Luther JM, Lombès M (2011) Endocrinology 152: 2483-91 Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone. Reddish MJ, Guengerich FP (2019) J Biol Chem 294: 12975-12991 Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. Zöllner A, Kagawa N, Waterman MR, Nonaka Y, Takio K, Shiro Y, Hannemann F, Bernhardt R (2008) FEBS J 275: 799-810 Aldosterone and inflammation. Gilbert KC, Brown NJ (2010) Curr Opin Endocrinol Diabetes Obes 17: 199-204
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