Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC (2013) Cell 155: 844-57 Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP (2012) Cell 149: 49-62 Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Doughan AK, Harrison DG, Dikalov SI (2008) Circ Res 102: 488-96 Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis. Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS (2010) Free Radic Biol Med 49: 567-79 Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG (2014) J Biol Chem 289: 29614-30 The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. Panov A, Schonfeld P, Dikalov S, Hemendinger R, Bonkovsky HL, Brooks BR (2009) J Biol Chem 284: 14448-56 Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM (2006) Am J Physiol Endocrinol Metab 291: E525-35 Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O (2016) Mitochondrion 28: 88-95 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ (1999) J Neurochem 72: 1617-24 Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. Templeton N, Dean J, Reddy P, Young JD (2013) Biotechnol Bioeng 110: 2013-24 Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI (2013) Am J Physiol Heart Circ Physiol 305: H1131-40 Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. Sansome C, Zaika A, Marchenko ND, Moll UM (2001) FEBS Lett 488: 110-5 Rat diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles. Garcia-Cazarin ML, Gamboa JL, Andrade FH (2011) Am J Physiol Regul Integr Comp Physiol 300: R1311-5
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.