A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Coffa G, Brash AR (2004) Proc Natl Acad Sci U S A 101: 15579-84 The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide. Oldham ML, Brash AR, Newcomer ME (2005) Proc Natl Acad Sci U S A 102: 297-302 On the relationship of coral allene oxide synthase to catalase. A single active site mutation that induces catalase activity in coral allene oxide synthase. Tosha T, Uchida T, Brash AR, Kitagawa T (2006) J Biol Chem 281: 12610-7 A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15. Valmsen K, Boeglin WE, Järving R, Järving I, Varvas K, Brash AR, Samel N (2007) J Biol Chem 282: 28157-63 Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality. Oldham ML, Brash AR, Newcomer ME (2005) J Biol Chem 280: 39545-52 8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases. Jin J, Boeglin WE, Cha JK, Brash AR (2012) J Lipid Res 53: 292-9 Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate. Jin J, Zheng Y, Brash AR (2013) Chem Res Toxicol 26: 896-903 The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME (2009) Biochemistry 48: 7906-15 Identification and characterization of an arachidonate 11R-lipoxygenase. Mortimer M, Järving R, Brash AR, Samel N, Järving I (2006) Arch Biochem Biophys 445: 147-55 Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations. Gao B, Boeglin WE, Brash AR (2008) Arch Biochem Biophys 477: 285-90 Coordination modes of tyrosinate-ligated catalase-type heme enzymes: magnetic circular dichroism studies of Plexaura homomalla allene oxide synthase, Mycobacterium avium ssp. paratuberculosis protein-2744c, and bovine liver catalase in their ferric and ferrous states. Bandara DM, Sono M, Bruce GS, Brash AR, Dawson JH (2011) J Inorg Biochem 105: 1786-94 Allene oxide synthases and allene oxides. Tijet N, Brash AR (2002) Prostaglandins Other Lipid Mediat 68-69: 423-31
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