Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ (2009) J Clin Invest 119: 2577-89 Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, Bredt DS (2000) J Cell Biol 148: 159-72 The role of dynamic palmitoylation in Ca2+ channel inactivation. Hurley JH, Cahill AL, Currie KP, Fox AP (2000) Proc Natl Acad Sci U S A 97: 9293-8 Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA (1992) Proc Natl Acad Sci U S A 89: 10930-4 Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing. Sarett SM, Werfel TA, Chandra I, Jackson MA, Kavanaugh TE, Hattaway ME, Giorgio TD, Duvall CL (2016) Biomaterials 97: 122-32 P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF (2005) Neurobiol Dis 20: 969-85 Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Kanner SB, Reynolds AB, Parsons JT (1991) Mol Cell Biol 11: 713-20 Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ (2009) Psychoneuroendocrinology 34: 1257-62 Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. Camp LA, Hofmann SL (1993) J Biol Chem 268: 22566-74 Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. Lin DS, Connor WE, Wolf DP, Neuringer M, Hachey DL (1993) J Lipid Res 34: 491-9 Human lactation: maternal transfer of dietary triglycerides labeled with stable isotopes. Hachey DL, Thomas MR, Emken EA, Garza C, Brown-Booth L, Adlof RO, Klein PD (1987) J Lipid Res 28: 1185-92 Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD (2014) J Lipid Res 55: 1478-88 The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ (2005) J Lipid Res 46: 342-9 Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. Endocannabinoid Research Group, De Filippis D, D'Amico A, Cipriano M, Petrosino S, Orlando P, Di Marzo V, Iuvone T (2010) Pharmacol Res 61: 321-8 Hepatic TLR4 signaling in obese NAFLD. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR (2015) Am J Physiol Gastrointest Liver Physiol 309: G270-8 Fluorescence-based methods to image palmitoylated proteins. Kenworthy AK (2006) Methods 40: 198-205 Thiol-fatty acylation of the glucose transport protein of human erythrocytes. May JM (1990) FEBS Lett 274: 119-21 Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG (2014) Arch Biochem Biophys 546: 33-40 Uptake and utilization of metabolites in specific brain sites relative to feeding status. Kasser TR, Deutch A, Martin RJ (1986) Physiol Behav 36: 1161-5 Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles. Sarett SM, Kilchrist KV, Miteva M, Duvall CL (2015) J Biomed Mater Res A 103: 3107-16 Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB (2005) Biochem Biophys Res Commun 336: 309-15
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