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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Publications
- Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
(1995) Nature 378: 584-92 - Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP
(2012) Nature 482: 98-102 - NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW
(1998) Nature 392: 941-5 - ATR and ATRIP: partners in checkpoint signaling.
Cortez D, Guntuku S, Qin J, Elledge SJ
(2001) Science 294: 1713-6 - Allosteric activators of glucokinase: potential role in diabetes therapy.
Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
(2003) Science 301: 370-3 - Gene therapy insertional mutagenesis insights.
Davé UP, Jenkins NA, Copeland NG
(2004) Science 303: 333 - New driver mutations in non-small-cell lung cancer.
Pao W, Girard N
(2011) Lancet Oncol 12: 175-80 - Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.
McCaffrey LM, Montalbano J, Mihai C, Macara IG
(2012) Cancer Cell 22: 601-14 - Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.
Phillips N, Hayward RD, Koronakis V
(2004) Nat Cell Biol 6: 618-25 - ETAA1 acts at stalled replication forks to maintain genome integrity.
Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D
(2016) Nat Cell Biol 18: 1185-1195 - Axon growth-stimulus package includes local translation.
Macara IG, Iioka H, Mili S
(2009) Nat Cell Biol 11: 919-21 - The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.
Huo Y, Macara IG
(2014) Nat Cell Biol 16: 529-37 - Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.
Salic A, Lee E, Mayer L, Kirschner MW
(2000) Mol Cell 5: 523-32 - Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.
Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF
(2008) Cell Metab 8: 492-501 - Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER
(2012) J Am Coll Cardiol 60: 841-50 - Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
(2010) Nat Chem Biol 6: 829-36 - ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.
Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA, Tyska MJ
(2016) Dev Cell 36: 190-200 - The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.
Zhang H, Macara IG
(2008) Dev Cell 14: 216-26 - Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.
Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW
(2018) Dev Cell 44: 13-28.e3 - Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S
(2016) J Clin Invest 126: 1704-16 - p62 links β-adrenergic input to mitochondrial function and thermogenesis.
Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH
(2013) J Clin Invest 123: 469-78 - Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS
(2015) J Clin Invest 125: 1189-202 - The targeted podocyte.
Fogo AB
(2011) J Clin Invest 121: 2142-5 - Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, Engelman JA
(2008) J Clin Invest 118: 2609-19 - Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.
Bozym RA, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody TS, Sarkar SN, Coyne CB
(2012) Cell Host Microbe 11: 153-66 - The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.
McCaffrey LM, Macara IG
(2009) Genes Dev 23: 1450-60 - Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM
(1998) Genes Dev 12: 1415-24 - TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Mordes DA, Glick GG, Zhao R, Cortez D
(2008) Genes Dev 22: 1478-89 - Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.
Pfleger CM, Salic A, Lee E, Kirschner MW
(2001) Genes Dev 15: 1759-64 - Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK
(2013) Hepatology 58: 966-75 - Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T, Wada T, Nagao T, Kurose H
(2002) Circ Res 91: 961-9 - Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, Chen BH, Zhang B, Johnson AD, Ying S, Courchesne P, Raghavachari N, Wang R, Liu P, International Consortium for Blood Pressure GWAS (ICBP), O'Donnell CJ, Vasan R, Munson PJ, Madhur MS, Harrison DG, Yang X, Levy D
(2015) Mol Syst Biol 11: 799 - A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation.
Wang X, Page-McCaw A
(2014) J Cell Biol 206: 923-36 - Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon.
Lee E, Salic A, Kirschner MW
(2001) J Cell Biol 154: 983-93 - The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
(2021) Nat Commun 12: 5263 - The Par3 polarity protein is an exocyst receptor essential for mammary cell survival.
Ahmed SM, Macara IG
(2017) Nat Commun 8: 14867 - Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP
(2016) Nat Commun 7: 10318 - Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Zhou MM, Meadows RP, Logan TM, Yoon HS, Wade WS, Ravichandran KS, Burakoff SJ, Fesik SW
(1995) Proc Natl Acad Sci U S A 92: 7784-8 - Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.
Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ
(2006) Proc Natl Acad Sci U S A 103: 9536-41 - Dpb11 activates the Mec1-Ddc2 complex.
Mordes DA, Nam EA, Cortez D
(2008) Proc Natl Acad Sci U S A 105: 18730-4
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