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Connections to Bone Morphogenetic Protein Receptors, Type II are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for Bone Morphogenetic Protein Receptors, Type II.
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- Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred.
Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE
(2001) N Engl J Med 345: 319-24 - Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance.
Cogan J, Austin E, Hedges L, Womack B, West J, Loyd J, Hamid R
(2012) Circulation 126: 1907-16 - Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.
Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED
(2016) Circulation 133: 82-97 - Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop.
Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB, National Heart, Lung and Blood Institute/Office of Rare Diseases
(2004) Circulation 109: 2947-52 - Genetics and genomics of pulmonary arterial hypertension.
Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M
(2013) J Am Coll Cardiol 62: D13-21 - Genetic basis of pulmonary arterial hypertension: current understanding and future directions.
Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G
(2004) J Am Coll Cardiol 43: 33S-39S - Genetics and genomics of pulmonary arterial hypertension.
Machado RD, Eickelberg O, Elliott CG, Geraci MW, Hanaoka M, Loyd JE, Newman JH, Phillips JA, Soubrier F, Trembath RC, Chung WK
(2009) J Am Coll Cardiol 54: S32-42 - Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies.
Newman JH, Phillips JA, Loyd JE
(2008) Ann Intern Med 148: 278-83 - Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM
(2017) J Clin Invest 127: 2262-2276 - The genetics of pulmonary arterial hypertension.
Austin ED, Loyd JE
(2014) Circ Res 115: 189-202 - Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension.
Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips JA
(2006) Am J Respir Crit Care Med 173: 798-802 - Somatic mutations in pulmonary arterial hypertension: primary or secondary events?
Austin ED, Hamid R, Ahmad F
(2010) Am J Respir Crit Care Med 182: 1094-6 - High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension.
Cogan JD, Pauciulo MW, Batchman AP, Prince MA, Robbins IM, Hedges LK, Stanton KC, Wheeler LA, Phillips JA, Loyd JE, Nichols WC
(2006) Am J Respir Crit Care Med 174: 590-8 - Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.
Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J
(2014) Am J Respir Crit Care Med 189: 325-34 - Precision Modeling of Pulmonary Hypertension Pathology with Induced Pluripotent Stem Cell-derived Cells.
West JD, Carrier EJ
(2018) Am J Respir Crit Care Med 198: 154-155 - Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD
(2010) Am J Respir Crit Care Med 182: 1153-60 - Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II.
Runo JR, Vnencak-Jones CL, Prince M, Loyd JE, Wheeler L, Robbins IM, Lane KB, Newman JH, Johnson J, Nichols WC, Phillips JA
(2003) Am J Respir Crit Care Med 167: 889-94 - Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.
Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR
(2016) Am J Respir Crit Care Med 194: 719-28 - Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension.
Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE
(2012) Am J Respir Crit Care Med 186: 892-6 - Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.
Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW
(2014) Am J Respir Crit Care Med 189: 1110-20 - Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.
Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL
(2012) Proc Natl Acad Sci U S A 109: 2814-9 - Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.
Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ
(2018) Nucleic Acids Res 46: 3458-3467 - BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation.
Pickup MW, Hover LD, Polikowsky ER, Chytil A, Gorska AE, Novitskiy SV, Moses HL, Owens P
(2015) Mol Oncol 9: 179-91 - Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension.
West J, Austin E, Fessel JP, Loyd J, Hamid R
(2014) Drug Discov Today 19: 1241-5 - Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J
(2017) Eur Respir J 50: - Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females.
Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE, Phillips JA
(2009) Eur Respir J 34: 1093-9 - A potential role for insulin resistance in experimental pulmonary hypertension.
West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR
(2013) Eur Respir J 41: 861-71 - Pre-implantation genetic testing for hereditary pulmonary arterial hypertension: promise and caution.
Hamid R, Loyd J
(2012) Eur Respir J 39: 1292-3 - XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues.
Frisch A, Wright CV
(1998) Development 125: 431-42 - Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension.
Brittain EL, Janz DR, Austin ED, Bastarache JA, Wheeler LA, Ware LB, Hemnes AR
(2014) Chest 146: 1478-1485 - Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension.
Phillips JA, Poling JS, Phillips CA, Stanton KC, Austin ED, Cogan JD, Wheeler L, Yu C, Newman JH, Dietz HC, Loyd JE
(2008) Genet Med 10: 359-65 - Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension.
Cogan JD, Vnencak-Jones CL, Phillips JA, Lane KB, Wheeler LA, Robbins IM, Garrison G, Hedges LK, Loyd JE
(2005) Genet Med 7: 169-74 - Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele.
Hamid R, Cogan JD, Hedges LK, Austin E, Phillips JA, Newman JH, Loyd JE
(2009) Hum Mutat 30: 649-54 - Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects.
Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E
(2015) Hum Mutat 36: 1113-27 - Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells.
Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD
(2008) J Biol Chem 283: 3877-88 - Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.
Prewitt AR, Ghose S, Frump AL, Datta A, Austin ED, Kenworthy AK, de Caestecker MP
(2015) J Biol Chem 290: 960-71 - Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.
Fessel JP, Flynn CR, Robinson LJ, Penner NL, Gladson S, Kang CJ, Wasserman DH, Hemnes AR, West JD
(2013) Am J Respir Cell Mol Biol 49: 778-87 - Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.
Flynn C, Zheng S, Yan L, Hedges L, Womack B, Fessel J, Cogan J, Austin E, Loyd J, West J, Zhao Z, Hamid R
(2012) Am J Respir Cell Mol Biol 47: 20-7 - Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension.
Hamid R, Hedges LK, Austin E, Phillips JA, Loyd JE, Cogan JD
(2010) Clin Genet 77: 280-6 - Hereditary spastic paraplegia-causing mutations in atlastin-1 interfere with BMPRII trafficking.
Zhao J, Hedera P
(2013) Mol Cell Neurosci 52: 87-96
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